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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SET

Summary for SET

Gene information	Gene symbol	SET
	Ensembl ID	ENSG00000119335
	Entrez ID	6418
	Gene name	SET nuclear proto-oncogene
	Synonyms	2PP2A\|IGAAD\|IPP2A2\|PHAPII\|TAF-I\|TAF-IBETA
	Gene type	protein_coding
	UniProtAcc	Q01105

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Dataset with differentially expressed gene: SET

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.838461	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.285741	9.22e-22
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.3028	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.586183	5.05e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.367123	4.80e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.33443	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.256465	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.421789	1.37e-17
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.403449	1.75e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.48155	2.16e-20
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.604351	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.263773	1.01e-40
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.435844	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.395175	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.308982	4.42e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.306982	9.24e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.28515	3.73e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.274146	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.362692	5.00e-25
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.255825	3.57e-18
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.497965	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.459153	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.377085	4.14e-37
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.608145	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.51033	0.00e+00

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Expression of SET in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SET

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SET

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SET	hsa-miR-1185-1-3p	99.2448	NM_001122821
SET	hsa-let-7f-2-3p	99.2448	NM_001122821
SET	hsa-miR-1185-2-3p	99.2448	NM_001122821
SET	hsa-miR-7151-5p	97.1516	NM_001122821
SET	hsa-miR-3613-3p	96.692	NM_001122821
SET	hsa-miR-589-5p	94.0676	NM_001122821
SET	hsa-miR-3123	93.8146	NM_001122821
SET	hsa-miR-6755-3p	93.5571	NM_001122821
SET	hsa-miR-6764-5p	92.2252	NM_001122821
SET	hsa-miR-4713-5p	92.1992	NM_001122821
SET	hsa-miR-1915-3p	91.808	NM_001122821
SET	hsa-miR-767-3p	91.7655	NM_001122821
SET	hsa-miR-6873-5p	90.2058	NM_001122821
SET	hsa-miR-4774-3p	90.1391	NM_001122821
SET	hsa-miR-3679-3p	90.1241	NM_001122821
SET	hsa-miR-6828-3p	89.7895	NM_001122821
SET	hsa-miR-1270	89.2707	NM_001122821
SET	hsa-miR-620	89.2707	NM_001122821
SET	hsa-miR-588	89.0959	NM_001122821
SET	hsa-miR-4701-5p	89.0959	NM_001122821
SET	hsa-miR-3171	88.8924	NM_001122821
SET	hsa-miR-548av-3p	88.5952	NM_001122821
SET	hsa-miR-769-5p	88.2121	NM_001122821
SET	hsa-miR-4516	87.7472	NM_001122821
SET	hsa-miR-548c-3p	87.508	NM_001122821
SET	hsa-miR-6071	87.4029	NM_001122821
SET	hsa-miR-10395-5p	86.1065	NM_001122821
SET	hsa-miR-4434	85.5026	NM_001122821
SET	hsa-miR-5703	85.5026	NM_001122821
SET	hsa-miR-548t-5p	85.3607	NM_001122821
SET	hsa-miR-548az-5p	85.3607	NM_001122821
SET	hsa-miR-3921	84.8358	NM_001122821
SET	hsa-miR-4653-5p	84.8358	NM_001122821
SET	hsa-miR-4310	84.5454	NM_001122821
SET	hsa-miR-629-3p	84.3316	NM_001122821
SET	hsa-miR-5195-3p	84.0503	NM_001122821
SET	hsa-miR-145-5p	84.0503	NM_001122821
SET	hsa-miR-3202	83.9804	NM_001122821
SET	hsa-miR-4668-5p	83.726	NM_001122821
SET	hsa-let-7a-3p	83.6909	NM_001122821
SET	hsa-miR-98-3p	83.6909	NM_001122821
SET	hsa-let-7b-3p	83.6909	NM_001122821
SET	hsa-let-7f-1-3p	83.6909	NM_001122821
SET	hsa-miR-766-5p	83.4724	NM_001122821
SET	hsa-miR-3177-5p	82.9729	NM_001122821
SET	hsa-miR-3663-3p	82.4417	NM_001122821
SET	hsa-miR-7153-3p	82.4165	NM_001122821
SET	hsa-miR-224-5p	82.1545	NM_001122821
SET	hsa-miR-4531	81.9622	NM_001122821
SET	hsa-miR-188-3p	81.2899	NM_001122821

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Motifs and transcription factors (TFs) regulating SET

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SET	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SET	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SET	metacluster_151.2	ZNF23 (directAnnotation).
SET	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SET	transfac_pro__M06071	ZNF814 (directAnnotation).
SET	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SET	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SET	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SET	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
SET	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SET	metacluster_126.14	ZBTB12; ZBTB12 (directAnnotation).
SET	transfac_pro__M05403	ADNP2 (inferredBy_Orthology).
SET	metacluster_161.18	DLX6 (directAnnotation).
SET	metacluster_161.21	GBX2 (directAnnotation).
SET	tfdimers__MD00350	CRX; POU2F1 (directAnnotation).
SET	metacluster_161.34	MNX1 (directAnnotation).
SET	metacluster_161.39	MSX1 (directAnnotation).
SET	transfac_pro__M04616	ISL1 (directAnnotation). LHX3 (inferredBy_Orthology).
SET	transfac_pro__M02869	HOXA3 (inferredBy_Orthology).
SET	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SET	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SET	metacluster_141.4	GLIS2 (directAnnotation).
SET	jaspar__MA0748.2	YY2 (directAnnotation).
SET	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SET	transfac_pro__M06259	ZNF91 (directAnnotation).
SET	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
SET	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
SET	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
SET	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
SET	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SET	transfac_pro__M04826	EP300 (directAnnotation).
SET	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SET	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SET	metacluster_191.5	SPDEF (inferredBy_Orthology).
SET	metacluster_141.2	E2F2; E2F3 (directAnnotation).
SET	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SET	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SET	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SET	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SET	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
SET	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
SET	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
SET	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
SET	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
SET	tfdimers__MD00475	FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; ZNF333 (directAnnotation).
SET	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
SET	metacluster_178.5	PAX3; ZNF337; ZNF337 (directAnnotation). PAX3 (inferredBy_Orthology).
SET	transfac_pro__M06237	ZNF846 (directAnnotation).
SET	transfac_pro__M01253	CNOT3 (directAnnotation).
SET	transfac_pro__M12697	ZNF142 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."