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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SESTD1

Summary for SESTD1

Gene information	Gene symbol	SESTD1
	Ensembl ID	ENSG00000187231
	Entrez ID	91404
	Gene name	SEC14 and spectrin domain containing 1
	Synonyms	DKFZp434O0515\|Solo
	Gene type	protein_coding
	UniProtAcc	Q86VW0

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Dataset with differentially expressed gene: SESTD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.406392	0.00e+00

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Expression of SESTD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SESTD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SESTD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SESTD1	hsa-miR-4282	99.3312	NM_178123
SESTD1	hsa-miR-29b-3p	99.3122	NM_178123
SESTD1	hsa-miR-29a-3p	99.3122	NM_178123
SESTD1	hsa-miR-29c-3p	99.3122	NM_178123
SESTD1	hsa-miR-532-5p	98.4286	NM_178123
SESTD1	hsa-miR-5682	98.3675	NM_178123
SESTD1	hsa-miR-5692a	98.3098	NM_178123
SESTD1	hsa-miR-95-5p	98.2876	NM_178123
SESTD1	hsa-miR-5680	96.9147	NM_178123
SESTD1	hsa-miR-606	96.8011	NM_178123
SESTD1	hsa-miR-548c-3p	96.7689	NM_178123
SESTD1	hsa-miR-3123	96.0029	NM_178123
SESTD1	hsa-miR-148a-5p	95.8279	NM_178123
SESTD1	hsa-miR-3156-5p	95.7653	NM_178123
SESTD1	hsa-miR-524-5p	95.526	NM_178123
SESTD1	hsa-miR-520d-5p	95.526	NM_178123
SESTD1	hsa-miR-3133	95.4392	NM_178123
SESTD1	hsa-miR-767-5p	95.0774	NM_178123
SESTD1	hsa-miR-4483	95.021	NM_178123
SESTD1	hsa-miR-4276	94.9725	NM_178123
SESTD1	hsa-miR-4477a	94.7238	NM_178123
SESTD1	hsa-miR-4773	94.5694	NM_178123
SESTD1	hsa-miR-374c-5p	94.369	NM_178123
SESTD1	hsa-miR-655-3p	94.369	NM_178123
SESTD1	hsa-miR-4496	94.0831	NM_178123
SESTD1	hsa-miR-148a-3p	94.0254	NM_178123
SESTD1	hsa-miR-148b-3p	94.0254	NM_178123
SESTD1	hsa-miR-152-3p	94.0254	NM_178123
SESTD1	hsa-miR-9983-3p	93.8077	NM_178123
SESTD1	hsa-miR-30a-3p	93.7488	NM_178123
SESTD1	hsa-miR-30d-3p	93.7488	NM_178123
SESTD1	hsa-miR-30e-3p	93.7488	NM_178123
SESTD1	hsa-miR-6740-3p	93.1444	NM_178123
SESTD1	hsa-miR-4633-5p	93.1154	NM_178123
SESTD1	hsa-miR-12124	92.8974	NM_178123
SESTD1	hsa-miR-4799-5p	92.8838	NM_178123
SESTD1	hsa-miR-6871-3p	92.7519	NM_178123
SESTD1	hsa-miR-4311	92.6967	NM_178123
SESTD1	hsa-miR-448	92.5935	NM_178123
SESTD1	hsa-miR-6885-3p	91.9061	NM_178123
SESTD1	hsa-miR-4714-5p	91.8367	NM_178123
SESTD1	hsa-miR-590-3p	91.6135	NM_178123
SESTD1	hsa-miR-5580-3p	91.3067	NM_178123
SESTD1	hsa-miR-938	91.1822	NM_178123
SESTD1	hsa-miR-9-3p	91.107	NM_178123
SESTD1	hsa-miR-129-5p	91.0522	NM_178123
SESTD1	hsa-miR-10525-3p	90.9912	NM_178123
SESTD1	hsa-miR-506-3p	90.8324	NM_178123
SESTD1	hsa-miR-124-3p	90.8324	NM_178123
SESTD1	hsa-miR-1293	90.6437	NM_178123

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Motifs and transcription factors (TFs) regulating SESTD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SESTD1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SESTD1	transfac_pro__M04950	EGR1 (directAnnotation).
SESTD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SESTD1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SESTD1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SESTD1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
SESTD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SESTD1	transfac_pro__M00652	NRF1 (directAnnotation).
SESTD1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SESTD1	transfac_pro__M04866	HDAC2 (directAnnotation).
SESTD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SESTD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SESTD1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."