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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SERTAD4

Summary for SERTAD4

Gene information	Gene symbol	SERTAD4
	Ensembl ID	ENSG00000281230
	Entrez ID	56256
	Gene name	SERTA domain containing 4
	Synonyms	DJ667H12.2
	Gene type	protein_coding
	UniProtAcc	Q9NUC0

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Dataset with differentially expressed gene: SERTAD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.315528	0.00e+00

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Expression of SERTAD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SERTAD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SERTAD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SERTAD4	hsa-miR-4470	97.8709	NM_019605
SERTAD4	hsa-miR-182-5p	96.1084	NM_019605
SERTAD4	hsa-miR-197-3p	95.3581	NM_019605
SERTAD4	hsa-miR-4775	94.2618	NM_019605
SERTAD4	hsa-miR-4673	91.5867	NM_019605
SERTAD4	hsa-miR-3183	90.9557	NM_019605
SERTAD4	hsa-miR-487a-5p	90.5378	NM_019605
SERTAD4	hsa-miR-487b-5p	90.5378	NM_019605
SERTAD4	hsa-miR-4503	90.449	NM_019605
SERTAD4	hsa-miR-1537-5p	90.4065	NM_019605
SERTAD4	hsa-miR-4723-3p	90.0812	NM_019605
SERTAD4	hsa-miR-6769b-3p	90.0812	NM_019605
SERTAD4	hsa-miR-4645-5p	88.986	NM_019605
SERTAD4	hsa-miR-5683	88.9182	NM_019605
SERTAD4	hsa-miR-339-5p	88.27	NM_019605
SERTAD4	hsa-miR-590-3p	87.1512	NM_019605
SERTAD4	hsa-miR-506-3p	87.1123	NM_019605
SERTAD4	hsa-miR-124-3p	87.1123	NM_019605
SERTAD4	hsa-miR-548o-3p	86.3557	NM_019605
SERTAD4	hsa-miR-1323	86.3557	NM_019605
SERTAD4	hsa-miR-9851-3p	85.9203	NM_019605
SERTAD4	hsa-miR-593-5p	85.9203	NM_019605
SERTAD4	hsa-miR-8063	84.8106	NM_019605
SERTAD4	hsa-miR-3613-5p	84.5099	NM_019605
SERTAD4	hsa-miR-3128	84.4603	NM_019605
SERTAD4	hsa-miR-6828-3p	84.0183	NM_019605
SERTAD4	hsa-miR-370-3p	83.6406	NM_019605
SERTAD4	hsa-miR-6131	83.4877	NM_019605
SERTAD4	hsa-miR-133a-5p	83.4877	NM_019605
SERTAD4	hsa-miR-138-5p	83.4877	NM_019605
SERTAD4	hsa-miR-6885-5p	83.071	NM_019605
SERTAD4	hsa-miR-328-5p	83.071	NM_019605
SERTAD4	hsa-miR-4714-5p	81.618	NM_019605
SERTAD4	hsa-miR-2355-3p	81.5498	NM_019605
SERTAD4	hsa-miR-1206	81.3836	NM_019605
SERTAD4	hsa-let-7c-3p	80.4276	NM_019605

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Motifs and transcription factors (TFs) regulating SERTAD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SERTAD4	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SERTAD4	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SERTAD4	transfac_pro__M04950	EGR1 (directAnnotation).
SERTAD4	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SERTAD4	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SERTAD4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SERTAD4	transfac_pro__M00652	NRF1 (directAnnotation).
SERTAD4	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SERTAD4	transfac_pro__M04866	HDAC2 (directAnnotation).
SERTAD4	jaspar__MA1122.1	TFDP1 (directAnnotation).
SERTAD4	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."