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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SERTAD2

Summary for SERTAD2

Gene information	Gene symbol	SERTAD2
	Ensembl ID	ENSG00000179833
	Entrez ID	9792
	Gene name	SERTA domain containing 2
	Synonyms	KIAA0127\|Sei-2\|TRIP-Br2
	Gene type	protein_coding
	UniProtAcc	Q14140

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Dataset with differentially expressed gene: SERTAD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.361516	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.505328	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.375641	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.320788	1.32e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.271574	1.02e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.294279	1.29e-41
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.491376	1.60e-06

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Expression of SERTAD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SERTAD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SERTAD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SERTAD2	hsa-miR-493-5p	99.8796	NM_014755
SERTAD2	hsa-miR-5582-3p	99.6383	NM_014755
SERTAD2	hsa-miR-548n	99.6168	NM_014755
SERTAD2	hsa-miR-3163	99.4072	NM_014755
SERTAD2	hsa-miR-4282	99.1942	NM_014755
SERTAD2	hsa-miR-5589-3p	98.9224	NM_014755
SERTAD2	hsa-miR-153-3p	98.9055	NM_014755
SERTAD2	hsa-miR-6867-5p	98.8968	NM_014755
SERTAD2	hsa-miR-5011-5p	98.8697	NM_014755
SERTAD2	hsa-miR-5692a	98.7521	NM_014755
SERTAD2	hsa-miR-190a-3p	98.7435	NM_014755
SERTAD2	hsa-miR-548av-5p	98.3486	NM_014755
SERTAD2	hsa-miR-548k	98.3486	NM_014755
SERTAD2	hsa-miR-8054	98.3486	NM_014755
SERTAD2	hsa-miR-6887-5p	98.0256	NM_014755
SERTAD2	hsa-miR-6795-5p	98.0256	NM_014755
SERTAD2	hsa-miR-4447	97.6347	NM_014755
SERTAD2	hsa-miR-548az-5p	97.239	NM_014755
SERTAD2	hsa-miR-548t-5p	97.239	NM_014755
SERTAD2	hsa-miR-767-5p	97.1642	NM_014755
SERTAD2	hsa-miR-4418	97.036	NM_014755
SERTAD2	hsa-miR-509-3-5p	97.036	NM_014755
SERTAD2	hsa-miR-509-5p	97.036	NM_014755
SERTAD2	hsa-miR-607	96.8192	NM_014755
SERTAD2	hsa-miR-548ar-3p	96.7107	NM_014755
SERTAD2	hsa-miR-7109-5p	96.709	NM_014755
SERTAD2	hsa-miR-4472	96.4952	NM_014755
SERTAD2	hsa-miR-511-5p	96.3707	NM_014755
SERTAD2	hsa-miR-568	96.3307	NM_014755
SERTAD2	hsa-miR-548f-3p	95.9785	NM_014755
SERTAD2	hsa-miR-548az-3p	95.9785	NM_014755
SERTAD2	hsa-miR-548a-3p	95.9785	NM_014755
SERTAD2	hsa-miR-548e-3p	95.9785	NM_014755
SERTAD2	hsa-miR-548bc	95.9785	NM_014755
SERTAD2	hsa-miR-106b-5p	95.7277	NM_014755
SERTAD2	hsa-miR-20a-5p	95.7277	NM_014755
SERTAD2	hsa-miR-93-5p	95.454	NM_014755
SERTAD2	hsa-miR-20b-5p	95.454	NM_014755
SERTAD2	hsa-miR-17-5p	95.454	NM_014755
SERTAD2	hsa-miR-519d-3p	95.454	NM_014755
SERTAD2	hsa-miR-106a-5p	95.454	NM_014755
SERTAD2	hsa-miR-1912-5p	94.8694	NM_014755
SERTAD2	hsa-miR-4262	94.8416	NM_014755
SERTAD2	hsa-miR-526b-3p	94.5503	NM_014755
SERTAD2	hsa-miR-6830-3p	94.4295	NM_014755
SERTAD2	hsa-miR-4468	94.2559	NM_014755
SERTAD2	hsa-miR-3680-3p	93.9663	NM_014755
SERTAD2	hsa-miR-506-3p	93.7931	NM_014755
SERTAD2	hsa-miR-124-3p	93.7931	NM_014755
SERTAD2	hsa-miR-6856-3p	93.7276	NM_014755

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Motifs and transcription factors (TFs) regulating SERTAD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SERTAD2	metacluster_7.13	ZFX (directAnnotation).
SERTAD2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SERTAD2	metacluster_151.2	ZNF23 (directAnnotation).
SERTAD2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SERTAD2	transfac_pro__M05479	ZNF580 (directAnnotation).
SERTAD2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SERTAD2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SERTAD2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SERTAD2	hdpi__ETV4	ETV4 (directAnnotation).
SERTAD2	transfac_pro__M05628	ZNF735 (directAnnotation).
SERTAD2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SERTAD2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SERTAD2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SERTAD2	jaspar__MA0079.5	SP1 (directAnnotation).
SERTAD2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SERTAD2	metacluster_135.11	NR2C2 (directAnnotation).
SERTAD2	tfdimers__MD00038	TFAP2C (directAnnotation).
SERTAD2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SERTAD2	cisbp__M00968	MTF2 (directAnnotation).
SERTAD2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SERTAD2	cisbp__M00341	PAX6 (directAnnotation).
SERTAD2	metacluster_198.3	ZFP64 (directAnnotation).
SERTAD2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SERTAD2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SERTAD2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SERTAD2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SERTAD2	cisbp__M00788	ZFY (inferredBy_Orthology).
SERTAD2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SERTAD2	metacluster_175.1	ZNF283 (directAnnotation).
SERTAD2	hdpi__ZNF304	ZNF304 (directAnnotation).
SERTAD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SERTAD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SERTAD2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SERTAD2	transfac_pro__M01199	TRIM28 (directAnnotation).
SERTAD2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SERTAD2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SERTAD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SERTAD2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SERTAD2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SERTAD2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SERTAD2	jaspar__MA0748.2	YY2 (directAnnotation).
SERTAD2	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
SERTAD2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SERTAD2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SERTAD2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SERTAD2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SERTAD2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SERTAD2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SERTAD2	jaspar__MA1721.1	ZNF93 (directAnnotation).
SERTAD2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."