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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SERPINE1

Summary for SERPINE1

Gene information	Gene symbol	SERPINE1
	Ensembl ID	ENSG00000106366
	Entrez ID	5054
	Gene name	serpin family E member 1
	Synonyms	PAI\|PAI1\|PLANH1
	Gene type	protein_coding
	UniProtAcc	P05121

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Dataset with differentially expressed gene: SERPINE1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.986382	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.319051	1.18e-04
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.681465	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.253826	1.41e-02
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.475542	4.26e-32
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.384637	6.88e-04

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Expression of SERPINE1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SERPINE1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SERPINE1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SERPINE1	hsa-miR-5011-5p	99.9651	NM_000602
SERPINE1	hsa-miR-190a-3p	99.7297	NM_000602
SERPINE1	hsa-miR-4646-3p	95.2983	NM_000602
SERPINE1	hsa-miR-1825	93.7247	NM_000602
SERPINE1	hsa-miR-337-3p	90.5948	NM_000602
SERPINE1	hsa-miR-1277-5p	90.4516	NM_000602
SERPINE1	hsa-miR-3925-3p	90.4014	NM_000602
SERPINE1	hsa-miR-19b-3p	90.1545	NM_000602
SERPINE1	hsa-miR-19a-3p	90.1545	NM_000602
SERPINE1	hsa-miR-6771-3p	89.9294	NM_000602
SERPINE1	hsa-miR-510-3p	89.6191	NM_000602
SERPINE1	hsa-miR-4433b-5p	88.0587	NM_000602
SERPINE1	hsa-miR-4795-3p	86.5775	NM_000602
SERPINE1	hsa-miR-2355-3p	85.7748	NM_000602
SERPINE1	hsa-miR-199a-5p	85.6203	NM_000602
SERPINE1	hsa-miR-199b-5p	85.6203	NM_000602
SERPINE1	hsa-miR-551b-5p	84.9636	NM_000602
SERPINE1	hsa-miR-486-5p	84.8752	NM_000602
SERPINE1	hsa-miR-494-3p	83.8342	NM_000602
SERPINE1	hsa-miR-642b-3p	82.053	NM_000602
SERPINE1	hsa-miR-642a-3p	82.053	NM_000602
SERPINE1	hsa-miR-4753-3p	80.538	NM_000602
SERPINE1	hsa-miR-3613-3p	80.0197	NM_000602

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Motifs and transcription factors (TFs) regulating SERPINE1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SERPINE1	transfac_pro__M07301	NFATC4 (directAnnotation).
SERPINE1	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
SERPINE1	transfac_pro__M05395	ZNF276 (inferredBy_Orthology).
SERPINE1	hdpi__RAB18	RAB18 (directAnnotation).
SERPINE1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SERPINE1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SERPINE1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SERPINE1	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
SERPINE1	transfac_pro__M05770	ZNF77 (directAnnotation).
SERPINE1	transfac_pro__M06602	ZNF669 (directAnnotation).
SERPINE1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
SERPINE1	metacluster_14.20	TFEB (directAnnotation).
SERPINE1	kznf__ZNF550_Imbeault2017_OM_RCADE	ZNF550 (directAnnotation).
SERPINE1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SERPINE1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SERPINE1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SERPINE1	"Alteplase"	DB00009	biotech
SERPINE1	"Anistreplase"	DB00029	biotech
SERPINE1	"Bucladesine"	DB13242	small molecule
SERPINE1	"Colforsin"	DB02587	small molecule
SERPINE1	"Copper"	DB09130	small molecule
SERPINE1	"Drotrecogin alfa"	DB00055	biotech
SERPINE1	"Fibrinolysin"	DB05254	biotech
SERPINE1	"Reteplase"	DB00015	biotech
SERPINE1	"Tenecteplase"	DB00031	biotech
SERPINE1	"Troglitazone"	DB00197	small molecule
SERPINE1	"Urokinase"	DB00013	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."