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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SERPINB8

Summary for SERPINB8

Gene information	Gene symbol	SERPINB8
	Ensembl ID	ENSG00000166401
	Entrez ID	5271
	Gene name	serpin family B member 8
	Synonyms	CAP2\|PI8
	Gene type	protein_coding
	UniProtAcc	P50452

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Dataset with differentially expressed gene: SERPINB8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.582428	0.00e+00

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Expression of SERPINB8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SERPINB8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SERPINB8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SERPINB8	hsa-miR-1910-5p	94.3237	NM_198833
SERPINB8	hsa-miR-542-3p	93.7235	NM_198833
SERPINB8	hsa-miR-12127	92.8937	NM_198833
SERPINB8	hsa-miR-513c-3p	91.8323	NM_198833
SERPINB8	hsa-miR-513a-3p	91.8323	NM_198833
SERPINB8	hsa-miR-5011-5p	91.3873	NM_198833
SERPINB8	hsa-miR-4481	91.3521	NM_001031848
SERPINB8	hsa-miR-6731-5p	91.2223	NM_001031848
SERPINB8	hsa-miR-8085	91.2223	NM_001031848
SERPINB8	hsa-miR-22-5p	91.1322	NM_198833
SERPINB8	hsa-miR-3606-3p	90.5163	NM_198833
SERPINB8	hsa-miR-4745-5p	90.2551	NM_001031848
SERPINB8	hsa-miR-5190	88.9899	NM_198833
SERPINB8	hsa-miR-452-3p	87.8948	NM_001031848
SERPINB8	hsa-miR-2053	87.654	NM_198833
SERPINB8	hsa-miR-1258	87.3566	NM_198833
SERPINB8	hsa-miR-616-5p	87.1479	NM_198833
SERPINB8	hsa-miR-371b-5p	87.1479	NM_198833
SERPINB8	hsa-miR-373-5p	87.1479	NM_198833
SERPINB8	hsa-miR-4803	85.5532	NM_198833
SERPINB8	hsa-miR-6823-5p	83.8973	NM_001031848
SERPINB8	hsa-miR-9898	82.9274	NM_198833
SERPINB8	hsa-miR-6831-5p	82.7101	NM_198833
SERPINB8	hsa-miR-4517	82.5545	NM_198833
SERPINB8	hsa-miR-3978	82.5247	NM_198833
SERPINB8	hsa-miR-520d-5p	81.5011	NM_198833
SERPINB8	hsa-miR-524-5p	81.5011	NM_198833
SERPINB8	hsa-miR-1910-3p	81.408	NM_198833
SERPINB8	hsa-miR-6511a-5p	81.408	NM_198833
SERPINB8	hsa-miR-1277-5p	81.3616	NM_198833
SERPINB8	hsa-miR-4789-3p	80.6486	NM_198833

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Motifs and transcription factors (TFs) regulating SERPINB8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SERPINB8	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SERPINB8	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SERPINB8	cisbp__M00968	MTF2 (directAnnotation).
SERPINB8	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SERPINB8	cisbp__M00341	PAX6 (directAnnotation).
SERPINB8	metacluster_198.3	ZFP64 (directAnnotation).
SERPINB8	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SERPINB8	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SERPINB8	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SERPINB8	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SERPINB8	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SERPINB8	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SERPINB8	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SERPINB8	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SERPINB8	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SERPINB8	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."