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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEPTIN6

Summary for SEPTIN6

Gene information	Gene symbol	SEPTIN6
	Ensembl ID	ENSG00000125354
	Entrez ID	23157
	Gene name	septin 6
	Synonyms	KIAA0128\|MGC16619\|MGC20339\|SEP2\|SEPT2\|SEPT6
	Gene type	protein_coding
	UniProtAcc	Q14141

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Dataset with differentially expressed gene: SEPTIN6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.349206	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.446886	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.256774	1.29e-19

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Expression of SEPTIN6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEPTIN6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEPTIN6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEPTIN6	hsa-miR-6867-5p	100	NM_015129
SEPTIN6	hsa-miR-3613-3p	99.1104	NM_015129
SEPTIN6	hsa-miR-4646-5p	95.1161	NM_015129
SEPTIN6	hsa-miR-204-3p	95.1161	NM_015129
SEPTIN6	hsa-miR-625-5p	94.5601	NM_145799
SEPTIN6	hsa-miR-223-3p	92.4715	NM_015129
SEPTIN6	hsa-miR-33a-3p	91.8148	NM_145802
SEPTIN6	hsa-miR-4447	90.2537	NM_145799
SEPTIN6	hsa-miR-6734-5p	90.0928	NM_145802
SEPTIN6	hsa-miR-7150	89.88	NM_145799
SEPTIN6	hsa-miR-4738-3p	89.5856	NM_015129
SEPTIN6	hsa-miR-4516	89.0008	NM_145802
SEPTIN6	hsa-miR-103a-3p	88.6938	NM_145799
SEPTIN6	hsa-miR-107	88.6938	NM_145799
SEPTIN6	hsa-miR-516b-3p	88.3228	NM_015129
SEPTIN6	hsa-miR-516a-3p	88.3228	NM_015129
SEPTIN6	hsa-miR-7162-5p	88.3228	NM_015129
SEPTIN6	hsa-miR-892c-5p	85.8502	NM_145802
SEPTIN6	hsa-miR-1245a	85.0458	NM_015129
SEPTIN6	hsa-miR-8079	85.0458	NM_015129
SEPTIN6	hsa-miR-520f-5p	84.2951	NM_015129
SEPTIN6	hsa-miR-5703	83.4376	NM_145802
SEPTIN6	hsa-miR-4434	83.4376	NM_145802
SEPTIN6	hsa-miR-4685-3p	82.9792	NM_145799
SEPTIN6	hsa-miR-4287	82.9792	NM_145799
SEPTIN6	hsa-miR-4472	82.4545	NM_145799
SEPTIN6	hsa-miR-670-5p	82.4474	NM_015129
SEPTIN6	hsa-miR-618	80.7653	NM_015129
SEPTIN6	hsa-miR-3978	80.7258	NM_145799
SEPTIN6	hsa-miR-1289	80.2121	NM_145799
SEPTIN6	hsa-miR-5585-5p	80.045	NM_015129

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Motifs and transcription factors (TFs) regulating SEPTIN6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."