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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEPHS1

Summary for SEPHS1

Gene information	Gene symbol	SEPHS1
	Ensembl ID	ENSG00000086475
	Entrez ID	22929
	Gene name	selenophosphate synthetase 1
	Synonyms	SPS\|SPS1
	Gene type	protein_coding
	UniProtAcc	P49903

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Dataset with differentially expressed gene: SEPHS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.277516	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.437659	6.75e-21
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.286636	0.00e+00

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Expression of SEPHS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEPHS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEPHS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEPHS1	hsa-miR-1283	99.0299	NM_001195602
SEPHS1	hsa-miR-6811-3p	98.2063	NM_001195602
SEPHS1	hsa-miR-498-3p	97.6377	NM_001195602
SEPHS1	hsa-miR-4709-5p	96.714	NM_001195604
SEPHS1	hsa-miR-6835-3p	96.5335	NM_001195602
SEPHS1	hsa-miR-335-5p	96.5125	NM_001195602
SEPHS1	hsa-miR-3616-5p	96.4242	NM_001195604
SEPHS1	hsa-miR-573	96.4242	NM_001195604
SEPHS1	hsa-miR-3646	96.398	NM_001195602
SEPHS1	hsa-miR-499b-5p	95.7314	NM_001195604
SEPHS1	hsa-miR-5581-3p	95.2694	NM_001195602
SEPHS1	hsa-miR-1290	94.3048	NM_001195602
SEPHS1	hsa-let-7b-3p	93.6942	NM_001195602
SEPHS1	hsa-let-7f-1-3p	93.6942	NM_001195602
SEPHS1	hsa-let-7a-3p	93.6942	NM_001195602
SEPHS1	hsa-miR-98-3p	93.6942	NM_001195602
SEPHS1	hsa-miR-3613-3p	92.5406	NM_001195602
SEPHS1	hsa-miR-219a-2-3p	92.0519	NM_001195604
SEPHS1	hsa-miR-194-5p	91.9926	NM_001195602
SEPHS1	hsa-miR-12132	91.821	NM_001195602
SEPHS1	hsa-miR-218-5p	91.8102	NM_001195602
SEPHS1	hsa-miR-337-3p	91.77	NM_001195604
SEPHS1	hsa-miR-6882-3p	91.0961	NM_001195602
SEPHS1	hsa-miR-8080	90.7523	NM_001195604
SEPHS1	hsa-miR-22-3p	90.7484	NM_001195602
SEPHS1	hsa-miR-8087	90.255	NM_001195604
SEPHS1	hsa-miR-8084	89.7579	NM_001195604
SEPHS1	hsa-miR-3662	89.4018	NM_001195602
SEPHS1	hsa-miR-1246	89.0578	NM_001195602
SEPHS1	hsa-miR-548an	88.9667	NM_001195604
SEPHS1	hsa-miR-4698	88.7397	NM_001195602
SEPHS1	hsa-miR-411-3p	88.1532	NM_001195602
SEPHS1	hsa-miR-379-3p	88.1532	NM_001195602
SEPHS1	hsa-miR-381-3p	87.4743	NM_001195602
SEPHS1	hsa-miR-300	87.4743	NM_001195602
SEPHS1	hsa-miR-876-5p	87.3862	NM_001195602
SEPHS1	hsa-miR-182-5p	86.637	NM_001195602
SEPHS1	hsa-miR-1261	86.3606	NM_001195604
SEPHS1	hsa-miR-657	85.6772	NM_001195604
SEPHS1	hsa-miR-1252-3p	85.594	NM_001195604
SEPHS1	hsa-miR-3163	84.0516	NM_001195604
SEPHS1	hsa-miR-496	83.9849	NM_001195604
SEPHS1	hsa-miR-3167	83.5186	NM_001195602
SEPHS1	hsa-miR-3121-3p	82.582	NM_001195602
SEPHS1	hsa-miR-29a-5p	82.31	NM_001195604
SEPHS1	hsa-miR-1914-5p	82.3049	NM_001195602
SEPHS1	hsa-miR-3121-5p	81.3623	NM_001195602
SEPHS1	hsa-miR-548c-3p	80.7059	NM_001195602

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Motifs and transcription factors (TFs) regulating SEPHS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEPHS1	hdpi__NFIX	NFIX (directAnnotation).
SEPHS1	transfac_pro__M03813	POU3F3 (directAnnotation).
SEPHS1	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
SEPHS1	hdpi__FOXM1	FOXM1 (directAnnotation).
SEPHS1	transfac_pro__M06074	ZNF732 (directAnnotation).
SEPHS1	transfac_pro__M05768	ZNF544 (directAnnotation).
SEPHS1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SEPHS1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SEPHS1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."