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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEMA4B

Summary for SEMA4B

Gene information	Gene symbol	SEMA4B
	Ensembl ID	ENSG00000185033
	Entrez ID	10509
	Gene name	semaphorin 4B
	Synonyms	KIAA1745\|MGC131831\|SEMAC\|SemC
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SEMA4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.1359	1.36e-16
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.271132	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.635761	6.86e-23
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.747699	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.784449	0.00e+00

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Expression of SEMA4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEMA4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEMA4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEMA4B	hsa-miR-4319	96.1245	NM_001324032
SEMA4B	hsa-miR-125a-5p	93.5162	NM_001324032
SEMA4B	hsa-miR-125b-5p	93.5162	NM_001324032
SEMA4B	hsa-miR-20a-5p	92.8222	NM_001324032
SEMA4B	hsa-miR-106b-5p	92.8222	NM_001324032
SEMA4B	hsa-miR-4477a	91.9246	NM_198925
SEMA4B	hsa-miR-526b-3p	91.239	NM_001324032
SEMA4B	hsa-miR-93-5p	91.239	NM_001324032
SEMA4B	hsa-miR-17-5p	91.239	NM_001324032
SEMA4B	hsa-miR-106a-5p	91.239	NM_001324032
SEMA4B	hsa-miR-519d-3p	91.239	NM_001324032
SEMA4B	hsa-miR-20b-5p	91.239	NM_001324032
SEMA4B	hsa-miR-548bb-3p	91.2116	NM_001324032
SEMA4B	hsa-miR-548z	91.2116	NM_001324032
SEMA4B	hsa-miR-548d-3p	91.2116	NM_001324032
SEMA4B	hsa-miR-548h-3p	91.2116	NM_001324032
SEMA4B	hsa-miR-548ac	91.2116	NM_001324032
SEMA4B	hsa-miR-24-3p	90.2568	NM_001324032
SEMA4B	hsa-miR-188-5p	88.5051	NM_198925
SEMA4B	hsa-miR-449b-5p	87.5031	NM_001324032
SEMA4B	hsa-miR-449a	87.5031	NM_001324032
SEMA4B	hsa-miR-34c-5p	87.5031	NM_001324032
SEMA4B	hsa-miR-34a-5p	87.5031	NM_001324032
SEMA4B	hsa-miR-345-5p	86.9491	NM_001324032
SEMA4B	hsa-miR-6721-5p	85.1459	NM_001324032
SEMA4B	hsa-miR-345-3p	83.7775	NM_001324032
SEMA4B	hsa-miR-497-3p	83.5956	NM_001324032
SEMA4B	hsa-miR-4710	82.6658	NM_198925
SEMA4B	hsa-miR-301b-5p	82.2315	NM_001324032
SEMA4B	hsa-miR-301a-5p	82.2315	NM_001324032
SEMA4B	hsa-miR-23a-3p	82.0186	NM_001324032
SEMA4B	hsa-miR-23b-3p	82.0186	NM_001324032
SEMA4B	hsa-miR-23c	82.0186	NM_001324032
SEMA4B	hsa-miR-6866-3p	81.8711	NM_198925
SEMA4B	hsa-miR-210-5p	81.4689	NM_198925
SEMA4B	hsa-miR-499b-5p	81.2382	NM_198925
SEMA4B	hsa-miR-4796-3p	80.7884	NM_001324032
SEMA4B	hsa-miR-4437	80.6038	NM_001324032
SEMA4B	hsa-miR-670-5p	80.0695	NM_001324032
SEMA4B	hsa-miR-6081	80.0268	NM_001324032

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Motifs and transcription factors (TFs) regulating SEMA4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEMA4B	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SEMA4B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SEMA4B	metacluster_198.3	ZFP64 (directAnnotation).
SEMA4B	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
SEMA4B	metacluster_22.29	NFE2 (directAnnotation).
SEMA4B	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SEMA4B	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."