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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEMA3C

Summary for SEMA3C

Gene information	Gene symbol	SEMA3C
	Ensembl ID	ENSG00000075223
	Entrez ID	10512
	Gene name	semaphorin 3C
	Synonyms	SEMAE\|SemE
	Gene type	protein_coding
	UniProtAcc	Q99985

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Dataset with differentially expressed gene: SEMA3C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.459365	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.359508	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.343518	7.84e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.320617	2.28e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.401508	2.22e-24
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.26465	7.44e-10
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.408668	7.53e-20
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.550439	0.00e+00

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Expression of SEMA3C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEMA3C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEMA3C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEMA3C	hsa-miR-154-3p	96.6109	NM_006379
SEMA3C	hsa-miR-487a-3p	96.6109	NM_006379
SEMA3C	hsa-miR-153-5p	95.7964	NM_006379
SEMA3C	hsa-miR-181b-2-3p	95.6162	NM_006379
SEMA3C	hsa-miR-181b-3p	95.6162	NM_006379
SEMA3C	hsa-miR-30a-3p	94.9316	NM_006379
SEMA3C	hsa-miR-30d-3p	94.9316	NM_006379
SEMA3C	hsa-miR-30e-3p	94.9316	NM_006379
SEMA3C	hsa-miR-3163	94.8184	NM_006379
SEMA3C	hsa-miR-4789-5p	94.6781	NM_006379
SEMA3C	hsa-miR-4420	94.0876	NM_006379
SEMA3C	hsa-miR-6079	94.0452	NM_006379
SEMA3C	hsa-miR-6828-5p	93.6332	NM_006379
SEMA3C	hsa-miR-3121-3p	93.4838	NM_006379
SEMA3C	hsa-miR-5692a	93.4089	NM_006379
SEMA3C	hsa-miR-4753-3p	93.0646	NM_006379
SEMA3C	hsa-miR-4672	92.2522	NM_006379
SEMA3C	hsa-miR-590-3p	92.0264	NM_006379
SEMA3C	hsa-let-7a-3p	91.3804	NM_006379
SEMA3C	hsa-miR-98-3p	91.3804	NM_006379
SEMA3C	hsa-let-7b-3p	91.3804	NM_006379
SEMA3C	hsa-let-7f-1-3p	91.3804	NM_006379
SEMA3C	hsa-miR-3140-3p	91.3734	NM_006379
SEMA3C	hsa-miR-1279	91.3303	NM_006379
SEMA3C	hsa-miR-3611	91.1641	NM_006379
SEMA3C	hsa-miR-627-5p	90.3943	NM_006379
SEMA3C	hsa-miR-501-3p	90.1799	NM_006379
SEMA3C	hsa-miR-502-3p	90.1799	NM_006379
SEMA3C	hsa-miR-5197-3p	89.6797	NM_006379
SEMA3C	hsa-miR-3667-5p	89.2629	NM_006379
SEMA3C	hsa-miR-6508-5p	89.2588	NM_006379
SEMA3C	hsa-miR-944	89.1887	NM_006379
SEMA3C	hsa-miR-651-3p	88.9411	NM_006379
SEMA3C	hsa-miR-1180-5p	88.687	NM_006379
SEMA3C	hsa-miR-7114-3p	88.687	NM_006379
SEMA3C	hsa-let-7f-2-3p	88.1768	NM_006379
SEMA3C	hsa-miR-1185-1-3p	88.1768	NM_006379
SEMA3C	hsa-miR-1185-2-3p	88.1768	NM_006379
SEMA3C	hsa-miR-4531	87.9403	NM_006379
SEMA3C	hsa-miR-4751	87.7368	NM_006379
SEMA3C	hsa-miR-3148	87.7112	NM_006379
SEMA3C	hsa-miR-4291	87.53	NM_006379
SEMA3C	hsa-miR-8067	87.4259	NM_006379
SEMA3C	hsa-miR-4282	87.4033	NM_006379
SEMA3C	hsa-miR-570-5p	87.3621	NM_006379
SEMA3C	hsa-miR-548ai	87.3621	NM_006379
SEMA3C	hsa-miR-548ag	87.3621	NM_006379
SEMA3C	hsa-miR-548ba	87.3621	NM_006379
SEMA3C	hsa-miR-6809-3p	86.4289	NM_006379
SEMA3C	hsa-miR-6835-3p	85.9537	NM_006379

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Motifs and transcription factors (TFs) regulating SEMA3C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEMA3C	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
SEMA3C	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
SEMA3C	transfac_pro__M06512	ZNF461 (directAnnotation).
SEMA3C	transfac_pro__M04844	MAX (directAnnotation).
SEMA3C	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
SEMA3C	hdpi__ETS1	ETS1 (directAnnotation).
SEMA3C	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SEMA3C	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SEMA3C	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SEMA3C	transfac_pro__M04950	EGR1 (directAnnotation).
SEMA3C	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SEMA3C	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SEMA3C	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SEMA3C	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SEMA3C	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
SEMA3C	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SEMA3C	transfac_pro__M00652	NRF1 (directAnnotation).
SEMA3C	hdpi__ETV4	ETV4 (directAnnotation).
SEMA3C	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SEMA3C	transfac_pro__M04866	HDAC2 (directAnnotation).
SEMA3C	jaspar__MA1122.1	TFDP1 (directAnnotation).
SEMA3C	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SEMA3C	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SEMA3C	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SEMA3C	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SEMA3C	metacluster_22.25	NFE2L2 (directAnnotation).
SEMA3C	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
SEMA3C	metacluster_22.17	NFE2 (directAnnotation).
SEMA3C	transfac_pro__M05770	ZNF77 (directAnnotation).
SEMA3C	metacluster_22.37	BACH1 (directAnnotation).
SEMA3C	metacluster_22.11	NFE2 (directAnnotation).
SEMA3C	metacluster_22.16	BACH2 (directAnnotation).
SEMA3C	metacluster_22.20	MAFG (directAnnotation).
SEMA3C	metacluster_22.34	BACH2 (directAnnotation).
SEMA3C	metacluster_22.1	MAFF (inferredBy_Orthology).
SEMA3C	metacluster_150.9	VSX2; VSX2 (directAnnotation).
SEMA3C	metacluster_22.33	MAFK (inferredBy_Orthology).
SEMA3C	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
SEMA3C	transfac_pro__M01253	CNOT3 (directAnnotation).
SEMA3C	transfac_pro__M04817	ZBTB33 (directAnnotation).
SEMA3C	cisbp__M07938	E2F1 (directAnnotation).
SEMA3C	hdpi__TP73	TP73 (directAnnotation).
SEMA3C	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SEMA3C	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
SEMA3C	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
SEMA3C	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
SEMA3C	cisbp__M02645	ETS1 (directAnnotation).
SEMA3C	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).
SEMA3C	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_1	ELK1; GCM1 (directAnnotation).
SEMA3C	transfac_pro__M05981	ZNF233 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."