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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEMA3A

Summary for SEMA3A

Gene information	Gene symbol	SEMA3A
	Ensembl ID	ENSG00000075213
	Entrez ID	10371
	Gene name	semaphorin 3A
	Synonyms	coll-1\|Hsema-I\|SEMA1\|SEMAD\|SemD
	Gene type	protein_coding
	UniProtAcc	Q14563

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Dataset with differentially expressed gene: SEMA3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.24183	5.35e-07

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Expression of SEMA3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEMA3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEMA3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEMA3A	hsa-miR-32-3p	99.3607	NM_006080
SEMA3A	hsa-miR-4496	99.1115	NM_006080
SEMA3A	hsa-miR-4261	99.0236	NM_006080
SEMA3A	hsa-miR-147b-5p	98.6229	NM_006080
SEMA3A	hsa-miR-12124	98.0956	NM_006080
SEMA3A	hsa-miR-4659b-5p	98.0288	NM_006080
SEMA3A	hsa-miR-4659a-5p	98.0288	NM_006080
SEMA3A	hsa-miR-5195-3p	96.7682	NM_006080
SEMA3A	hsa-miR-145-5p	96.7682	NM_006080
SEMA3A	hsa-miR-1260b	96.5666	NM_006080
SEMA3A	hsa-miR-1260a	96.5666	NM_006080
SEMA3A	hsa-miR-548p	96.2189	NM_006080
SEMA3A	hsa-miR-3671	95.777	NM_006080
SEMA3A	hsa-miR-335-3p	95.5216	NM_006080
SEMA3A	hsa-miR-4766-5p	95.0204	NM_006080
SEMA3A	hsa-miR-5692a	94.4468	NM_006080
SEMA3A	hsa-miR-199a-3p	93.9136	NM_006080
SEMA3A	hsa-miR-3129-5p	93.9136	NM_006080
SEMA3A	hsa-miR-199b-3p	93.9136	NM_006080
SEMA3A	hsa-miR-153-5p	93.7907	NM_006080
SEMA3A	hsa-miR-7110-3p	93.2235	NM_006080
SEMA3A	hsa-miR-3662	92.6843	NM_006080
SEMA3A	hsa-miR-4742-5p	92.6304	NM_006080
SEMA3A	hsa-miR-4728-3p	92.5438	NM_006080
SEMA3A	hsa-miR-448	92.4742	NM_006080
SEMA3A	hsa-miR-379-5p	92.431	NM_006080
SEMA3A	hsa-miR-106a-3p	92.4015	NM_006080
SEMA3A	hsa-miR-4482-3p	92.367	NM_006080
SEMA3A	hsa-miR-135b-5p	92.2645	NM_006080
SEMA3A	hsa-miR-135a-5p	92.2645	NM_006080
SEMA3A	hsa-miR-205-3p	92.1899	NM_006080
SEMA3A	hsa-miR-3529-5p	92.0417	NM_006080
SEMA3A	hsa-miR-6505-5p	92.0104	NM_006080
SEMA3A	hsa-miR-4774-3p	91.8553	NM_006080
SEMA3A	hsa-miR-510-3p	91.6166	NM_006080
SEMA3A	hsa-miR-4659b-3p	91.4385	NM_006080
SEMA3A	hsa-miR-4659a-3p	91.4385	NM_006080
SEMA3A	hsa-miR-217-5p	91.2805	NM_006080
SEMA3A	hsa-miR-539-5p	91.1321	NM_006080
SEMA3A	hsa-miR-365b-3p	90.727	NM_006080
SEMA3A	hsa-miR-365a-3p	90.727	NM_006080
SEMA3A	hsa-miR-22-5p	90.4516	NM_006080
SEMA3A	hsa-miR-16-5p	90.4515	NM_006080
SEMA3A	hsa-miR-195-5p	90.4515	NM_006080
SEMA3A	hsa-miR-15a-5p	90.4515	NM_006080
SEMA3A	hsa-miR-15b-5p	90.4515	NM_006080
SEMA3A	hsa-miR-6838-5p	90.4515	NM_006080
SEMA3A	hsa-miR-92b-3p	90.1775	NM_006080
SEMA3A	hsa-miR-92a-3p	90.1775	NM_006080
SEMA3A	hsa-miR-32-5p	90.1775	NM_006080

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Motifs and transcription factors (TFs) regulating SEMA3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEMA3A	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."