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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEL1L

Summary for SEL1L

Gene information	Gene symbol	SEL1L
	Ensembl ID	ENSG00000071537
	Entrez ID	6400
	Gene name	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
	Synonyms	Hrd3\|IBD2\|SEL1L1
	Gene type	protein_coding
	UniProtAcc	Q9UBV2

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Dataset with differentially expressed gene: SEL1L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.79578	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.289275	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.302637	8.02e-30
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.412824	1.26e-41

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Expression of SEL1L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEL1L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEL1L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEL1L	hsa-miR-5011-5p	99.718	NM_005065
SEL1L	hsa-miR-670-5p	98.6546	NM_005065
SEL1L	hsa-miR-1468-3p	98.4623	NM_001244984
SEL1L	hsa-miR-7853-5p	98.404	NM_005065
SEL1L	hsa-miR-105-5p	98.404	NM_005065
SEL1L	hsa-miR-6509-5p	96.7838	NM_005065
SEL1L	hsa-miR-513b-5p	96.7265	NM_005065
SEL1L	hsa-miR-3646	96.6935	NM_005065
SEL1L	hsa-miR-4254	96.6399	NM_005065
SEL1L	hsa-miR-4282	96.5089	NM_001244984
SEL1L	hsa-miR-190a-3p	96.4939	NM_005065
SEL1L	hsa-miR-4328	96.1396	NM_005065
SEL1L	hsa-miR-3180-5p	95.9909	NM_005065
SEL1L	hsa-miR-345-3p	95.7529	NM_005065
SEL1L	hsa-miR-4319	95.6763	NM_005065
SEL1L	hsa-miR-888-5p	95.5577	NM_005065
SEL1L	hsa-miR-380-5p	95.3019	NM_005065
SEL1L	hsa-miR-374a-5p	95.193	NM_005065
SEL1L	hsa-miR-204-3p	95.0561	NM_005065
SEL1L	hsa-miR-4646-5p	95.0282	NM_005065
SEL1L	hsa-miR-520e-5p	94.8732	NM_005065
SEL1L	hsa-miR-548an	94.8113	NM_005065
SEL1L	hsa-miR-4524a-3p	94.6812	NM_005065
SEL1L	hsa-miR-495-3p	94.6569	NM_005065
SEL1L	hsa-miR-101-3p	94.6213	NM_005065
SEL1L	hsa-miR-125a-5p	94.3045	NM_005065
SEL1L	hsa-miR-125b-5p	94.3045	NM_005065
SEL1L	hsa-miR-3662	93.8934	NM_005065
SEL1L	hsa-miR-5688	93.4455	NM_005065
SEL1L	hsa-miR-374b-5p	93.3566	NM_005065
SEL1L	hsa-miR-646	93.2611	NM_005065
SEL1L	hsa-miR-563	93.0044	NM_005065
SEL1L	hsa-miR-9902	92.8726	NM_005065
SEL1L	hsa-miR-4732-3p	92.6039	NM_005065
SEL1L	hsa-miR-543	92.5885	NM_005065
SEL1L	hsa-miR-6715a-3p	92.0331	NM_005065
SEL1L	hsa-miR-205-3p	91.8241	NM_005065
SEL1L	hsa-miR-1305	91.7628	NM_005065
SEL1L	hsa-miR-760	91.7329	NM_005065
SEL1L	hsa-miR-7-1-3p	91.7306	NM_005065
SEL1L	hsa-miR-7-2-3p	91.7306	NM_005065
SEL1L	hsa-miR-7154-5p	91.5266	NM_001244984
SEL1L	hsa-miR-4314	91.3686	NM_005065
SEL1L	hsa-miR-3680-3p	90.6797	NM_005065
SEL1L	hsa-miR-590-3p	90.6219	NM_001244984
SEL1L	hsa-miR-5582-3p	90.3634	NM_005065
SEL1L	hsa-miR-125b-2-3p	90.1439	NM_005065
SEL1L	hsa-miR-181b-3p	89.7251	NM_005065
SEL1L	hsa-miR-181b-2-3p	89.7251	NM_005065
SEL1L	hsa-miR-629-3p	89.566	NM_005065

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Motifs and transcription factors (TFs) regulating SEL1L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEL1L	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SEL1L	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SEL1L	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SEL1L	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
SEL1L	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SEL1L	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
SEL1L	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SEL1L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SEL1L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SEL1L	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SEL1L	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SEL1L	hdpi__ZNF304	ZNF304 (directAnnotation).
SEL1L	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SEL1L	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SEL1L	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SEL1L	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SEL1L	jaspar__MA0502.2	NFYB (directAnnotation).
SEL1L	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
SEL1L	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
SEL1L	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
SEL1L	transfac_pro__M06111	ZNF254 (directAnnotation).
SEL1L	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."