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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEC31A

Summary for SEC31A

Gene information	Gene symbol	SEC31A
	Ensembl ID	ENSG00000138674
	Entrez ID	22872
	Gene name	SEC31 homolog A, COPII coat complex component
	Synonyms	ABP125\|ABP130\|KIAA0905\|SEC31L1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SEC31A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.405265	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.261341	6.68e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.295848	1.39e-07
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.342113	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.318633	2.02e-14

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Expression of SEC31A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEC31A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEC31A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEC31A	hsa-miR-3941	98.5039	NM_001077206
SEC31A	hsa-miR-922	95.7866	NM_001077206
SEC31A	hsa-miR-6844	94.6982	NM_001077206
SEC31A	hsa-miR-4291	94.6224	NM_001077206
SEC31A	hsa-miR-12136	91.8249	NM_001077206
SEC31A	hsa-miR-3619-5p	90.8237	NM_001077206
SEC31A	hsa-miR-6835-3p	89.1204	NM_001077206
SEC31A	hsa-miR-8485	89.1086	NM_001077206
SEC31A	hsa-miR-603	88.1352	NM_001077206
SEC31A	hsa-miR-31-3p	87.5828	NM_001077206
SEC31A	hsa-miR-196a-3p	87.5001	NM_001077206
SEC31A	hsa-miR-1321	87.2936	NM_001077206
SEC31A	hsa-miR-4739	87.2936	NM_001077206
SEC31A	hsa-miR-4756-5p	87.2936	NM_001077206
SEC31A	hsa-miR-9-5p	86.9599	NM_001077206
SEC31A	hsa-miR-554	86.79	NM_001077206
SEC31A	hsa-miR-361-5p	86.5072	NM_001077206
SEC31A	hsa-miR-214-3p	86.4768	NM_001077206
SEC31A	hsa-miR-761	86.4768	NM_001077206
SEC31A	hsa-miR-4686	85.0358	NM_001077206
SEC31A	hsa-miR-6516-5p	84.5685	NM_001077206
SEC31A	hsa-miR-3148	83.5942	NM_001077206
SEC31A	hsa-miR-548as-3p	83.5761	NM_001077206
SEC31A	hsa-miR-4758-5p	83.2268	NM_001077206
SEC31A	hsa-miR-1238-5p	83.2268	NM_001077206
SEC31A	hsa-miR-5197-5p	80.3759	NM_001077206

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Motifs and transcription factors (TFs) regulating SEC31A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEC31A	transfac_pro__M07436	WT1 (directAnnotation).
SEC31A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SEC31A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SEC31A	transfac_pro__M02089	E2F3 (directAnnotation).
SEC31A	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SEC31A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SEC31A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SEC31A	transfac_pro__M08819	KLF2 (directAnnotation).
SEC31A	transfac_pro__M01303	SP1 (directAnnotation).
SEC31A	transfac_pro__M00716	ZBTB14 (directAnnotation).
SEC31A	transfac_pro__M07397	ZNF148 (directAnnotation).
SEC31A	metacluster_135.11	NR2C2 (directAnnotation).
SEC31A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SEC31A	tfdimers__MD00038	TFAP2C (directAnnotation).
SEC31A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SEC31A	metacluster_7.13	ZFX (directAnnotation).
SEC31A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SEC31A	cisbp__M00968	MTF2 (directAnnotation).
SEC31A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SEC31A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SEC31A	cisbp__M00341	PAX6 (directAnnotation).
SEC31A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SEC31A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SEC31A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SEC31A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SEC31A	cisbp__M00788	ZFY (inferredBy_Orthology).
SEC31A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SEC31A	metacluster_175.1	ZNF283 (directAnnotation).
SEC31A	hdpi__ZNF304	ZNF304 (directAnnotation).
SEC31A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SEC31A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SEC31A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SEC31A	transfac_pro__M01199	TRIM28 (directAnnotation).
SEC31A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SEC31A	metacluster_151.2	ZNF23 (directAnnotation).
SEC31A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SEC31A	transfac_pro__M03806	ZBTB7C (directAnnotation).
SEC31A	transfac_pro__M02898	SMAD3 (directAnnotation).
SEC31A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SEC31A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SEC31A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SEC31A	hdpi__HIP2	UBE2K (directAnnotation).
SEC31A	hdpi__NRL	NRL (directAnnotation).
SEC31A	transfac_pro__M00430	E2F1 (directAnnotation).
SEC31A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SEC31A	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SEC31A	transfac_pro__M07329	SP7 (directAnnotation).
SEC31A	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
SEC31A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SEC31A	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."