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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEC24D

Summary for SEC24D

Gene information	Gene symbol	SEC24D
	Ensembl ID	ENSG00000150961
	Entrez ID	9871
	Gene name	SEC24 homolog D, COPII coat complex component
	Synonyms	KIAA0755
	Gene type	protein_coding
	UniProtAcc	O94855

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Dataset with differentially expressed gene: SEC24D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.354417	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.44403	0.00e+00

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Expression of SEC24D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEC24D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEC24D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEC24D	hsa-miR-4328	96.354	NM_001318066
SEC24D	hsa-miR-211-5p	95.494	NM_001318066
SEC24D	hsa-miR-204-5p	95.494	NM_001318066
SEC24D	hsa-miR-4423-3p	95.4091	NM_001318066
SEC24D	hsa-miR-642b-5p	95.208	NM_014822
SEC24D	hsa-miR-875-3p	95.0162	NM_001318066
SEC24D	hsa-miR-6508-5p	94.0471	NM_001318066
SEC24D	hsa-miR-593-5p	93.9427	NM_001318066
SEC24D	hsa-miR-9851-3p	93.9427	NM_001318066
SEC24D	hsa-miR-8067	92.6472	NM_001318066
SEC24D	hsa-miR-6814-5p	91.8375	NM_001318066
SEC24D	hsa-let-7c-3p	91.5833	NM_001318066
SEC24D	hsa-miR-5011-5p	90.895	NM_001318066
SEC24D	hsa-miR-3663-3p	90.6307	NM_001318066
SEC24D	hsa-miR-4495	90.5376	NM_001318066
SEC24D	hsa-miR-5006-3p	89.9862	NM_001318066
SEC24D	hsa-miR-4755-5p	89.9862	NM_001318066
SEC24D	hsa-miR-4650-3p	89.952	NM_001318066
SEC24D	hsa-miR-944	89.5645	NM_001318066
SEC24D	hsa-miR-623	89.3373	NM_001318066
SEC24D	hsa-miR-5692a	89.0958	NM_001318066
SEC24D	hsa-miR-1284	88.9362	NM_001318066
SEC24D	hsa-miR-5579-5p	88.7974	NM_001318066
SEC24D	hsa-let-7d-3p	88.4248	NM_001318066
SEC24D	hsa-miR-605-5p	88.1951	NM_001318066
SEC24D	hsa-miR-6731-5p	87.1353	NM_001318066
SEC24D	hsa-miR-8085	87.1353	NM_001318066
SEC24D	hsa-miR-32-3p	86.5869	NM_001318066
SEC24D	hsa-miR-3686	86.0251	NM_001318066
SEC24D	hsa-miR-302c-5p	85.3731	NM_001318066
SEC24D	hsa-miR-124-5p	85.3186	NM_001318066
SEC24D	hsa-miR-5582-5p	85.268	NM_001318066
SEC24D	hsa-miR-493-5p	81.5468	NM_001318066
SEC24D	hsa-miR-29a-3p	81.2561	NM_001318066
SEC24D	hsa-miR-3622a-5p	81.2557	NM_001318066
SEC24D	hsa-miR-8062	81.0465	NM_001318066
SEC24D	hsa-miR-6831-5p	80.2705	NM_001318066
SEC24D	hsa-miR-152-5p	80.1783	NM_001318066

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Motifs and transcription factors (TFs) regulating SEC24D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEC24D	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SEC24D	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SEC24D	cisbp__M00968	MTF2 (directAnnotation).
SEC24D	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SEC24D	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SEC24D	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SEC24D	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SEC24D	metacluster_175.1	ZNF283 (directAnnotation).
SEC24D	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SEC24D	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SEC24D	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SEC24D	metacluster_151.2	ZNF23 (directAnnotation).
SEC24D	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."