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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEC14L1

Summary for SEC14L1

Gene information	Gene symbol	SEC14L1
	Ensembl ID	ENSG00000129657
	Entrez ID	6397
	Gene name	SEC14 like lipid binding 1
	Synonyms	PRELID4A\|SEC14L
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SEC14L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.409177	8.67e-27
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.349998	2.47e-07
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.52439	9.22e-26
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.439339	6.44e-12
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.269209	1.22e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.2916	6.88e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.3141	4.81e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.250103	3.17e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.341319	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.422582	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.317623	2.68e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.564706	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.351194	6.80e-24

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Expression of SEC14L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEC14L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEC14L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEC14L1	hsa-miR-3162-3p	99.9995	NM_003003
SEC14L1	hsa-miR-652-5p	99.9087	NM_003003
SEC14L1	hsa-miR-6761-5p	98.7071	NM_003003
SEC14L1	hsa-miR-129-2-3p	98.1849	NM_003003
SEC14L1	hsa-miR-129-1-3p	98.1849	NM_003003
SEC14L1	hsa-miR-4329	96.9721	NM_003003
SEC14L1	hsa-miR-6779-3p	96.5889	NM_003003
SEC14L1	hsa-miR-4687-5p	96.5889	NM_003003
SEC14L1	hsa-miR-4251	96.0158	NM_003003
SEC14L1	hsa-miR-6732-3p	95.8873	NM_003003
SEC14L1	hsa-miR-7161-5p	94.4189	NM_001039573
SEC14L1	hsa-miR-6876-5p	94.4039	NM_001039573
SEC14L1	hsa-miR-4476	94.4039	NM_001039573
SEC14L1	hsa-miR-889-5p	94.2535	NM_003003
SEC14L1	hsa-miR-641	94.0234	NM_003003
SEC14L1	hsa-miR-548u	93.9416	NM_001039573
SEC14L1	hsa-miR-499a-5p	93.6825	NM_003003
SEC14L1	hsa-miR-3680-3p	93.2372	NM_003003
SEC14L1	hsa-miR-3617-5p	92.3312	NM_003003
SEC14L1	hsa-miR-208a-3p	91.7684	NM_003003
SEC14L1	hsa-miR-208b-3p	91.7684	NM_003003
SEC14L1	hsa-miR-9986	91.3172	NM_001039573
SEC14L1	hsa-miR-1294	91.3172	NM_001039573
SEC14L1	hsa-miR-23c	91.2939	NM_003003
SEC14L1	hsa-miR-23b-3p	91.2939	NM_003003
SEC14L1	hsa-miR-23a-3p	91.2939	NM_003003
SEC14L1	hsa-miR-9983-3p	90.5291	NM_003003
SEC14L1	hsa-miR-190a-5p	90.1116	NM_003003
SEC14L1	hsa-miR-190b-5p	90.1116	NM_003003
SEC14L1	hsa-miR-4729	89.8582	NM_003003
SEC14L1	hsa-miR-6762-3p	89.1489	NM_003003
SEC14L1	hsa-miR-7-1-3p	88.7572	NM_001039573
SEC14L1	hsa-miR-7-2-3p	88.7572	NM_001039573
SEC14L1	hsa-miR-2113	88.4488	NM_003003
SEC14L1	hsa-miR-4424	88.434	NM_001144001
SEC14L1	hsa-miR-16-1-3p	88.2143	NM_001039573
SEC14L1	hsa-miR-135a-5p	87.8118	NM_003003
SEC14L1	hsa-miR-135b-5p	87.8118	NM_003003
SEC14L1	hsa-miR-129-5p	87.1348	NM_003003
SEC14L1	hsa-miR-520g-5p	86.7226	NM_003003
SEC14L1	hsa-miR-545-3p	82.5706	NM_003003
SEC14L1	hsa-miR-604	81.2877	NM_003003
SEC14L1	hsa-miR-612	81.164	NM_003003
SEC14L1	hsa-miR-3187-5p	81.164	NM_003003
SEC14L1	hsa-miR-6860	81.164	NM_003003
SEC14L1	hsa-miR-766-5p	80.9683	NM_001144001
SEC14L1	hsa-miR-95-5p	80.5689	NM_001039573
SEC14L1	hsa-miR-647	80.3803	NM_003003
SEC14L1	hsa-miR-5189-5p	80.2784	NM_003003
SEC14L1	hsa-miR-1285-3p	80.2784	NM_003003

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Motifs and transcription factors (TFs) regulating SEC14L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEC14L1	metacluster_7.13	ZFX (directAnnotation).
SEC14L1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SEC14L1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SEC14L1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SEC14L1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SEC14L1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SEC14L1	hdpi__ETV4	ETV4 (directAnnotation).
SEC14L1	transfac_pro__M05628	ZNF735 (directAnnotation).
SEC14L1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SEC14L1	jaspar__MA0079.5	SP1 (directAnnotation).
SEC14L1	transfac_pro__M04826	EP300 (directAnnotation).
SEC14L1	transfac_pro__M01299	MECP2 (directAnnotation).
SEC14L1	transfac_pro__M06213	ZNF267 (directAnnotation).
SEC14L1	transfac_pro__M01861	ATF1 (directAnnotation).
SEC14L1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SEC14L1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SEC14L1	metacluster_52.11	ZNF184 (directAnnotation).
SEC14L1	metacluster_98.1	ZNF524 (directAnnotation).
SEC14L1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SEC14L1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
SEC14L1	transfac_pro__M01783	SP2 (directAnnotation).
SEC14L1	transfac_pro__M01253	CNOT3 (directAnnotation).
SEC14L1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
SEC14L1	cisbp__M00968	MTF2 (directAnnotation).
SEC14L1	transfac_pro__M04817	ZBTB33 (directAnnotation).
SEC14L1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SEC14L1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SEC14L1	jaspar__MA0748.2	YY2 (directAnnotation).
SEC14L1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SEC14L1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SEC14L1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SEC14L1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
SEC14L1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SEC14L1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
SEC14L1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SEC14L1	transfac_pro__M04617	ZBTB7A (directAnnotation).
SEC14L1	transfac_pro__M01973	PLAG1 (directAnnotation).
SEC14L1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SEC14L1	tfdimers__MD00391	KLF4 (directAnnotation).
SEC14L1	tfdimers__MD00151	CHURC1 (directAnnotation).
SEC14L1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SEC14L1	transfac_public__M00491	PATZ1 (directAnnotation).
SEC14L1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SEC14L1	tfdimers__MD00038	TFAP2C (directAnnotation).
SEC14L1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
SEC14L1	metacluster_3.14	WT1; WT1 (directAnnotation).
SEC14L1	transfac_pro__M12697	ZNF142 (directAnnotation).
SEC14L1	transfac_pro__M01122	ZNF219 (directAnnotation).
SEC14L1	transfac_pro__M07387	ZBTB7A (directAnnotation).
SEC14L1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."