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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SDHD

Summary for SDHD

Gene information	Gene symbol	SDHD
	Ensembl ID	ENSG00000204370
	Entrez ID	6392
	Gene name	succinate dehydrogenase complex subunit D
	Synonyms	cybS\|PGL\|PGL1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SDHD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.534184	1.42e-07
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.993693	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.286094	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.296936	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.317254	9.55e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.434218	2.81e-28
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.281489	1.31e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.586896	0.00e+00

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Expression of SDHD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SDHD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SDHD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SDHD	hsa-miR-320b	98.1668	NM_001276506
SDHD	hsa-miR-320c	98.1668	NM_001276506
SDHD	hsa-miR-320d	98.1668	NM_001276506
SDHD	hsa-miR-320a-3p	98.1668	NM_001276506
SDHD	hsa-miR-4429	98.1668	NM_001276506
SDHD	hsa-miR-6875-3p	96.9693	NM_001276504
SDHD	hsa-miR-670-3p	96.7152	NM_001276504
SDHD	hsa-miR-5571-3p	94.0243	NM_001276504
SDHD	hsa-miR-924	93.9118	NM_001276504
SDHD	hsa-miR-2467-3p	92.7158	NM_001276506
SDHD	hsa-miR-410-3p	92.047	NM_001276504
SDHD	hsa-miR-4753-3p	91.2343	NM_001276506
SDHD	hsa-miR-4766-5p	90.316	NM_001276506
SDHD	hsa-miR-544a	90.2184	NM_001276506
SDHD	hsa-miR-23a-3p	87.8088	NM_001276504
SDHD	hsa-miR-23b-3p	87.8088	NM_001276504
SDHD	hsa-miR-23c	87.8088	NM_001276504
SDHD	hsa-miR-96-3p	86.9838	NM_001276504
SDHD	hsa-miR-3059-5p	86.9123	NM_001276504
SDHD	hsa-miR-7154-5p	85.117	NM_001276504
SDHD	hsa-miR-450a-1-3p	84.0802	NM_001276504
SDHD	hsa-miR-27b-5p	82.2526	NM_001276504
SDHD	hsa-miR-1238-3p	81.2821	NM_001276504
SDHD	hsa-miR-938	80.5613	NM_001276504
SDHD	hsa-miR-4755-5p	80.5347	NM_001276506
SDHD	hsa-miR-5006-3p	80.5347	NM_001276506

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Motifs and transcription factors (TFs) regulating SDHD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SDHD	hdpi__FLI1	FLI1 (directAnnotation).
SDHD	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SDHD	"2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol"	DB04141	small molecule
SDHD	"Hexachlorophene"	DB00756	small molecule
SDHD	"Ubiquinone Q1"	DB08689	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."