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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SDE2

Summary for SDE2

Gene information	Gene symbol	SDE2
	Ensembl ID	ENSG00000143751
	Entrez ID	163859
	Gene name	SDE2 telomere maintenance homolog
	Synonyms	C1orf55\|FLJ35382
	Gene type	protein_coding
	UniProtAcc	Q6IQ49

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Dataset with differentially expressed gene: SDE2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.276906	6.03e-05

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Expression of SDE2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SDE2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SDE2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SDE2	hsa-miR-616-5p	99.3753	NM_152608
SDE2	hsa-miR-373-5p	99.3753	NM_152608
SDE2	hsa-miR-371b-5p	99.3753	NM_152608
SDE2	hsa-miR-3163	99.3375	NM_152608
SDE2	hsa-miR-4499	93.5056	NM_152608
SDE2	hsa-miR-3658	92.6568	NM_152608
SDE2	hsa-miR-208b-5p	90.2879	NM_152608
SDE2	hsa-miR-208a-5p	90.2879	NM_152608
SDE2	hsa-miR-889-3p	90.068	NM_152608
SDE2	hsa-miR-1276	90.0498	NM_152608
SDE2	hsa-miR-6715a-3p	89.8831	NM_152608
SDE2	hsa-miR-379-5p	88.657	NM_152608
SDE2	hsa-miR-1283	88.2387	NM_152608
SDE2	hsa-miR-95-5p	87.9992	NM_152608
SDE2	hsa-miR-583	87.6266	NM_152608
SDE2	hsa-miR-4744	87.4367	NM_152608
SDE2	hsa-miR-3529-5p	87.2406	NM_152608
SDE2	hsa-miR-559	86.9192	NM_152608
SDE2	hsa-miR-3618	86.5994	NM_152608
SDE2	hsa-miR-548ae-5p	86.0902	NM_152608
SDE2	hsa-miR-548i	86.0902	NM_152608
SDE2	hsa-miR-548y	86.0902	NM_152608
SDE2	hsa-miR-548ab	86.0902	NM_152608
SDE2	hsa-miR-548aq-5p	86.0902	NM_152608
SDE2	hsa-miR-548a-5p	86.0902	NM_152608
SDE2	hsa-miR-548b-5p	86.0902	NM_152608
SDE2	hsa-miR-548ay-5p	86.0902	NM_152608
SDE2	hsa-miR-548j-5p	86.0902	NM_152608
SDE2	hsa-miR-548o-5p	86.0902	NM_152608
SDE2	hsa-miR-548d-5p	86.0902	NM_152608
SDE2	hsa-miR-548ad-5p	86.0902	NM_152608
SDE2	hsa-miR-548w	86.0902	NM_152608
SDE2	hsa-miR-548am-5p	86.0902	NM_152608
SDE2	hsa-miR-548c-5p	86.0902	NM_152608
SDE2	hsa-miR-548au-5p	86.0902	NM_152608
SDE2	hsa-miR-548ap-5p	86.0902	NM_152608
SDE2	hsa-miR-548ar-5p	86.0902	NM_152608
SDE2	hsa-miR-548h-5p	86.0902	NM_152608
SDE2	hsa-miR-548ak	86.0902	NM_152608
SDE2	hsa-miR-548bb-5p	86.0902	NM_152608
SDE2	hsa-miR-548as-5p	86.0902	NM_152608
SDE2	hsa-miR-6715b-3p	85.7389	NM_152608
SDE2	hsa-miR-4650-3p	85.66	NM_152608
SDE2	hsa-miR-545-5p	85.6378	NM_152608
SDE2	hsa-miR-3668	84.4443	NM_152608
SDE2	hsa-miR-651-3p	83.8477	NM_152608
SDE2	hsa-miR-548ar-3p	83.1317	NM_152608
SDE2	hsa-miR-6830-5p	82.9758	NM_152608
SDE2	hsa-miR-338-5p	82.2364	NM_152608
SDE2	hsa-miR-3613-3p	81.8884	NM_152608

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Motifs and transcription factors (TFs) regulating SDE2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SDE2	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
SDE2	transfac_pro__M01783	SP2 (directAnnotation).
SDE2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SDE2	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
SDE2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
SDE2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."