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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SCYL2

Summary for SCYL2

Gene information	Gene symbol	SCYL2
	Ensembl ID	ENSG00000136021
	Entrez ID	55681
	Gene name	SCY1 like pseudokinase 2
	Synonyms	CVAK104\|KIAA1360
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SCYL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.500083	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.35318	1.36e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.337652	1.63e-28

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Expression of SCYL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCYL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCYL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCYL2	hsa-miR-548ac	98.7539	NM_001317784
SCYL2	hsa-miR-548z	98.7539	NM_001317784
SCYL2	hsa-miR-548bb-3p	98.7539	NM_001317784
SCYL2	hsa-miR-548h-3p	98.7539	NM_001317784
SCYL2	hsa-miR-548d-3p	98.7539	NM_001317784
SCYL2	hsa-miR-335-3p	97.2553	NM_001317784
SCYL2	hsa-miR-548x-3p	97.0691	NM_001317784
SCYL2	hsa-miR-548aj-3p	97.0691	NM_001317784
SCYL2	hsa-miR-3662	96.3978	NM_001317784
SCYL2	hsa-miR-34a-3p	96.3325	NM_001317784
SCYL2	hsa-miR-520d-5p	95.3969	NM_001317784
SCYL2	hsa-miR-524-5p	95.3969	NM_001317784
SCYL2	hsa-miR-548ah-3p	95.3325	NM_001317784
SCYL2	hsa-miR-548j-3p	95.3325	NM_001317784
SCYL2	hsa-miR-548ae-3p	95.3325	NM_001317784
SCYL2	hsa-miR-548am-3p	95.3325	NM_001317784
SCYL2	hsa-miR-548aq-3p	95.3325	NM_001317784
SCYL2	hsa-miR-510-3p	95.2465	NM_001317784
SCYL2	hsa-miR-3646	94.2155	NM_001317784
SCYL2	hsa-miR-203a-3p	94.0038	NM_001317784
SCYL2	hsa-miR-1294	93.3855	NM_001317784
SCYL2	hsa-miR-9986	93.3855	NM_001317784
SCYL2	hsa-miR-561-3p	93.0112	NM_001317784
SCYL2	hsa-miR-4738-3p	92.6671	NM_001317784
SCYL2	hsa-miR-10523-5p	92.6182	NM_001317784
SCYL2	hsa-miR-1304-5p	91.7694	NM_001317784
SCYL2	hsa-miR-4325	90.4834	NM_001317784
SCYL2	hsa-miR-507	90.3628	NM_001317784
SCYL2	hsa-miR-4282	89.7794	NM_001317784
SCYL2	hsa-miR-452-3p	89.3336	NM_001317784
SCYL2	hsa-miR-6769b-3p	89.2288	NM_001317784
SCYL2	hsa-miR-4723-3p	89.2288	NM_001317784
SCYL2	hsa-miR-3183	89.2288	NM_001317784
SCYL2	hsa-miR-4426	88.8526	NM_001317784
SCYL2	hsa-miR-488-5p	88.0925	NM_001317784
SCYL2	hsa-miR-590-3p	87.8564	NM_001317784
SCYL2	hsa-miR-557	86.2297	NM_001317784
SCYL2	hsa-miR-5007-3p	86.1493	NM_001317784
SCYL2	hsa-miR-1827	85.5356	NM_001317784
SCYL2	hsa-miR-205-5p	85.139	NM_001317784
SCYL2	hsa-miR-766-5p	84.6931	NM_001317784
SCYL2	hsa-miR-4647	84.5103	NM_001317784
SCYL2	hsa-miR-4662b	84.5103	NM_001317784
SCYL2	hsa-miR-4799-5p	84.4875	NM_001317784
SCYL2	hsa-miR-10226	83.9634	NM_001317784
SCYL2	hsa-miR-12122	83.5048	NM_001317784
SCYL2	hsa-miR-10395-5p	82.9721	NM_001317784
SCYL2	hsa-miR-758-5p	82.0906	NM_001317784
SCYL2	hsa-miR-3912-3p	81.5786	NM_001317784
SCYL2	hsa-miR-545-3p	80.7627	NM_001317784

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Motifs and transcription factors (TFs) regulating SCYL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCYL2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SCYL2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
SCYL2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SCYL2	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SCYL2	metacluster_135.11	NR2C2 (directAnnotation).
SCYL2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SCYL2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SCYL2	metacluster_7.13	ZFX (directAnnotation).
SCYL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SCYL2	cisbp__M00968	MTF2 (directAnnotation).
SCYL2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SCYL2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SCYL2	cisbp__M00341	PAX6 (directAnnotation).
SCYL2	metacluster_198.3	ZFP64 (directAnnotation).
SCYL2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SCYL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SCYL2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SCYL2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SCYL2	cisbp__M00788	ZFY (inferredBy_Orthology).
SCYL2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SCYL2	metacluster_175.1	ZNF283 (directAnnotation).
SCYL2	hdpi__ZNF304	ZNF304 (directAnnotation).
SCYL2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SCYL2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SCYL2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SCYL2	transfac_pro__M01199	TRIM28 (directAnnotation).
SCYL2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SCYL2	metacluster_151.2	ZNF23 (directAnnotation).
SCYL2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SCYL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SCYL2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SCYL2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SCYL2	transfac_pro__M06441	ZSCAN30 (directAnnotation).
SCYL2	metacluster_114.2	OSR1; OSR2 (directAnnotation). OSR2 (inferredBy_Orthology).
SCYL2	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."