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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SCP2

Summary for SCP2

Gene information	Gene symbol	SCP2
	Ensembl ID	ENSG00000116171
	Entrez ID	6342
	Gene name	sterol carrier protein 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P22307

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Dataset with differentially expressed gene: SCP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.702122	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.257665	3.13e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.39159	1.27e-22
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.400781	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.374852	1.45e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.254032	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.30465	5.34e-16
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.275156	3.15e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.373289	1.08e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.394233	1.85e-34

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Expression of SCP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCP2	hsa-miR-3658	99.5502	NM_001193600
SCP2	hsa-miR-590-3p	98.7094	NM_001007250
SCP2	hsa-miR-4775	98.127	NM_001193600
SCP2	hsa-miR-4511	95.5405	NM_001193600
SCP2	hsa-miR-1304-3p	94.7394	NM_001193600
SCP2	hsa-miR-203a-3p	93.394	NM_001193600
SCP2	hsa-miR-1285-5p	93.2936	NM_001193600
SCP2	hsa-miR-10527-5p	93.2659	NM_001007250
SCP2	hsa-miR-3148	92.9552	NM_001007250
SCP2	hsa-miR-500a-5p	92.6092	NM_001193600
SCP2	hsa-miR-330-3p	92.5002	NM_001193600
SCP2	hsa-miR-4482-3p	92.0843	NM_001007250
SCP2	hsa-miR-3915	92.0425	NM_001007098
SCP2	hsa-miR-4760-5p	89.5118	NM_001193600
SCP2	hsa-miR-4704-3p	88.7421	NM_001007098
SCP2	hsa-miR-450a-1-3p	86.846	NM_001193600
SCP2	hsa-miR-3714	86.1442	NM_001007098
SCP2	hsa-miR-8061	85.1104	NM_001193600
SCP2	hsa-miR-1290	83.5325	NM_001007250
SCP2	hsa-miR-548p	82.6681	NM_001007250
SCP2	hsa-miR-1468-3p	81.8158	NM_001193600
SCP2	hsa-miR-922	81.4511	NM_001193600
SCP2	hsa-miR-6867-5p	80.9549	NM_001007098
SCP2	hsa-miR-4291	80.8793	NM_001193600

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Motifs and transcription factors (TFs) regulating SCP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCP2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SCP2	transfac_pro__M04950	EGR1 (directAnnotation).
SCP2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
SCP2	transfac_pro__M05981	ZNF233 (directAnnotation).
SCP2	transfac_pro__M05597	ZNF174 (directAnnotation).
SCP2	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
SCP2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
SCP2	transfac_pro__M06487	ZNF695 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."