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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SCNN1A

Summary for SCNN1A

Gene information	Gene symbol	SCNN1A
	Ensembl ID	ENSG00000111319
	Entrez ID	6337
	Gene name	sodium channel epithelial 1 subunit alpha
	Synonyms	ENaCalpha\|SCNN1
	Gene type	protein_coding
	UniProtAcc	P37088

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Dataset with differentially expressed gene: SCNN1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.638983	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.601095	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.820723	0.00e+00

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Expression of SCNN1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCNN1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCNN1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCNN1A	hsa-miR-4725-3p	97.2614	NM_001159575
SCNN1A	hsa-miR-6780b-5p	96.4721	NM_001159575
SCNN1A	hsa-miR-4271	95.7275	NM_001159575
SCNN1A	hsa-miR-6848-5p	95.59	NM_001038
SCNN1A	hsa-miR-6846-5p	95.59	NM_001038
SCNN1A	hsa-miR-6805-5p	92.814	NM_001038
SCNN1A	hsa-miR-6766-5p	91.2952	NM_001159575
SCNN1A	hsa-miR-6756-5p	91.2952	NM_001159575
SCNN1A	hsa-miR-6721-5p	90.6181	NM_001038
SCNN1A	hsa-miR-4530	88.5606	NM_001159575
SCNN1A	hsa-miR-664b-5p	86.7678	NM_001159575
SCNN1A	hsa-miR-450a-2-3p	83.0309	NM_001159575

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Motifs and transcription factors (TFs) regulating SCNN1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCNN1A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SCNN1A	transfac_pro__M06173	ZNF85 (directAnnotation).
SCNN1A	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SCNN1A	"Amiloride"	DB00594	small molecule
SCNN1A	"Triamterene"	DB00384	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."