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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SCN9A

Summary for SCN9A

Gene information	Gene symbol	SCN9A
	Ensembl ID	ENSG00000169432
	Entrez ID	6335
	Gene name	sodium voltage-gated channel alpha subunit 9
	Synonyms	ETHA\|Nav1.7\|NE-NA\|NENA\|PN1
	Gene type	protein_coding
	UniProtAcc	Q15858

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Dataset with differentially expressed gene: SCN9A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.795194	0.00e+00

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Expression of SCN9A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCN9A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCN9A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCN9A	hsa-miR-30e-5p	98.2716	NM_002977
SCN9A	hsa-miR-30d-5p	98.2716	NM_002977
SCN9A	hsa-miR-30a-5p	98.2716	NM_002977
SCN9A	hsa-miR-30c-5p	98.2716	NM_002977
SCN9A	hsa-miR-30b-5p	98.2716	NM_002977
SCN9A	hsa-miR-12136	98.1119	NM_002977
SCN9A	hsa-miR-3163	97.6419	NM_002977
SCN9A	hsa-miR-670-3p	97.3764	NM_002977
SCN9A	hsa-miR-186-5p	97.2295	NM_002977
SCN9A	hsa-miR-1277-5p	97.1808	NM_002977
SCN9A	hsa-miR-338-5p	96.1248	NM_002977
SCN9A	hsa-miR-548aw	95.6328	NM_002977
SCN9A	hsa-miR-606	95.233	NM_002977
SCN9A	hsa-miR-548ac	92.692	NM_002977
SCN9A	hsa-miR-29a-5p	92.4095	NM_002977
SCN9A	hsa-miR-217-5p	92.2473	NM_002977
SCN9A	hsa-miR-1537-5p	91.6035	NM_002977
SCN9A	hsa-miR-4282	91.3512	NM_002977
SCN9A	hsa-miR-1323	91.2635	NM_002977
SCN9A	hsa-miR-1468-3p	91.2575	NM_002977
SCN9A	hsa-miR-548aj-3p	91.1991	NM_002977
SCN9A	hsa-miR-548x-3p	91.1991	NM_002977
SCN9A	hsa-miR-6794-3p	91.1847	NM_002977
SCN9A	hsa-miR-586	91.0978	NM_002977
SCN9A	hsa-miR-371a-5p	90.8303	NM_002977
SCN9A	hsa-miR-7154-5p	90.6965	NM_002977
SCN9A	hsa-miR-3161	90.662	NM_002977
SCN9A	hsa-miR-548z	90.5981	NM_002977
SCN9A	hsa-miR-548bb-3p	90.5981	NM_002977
SCN9A	hsa-miR-548d-3p	90.5981	NM_002977
SCN9A	hsa-miR-548h-3p	90.5981	NM_002977
SCN9A	hsa-miR-607	90.5288	NM_002977
SCN9A	hsa-miR-5011-5p	90.478	NM_002977
SCN9A	hsa-miR-3149	89.9975	NM_002977
SCN9A	hsa-miR-548j-3p	89.7071	NM_002977
SCN9A	hsa-miR-548o-3p	89.5962	NM_002977
SCN9A	hsa-miR-548aq-3p	88.9623	NM_002977
SCN9A	hsa-miR-548am-3p	88.9623	NM_002977
SCN9A	hsa-miR-548ah-3p	88.9623	NM_002977
SCN9A	hsa-miR-548ae-3p	88.9623	NM_002977
SCN9A	hsa-miR-6807-3p	88.5726	NM_002977
SCN9A	hsa-miR-636	88.3595	NM_002977
SCN9A	hsa-miR-1179	88.27	NM_002977
SCN9A	hsa-miR-8055	87.8252	NM_002977
SCN9A	hsa-miR-4470	87.5019	NM_002977
SCN9A	hsa-miR-4495	87.2399	NM_002977
SCN9A	hsa-miR-6772-5p	87.2339	NM_002977
SCN9A	hsa-miR-577	87.2215	NM_002977
SCN9A	hsa-miR-1283	87.117	NM_002977
SCN9A	hsa-miR-190a-3p	87.0247	NM_002977

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Motifs and transcription factors (TFs) regulating SCN9A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCN9A	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
SCN9A	transfac_pro__M04950	EGR1 (directAnnotation).
SCN9A	metacluster_55.5	ZNF541 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SCN9A	"Lacosamide"	DB06218	small molecule
SCN9A	"Lidocaine"	DB00281	small molecule
SCN9A	"Rufinamide"	DB06201	small molecule
SCN9A	"Zonisamide"	DB00909	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."