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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SCIMP

Summary for SCIMP

Gene information	Gene symbol	SCIMP
	Ensembl ID	ENSG00000161929
	Entrez ID	388325
	Gene name	SLP adaptor and CSK interacting membrane protein
	Synonyms	C17orf87\|DTFT5783\|FLJ32580\|MGC163426\|MGC163428\|UNQ5783
	Gene type	protein_coding
	UniProtAcc	Q6UWF3

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Dataset with differentially expressed gene: SCIMP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE150930	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Mucosa-assisted lymphoid tissue (MALT) lymphoma	Immunotherapy	rituximab + cyclophosphamide + fludarabine	NA	Malignant cells	-0.259216	4.66e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.273422	2.40e-02

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Expression of SCIMP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCIMP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCIMP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCIMP	hsa-miR-4445-5p	90.9243	NM_207103
SCIMP	hsa-miR-371b-5p	88.8674	NM_001319190
SCIMP	hsa-miR-373-5p	88.8674	NM_001319190
SCIMP	hsa-miR-616-5p	88.8674	NM_001319190
SCIMP	hsa-miR-6827-5p	88.5829	NM_207103
SCIMP	hsa-miR-4684-5p	85.5496	NM_001319190
SCIMP	hsa-miR-6739-3p	84.2156	NM_207103
SCIMP	hsa-miR-6734-3p	83.607	NM_207103
SCIMP	hsa-miR-3613-3p	81.9977	NM_001319190
SCIMP	hsa-miR-625-5p	80.7907	NM_207103
SCIMP	hsa-miR-6842-3p	80.7418	NM_207103

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Motifs and transcription factors (TFs) regulating SCIMP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCIMP	swissregulon__hs__HBP1	HBP1 (directAnnotation).
SCIMP	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
SCIMP	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
SCIMP	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
SCIMP	taipale_tf_pairs__ERF_DLX2_RSCGGAANNNNNYMATTA_CAP_repr_1	DLX2; ERF (directAnnotation).
SCIMP	transfac_pro__M05613	ZNF35 (directAnnotation).
SCIMP	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
SCIMP	tfdimers__MD00208	IRF1; LTF (directAnnotation).
SCIMP	tfdimers__MD00056	EP300; ZEB1 (directAnnotation).
SCIMP	metacluster_12.1	ZNF3 (directAnnotation).
SCIMP	transfac_pro__M05858	ZNF625 (directAnnotation).
SCIMP	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
SCIMP	transfac_pro__M06398	ZNF761 (directAnnotation).
SCIMP	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
SCIMP	transfac_pro__M06013	ZFP69B (directAnnotation).
SCIMP	transfac_pro__M06153	ZNF83 (directAnnotation).
SCIMP	taipale_tf_pairs__GCM2_SOX15_RTRCGGGNNNNRNACAAWN_CAP	GCM2; SOX15 (directAnnotation).
SCIMP	taipale_tf_pairs__TEAD4_SPDEF_RGWATSCGGATGNNNNTCCKNNN_CAP_repr	SPDEF; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."