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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SCG2

Summary for SCG2

Gene information	Gene symbol	SCG2
	Ensembl ID	ENSG00000171951
	Entrez ID	7857
	Gene name	secretogranin II
	Synonyms	CHGC\|SgII\|SN
	Gene type	protein_coding
	UniProtAcc	P13521

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Dataset with differentially expressed gene: SCG2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.306864	0.00e+00

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Expression of SCG2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCG2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCG2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCG2	hsa-miR-3143	97.5504	NM_003469
SCG2	hsa-miR-543	95.8565	NM_003469
SCG2	hsa-miR-8485	93.9548	NM_003469
SCG2	hsa-miR-10399-5p	93.589	NM_003469
SCG2	hsa-miR-6504-3p	93.589	NM_003469
SCG2	hsa-miR-548x-3p	93.0496	NM_003469
SCG2	hsa-miR-548aj-3p	93.0496	NM_003469
SCG2	hsa-miR-4801	92.8449	NM_003469
SCG2	hsa-miR-4645-3p	92.5849	NM_003469
SCG2	hsa-miR-5692a	92.2046	NM_003469
SCG2	hsa-miR-548aq-3p	91.4205	NM_003469
SCG2	hsa-miR-548ae-3p	91.4205	NM_003469
SCG2	hsa-miR-548j-3p	91.4205	NM_003469
SCG2	hsa-miR-548ah-3p	91.4205	NM_003469
SCG2	hsa-miR-548am-3p	91.4205	NM_003469
SCG2	hsa-miR-1197	91.2839	NM_003469
SCG2	hsa-miR-1245b-5p	91.0589	NM_003469
SCG2	hsa-miR-3142	91.0589	NM_003469
SCG2	hsa-miR-5582-3p	90.8757	NM_003469
SCG2	hsa-miR-4731-3p	90.4823	NM_003469
SCG2	hsa-miR-95-5p	90.1232	NM_003469
SCG2	hsa-miR-7106-5p	87.7639	NM_003469
SCG2	hsa-miR-6847-5p	87.1728	NM_003469
SCG2	hsa-miR-5688	86.6212	NM_003469
SCG2	hsa-miR-155-5p	86.2157	NM_003469
SCG2	hsa-miR-198	86.0383	NM_003469
SCG2	hsa-miR-7-2-3p	85.3661	NM_003469
SCG2	hsa-miR-7-1-3p	85.3661	NM_003469
SCG2	hsa-miR-495-3p	85.3661	NM_003469
SCG2	hsa-miR-4425	84.2429	NM_003469
SCG2	hsa-miR-4635	83.5254	NM_003469
SCG2	hsa-miR-548d-3p	82.7181	NM_003469
SCG2	hsa-miR-548h-3p	82.7181	NM_003469
SCG2	hsa-miR-548z	82.7181	NM_003469
SCG2	hsa-miR-548bb-3p	82.7181	NM_003469
SCG2	hsa-miR-548ac	82.7181	NM_003469
SCG2	hsa-miR-9902	82.6176	NM_003469
SCG2	hsa-miR-1324	80.7259	NM_003469

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Motifs and transcription factors (TFs) regulating SCG2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCG2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."