Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SC5D

Summary for SC5D

Gene information	Gene symbol	SC5D
	Ensembl ID	ENSG00000109929
	Entrez ID	6309
	Gene name	sterol-C5-desaturase
	Synonyms	SC5DL
	Gene type	protein_coding
	UniProtAcc	O75845

Top

Dataset with differentially expressed gene: SC5D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.13811	1.49e-27
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.331931	0.00e+00

Top

Expression of SC5D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SC5D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SC5D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SC5D	hsa-miR-5692a	99.0965	NM_006918
SC5D	hsa-miR-545-5p	96.0987	NM_006918
SC5D	hsa-miR-12123	94.9669	NM_001024956
SC5D	hsa-miR-943	92.0084	NM_006918
SC5D	hsa-miR-548n	89.4595	NM_001024956
SC5D	hsa-miR-522-3p	89.3693	NM_006918
SC5D	hsa-miR-4481	88.9464	NM_006918
SC5D	hsa-miR-224-3p	88.7517	NM_006918
SC5D	hsa-miR-4745-5p	87.2278	NM_006918
SC5D	hsa-miR-4659b-3p	86.9193	NM_001024956
SC5D	hsa-miR-4659a-3p	86.9193	NM_001024956
SC5D	hsa-miR-4477a	86.7093	NM_006918
SC5D	hsa-miR-5011-5p	86.5988	NM_006918
SC5D	hsa-miR-942-5p	86.5682	NM_006918
SC5D	hsa-miR-4424	86.4748	NM_006918
SC5D	hsa-miR-520d-5p	86.0037	NM_001024956
SC5D	hsa-miR-524-5p	86.0037	NM_001024956
SC5D	hsa-miR-190a-3p	85.9286	NM_006918
SC5D	hsa-miR-570-3p	85.7076	NM_006918
SC5D	hsa-miR-3658	84.7294	NM_006918
SC5D	hsa-miR-3646	84.6479	NM_006918
SC5D	hsa-miR-3125	84.2702	NM_006918
SC5D	hsa-miR-4503	83.6069	NM_006918
SC5D	hsa-miR-29a-5p	83.3195	NM_006918
SC5D	hsa-miR-4680-5p	83.0114	NM_006918
SC5D	hsa-miR-6859-5p	82.7526	NM_006918
SC5D	hsa-miR-3187-5p	82.4989	NM_006918
SC5D	hsa-miR-143-3p	82.4545	NM_006918
SC5D	hsa-miR-4770	82.4545	NM_006918
SC5D	hsa-miR-4799-3p	81.7701	NM_006918
SC5D	hsa-miR-5588-5p	81.7701	NM_006918
SC5D	hsa-miR-4720-5p	81.7701	NM_006918
SC5D	hsa-miR-7159-5p	81.597	NM_006918
SC5D	hsa-miR-6077	81.3479	NM_006918
SC5D	hsa-miR-6088	80.9708	NM_006918
SC5D	hsa-miR-4766-3p	80.7331	NM_006918
SC5D	hsa-miR-3916	80.6737	NM_006918
SC5D	hsa-miR-4762-5p	80.3456	NM_006918
SC5D	hsa-miR-5189-5p	80.0709	NM_006918
SC5D	hsa-miR-1285-3p	80.0709	NM_006918

Page: 1

Top

Motifs and transcription factors (TFs) regulating SC5D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SC5D	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SC5D	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SC5D	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SC5D	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SC5D	transfac_pro__M04617	ZBTB7A (directAnnotation).
SC5D	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SC5D	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
SC5D	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SC5D	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SC5D	transfac_pro__M07387	ZBTB7A (directAnnotation).
SC5D	transfac_pro__M07436	WT1 (directAnnotation).
SC5D	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SC5D	transfac_pro__M00716	ZBTB14 (directAnnotation).
SC5D	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SC5D	hdpi__HIP2	UBE2K (directAnnotation).
SC5D	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SC5D	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SC5D	transfac_pro__M04893	TAF1 (directAnnotation).
SC5D	transfac_pro__M03876	ZBTB33 (directAnnotation).
SC5D	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SC5D	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SC5D	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SC5D	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SC5D	transfac_pro__M01861	ATF1 (directAnnotation).
SC5D	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
SC5D	cisbp__M04023	CREB1 (directAnnotation).
SC5D	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SC5D	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
SC5D	transfac_pro__M02089	E2F3 (directAnnotation).
SC5D	hdpi__NRL	NRL (directAnnotation).
SC5D	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SC5D	transfac_pro__M04817	ZBTB33 (directAnnotation).
SC5D	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SC5D	transfac_pro__M01199	TRIM28 (directAnnotation).
SC5D	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SC5D	transfac_pro__M07329	SP7 (directAnnotation).
SC5D	transfac_pro__M00938	E2F1 (directAnnotation).
SC5D	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SC5D	transfac_pro__M02898	SMAD3 (directAnnotation).
SC5D	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SC5D	metacluster_3.14	WT1; WT1 (directAnnotation).
SC5D	cisbp__M07938	E2F1 (directAnnotation).
SC5D	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SC5D	transfac_pro__M01253	CNOT3 (directAnnotation).
SC5D	transfac_pro__M07310	SP5 (directAnnotation).
SC5D	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."