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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SBNO1

Summary for SBNO1

Gene information	Gene symbol	SBNO1
	Ensembl ID	ENSG00000139697
	Entrez ID	55206
	Gene name	strawberry notch homolog 1
	Synonyms	FLJ10701\|FLJ10833\|MOP3\|Sno
	Gene type	protein_coding
	UniProtAcc	A3KN83

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Dataset with differentially expressed gene: SBNO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.330715	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.4516	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.279656	0.00e+00

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Expression of SBNO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SBNO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SBNO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SBNO1	hsa-miR-493-5p	99.5002	NM_001167856
SBNO1	hsa-miR-5011-5p	99.387	NM_001167856
SBNO1	hsa-miR-3613-3p	98.1942	NM_001167856
SBNO1	hsa-miR-4319	96.562	NM_001167856
SBNO1	hsa-miR-641	95.7505	NM_001167856
SBNO1	hsa-miR-3617-5p	95.7505	NM_001167856
SBNO1	hsa-miR-1184	95.7484	NM_001167856
SBNO1	hsa-miR-570-3p	95.5096	NM_001167856
SBNO1	hsa-miR-4643	95.4421	NM_001167856
SBNO1	hsa-miR-140-5p	95.2762	NM_001167856
SBNO1	hsa-miR-323a-3p	94.9023	NM_001167856
SBNO1	hsa-miR-495-5p	94.7861	NM_001167856
SBNO1	hsa-miR-125b-5p	94.763	NM_001167856
SBNO1	hsa-miR-125a-5p	94.763	NM_001167856
SBNO1	hsa-miR-190a-3p	94.3914	NM_001167856
SBNO1	hsa-miR-4676-5p	94.3745	NM_001167856
SBNO1	hsa-miR-575	94.3745	NM_001167856
SBNO1	hsa-miR-6873-3p	94.0963	NM_001167856
SBNO1	hsa-miR-5003-3p	94.0201	NM_001167856
SBNO1	hsa-miR-382-5p	93.9511	NM_001167856
SBNO1	hsa-miR-3662	93.815	NM_001167856
SBNO1	hsa-miR-196a-1-3p	93.6279	NM_001167856
SBNO1	hsa-miR-1283	93.6085	NM_001167856
SBNO1	hsa-miR-8485	93.566	NM_001167856
SBNO1	hsa-miR-600	93.3828	NM_001167856
SBNO1	hsa-miR-5700	93.1801	NM_001167856
SBNO1	hsa-miR-3678-3p	92.9898	NM_001167856
SBNO1	hsa-miR-3120-3p	92.7203	NM_001167856
SBNO1	hsa-miR-3189-5p	92.6629	NM_001167856
SBNO1	hsa-miR-29a-5p	91.7862	NM_001167856
SBNO1	hsa-miR-6797-3p	91.6248	NM_001167856
SBNO1	hsa-miR-491-3p	91.1932	NM_001167856
SBNO1	hsa-miR-374c-5p	90.3363	NM_001167856
SBNO1	hsa-miR-655-3p	90.3363	NM_001167856
SBNO1	hsa-miR-6833-3p	90.299	NM_001167856
SBNO1	hsa-miR-2276-3p	90.236	NM_001167856
SBNO1	hsa-miR-107	90.0362	NM_001167856
SBNO1	hsa-miR-103a-3p	90.0362	NM_001167856
SBNO1	hsa-miR-1297	89.9713	NM_001167856
SBNO1	hsa-miR-548ao-5p	89.798	NM_001167856
SBNO1	hsa-miR-548ax	89.798	NM_001167856
SBNO1	hsa-miR-6828-5p	89.4944	NM_001167856
SBNO1	hsa-miR-1913	89.2126	NM_001167856
SBNO1	hsa-miR-4718	89.1576	NM_001167856
SBNO1	hsa-miR-6890-3p	89.1506	NM_001167856
SBNO1	hsa-miR-935	89.0784	NM_001167856
SBNO1	hsa-miR-137-3p	88.8547	NM_001167856
SBNO1	hsa-miR-9-5p	88.5865	NM_001167856
SBNO1	hsa-miR-6817-3p	88.473	NM_001167856
SBNO1	hsa-miR-5591-3p	88.2426	NM_001167856

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Motifs and transcription factors (TFs) regulating SBNO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."