Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SBF2

Summary for SBF2

Gene information	Gene symbol	SBF2
	Ensembl ID	ENSG00000133812
	Entrez ID	81846
	Gene name	SET binding factor 2
	Synonyms	CMT4B2\|DENND7B\|KIAA1766\|MTMR13
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: SBF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.333357	0.00e+00

Top

Expression of SBF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SBF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SBF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SBF2	hsa-miR-524-5p	99.6731	NM_030962
SBF2	hsa-miR-520d-5p	99.5977	NM_030962
SBF2	hsa-miR-302c-5p	98.4037	NM_030962
SBF2	hsa-miR-4671-3p	97.9626	NM_030962
SBF2	hsa-miR-27b-3p	97.4228	NM_030962
SBF2	hsa-miR-9985	97.4228	NM_030962
SBF2	hsa-miR-27a-3p	97.4228	NM_030962
SBF2	hsa-miR-454-3p	97.39	NM_030962
SBF2	hsa-miR-130b-3p	96.1356	NM_030962
SBF2	hsa-miR-4295	96.1356	NM_030962
SBF2	hsa-miR-301a-3p	96.1356	NM_030962
SBF2	hsa-miR-3666	96.1356	NM_030962
SBF2	hsa-miR-301b-3p	96.1356	NM_030962
SBF2	hsa-miR-130a-3p	96.1356	NM_030962
SBF2	hsa-miR-513a-5p	95.8552	NM_030962
SBF2	hsa-miR-4276	94.2107	NM_030962
SBF2	hsa-miR-5093	93.8262	NM_030962
SBF2	hsa-miR-4789-5p	91.9112	NM_030962
SBF2	hsa-miR-1283	91.5841	NM_030962
SBF2	hsa-miR-876-3p	91.2672	NM_030962
SBF2	hsa-miR-298	91.0495	NM_030962
SBF2	hsa-miR-6895-3p	90.6229	NM_030962
SBF2	hsa-miR-3143	90.3809	NM_030962
SBF2	hsa-miR-3138	90.3727	NM_030962
SBF2	hsa-miR-3973	90.0579	NM_030962
SBF2	hsa-miR-205-5p	88.9688	NM_030962
SBF2	hsa-miR-3192-3p	88.6158	NM_030962
SBF2	hsa-miR-19b-3p	88.4281	NM_030962
SBF2	hsa-miR-19a-3p	88.4281	NM_030962
SBF2	hsa-miR-3606-5p	87.7783	NM_030962
SBF2	hsa-miR-3182	87.3189	NM_030962
SBF2	hsa-miR-101-5p	87.2925	NM_030962
SBF2	hsa-miR-29a-5p	87.1948	NM_030962
SBF2	hsa-miR-4766-5p	86.0525	NM_030962
SBF2	hsa-miR-4711-5p	85.8418	NM_030962
SBF2	hsa-miR-656-3p	85.7176	NM_030962
SBF2	hsa-let-7b-3p	84.9118	NM_030962
SBF2	hsa-let-7f-1-3p	84.9118	NM_030962
SBF2	hsa-miR-98-3p	84.9118	NM_030962
SBF2	hsa-let-7a-3p	84.9118	NM_030962
SBF2	hsa-miR-9983-3p	84.5819	NM_030962
SBF2	hsa-miR-506-5p	84.0121	NM_030962
SBF2	hsa-miR-5003-3p	82.7246	NM_030962
SBF2	hsa-miR-3074-5p	82.6386	NM_030962
SBF2	hsa-miR-129-5p	81.77	NM_030962
SBF2	hsa-miR-4308	81.6813	NM_030962
SBF2	hsa-miR-138-2-3p	81.3561	NM_030962
SBF2	hsa-miR-4473	80.2297	NM_030962
SBF2	hsa-miR-148b-3p	80.1276	NM_030962
SBF2	hsa-miR-152-3p	80.1276	NM_030962

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating SBF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SBF2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SBF2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
SBF2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SBF2	cisbp__M00968	MTF2 (directAnnotation).
SBF2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SBF2	jaspar__MA1122.1	TFDP1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."