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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SATB2

Summary for SATB2

Gene information	Gene symbol	SATB2
	Ensembl ID	ENSG00000119042
	Entrez ID	23314
	Gene name	SATB homeobox 2
	Synonyms	FLJ21474\|KIAA1034
	Gene type	protein_coding
	UniProtAcc	Q9UPW6

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Dataset with differentially expressed gene: SATB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.70055	1.49e-02

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Expression of SATB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SATB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SATB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SATB2	hsa-miR-3613-3p	99.9947	NM_001172509
SATB2	hsa-miR-671-5p	99.5242	NM_001172509
SATB2	hsa-miR-3121-3p	99.4971	NM_001172509
SATB2	hsa-miR-5011-5p	98.9333	NM_015265
SATB2	hsa-miR-34c-5p	98.6831	NM_001172509
SATB2	hsa-miR-449b-5p	98.6831	NM_001172509
SATB2	hsa-miR-1277-5p	98.4993	NM_015265
SATB2	hsa-miR-4795-5p	98.4664	NM_001172509
SATB2	hsa-miR-449a	98.451	NM_001172509
SATB2	hsa-miR-34a-5p	98.451	NM_001172509
SATB2	hsa-miR-12127	97.9286	NM_001172509
SATB2	hsa-miR-5688	97.5858	NM_015265
SATB2	hsa-miR-211-3p	97.5269	NM_001172509
SATB2	hsa-miR-495-3p	97.3206	NM_015265
SATB2	hsa-miR-4786-3p	96.7412	NM_001172509
SATB2	hsa-miR-3616-5p	96.3927	NM_001172509
SATB2	hsa-miR-573	96.3927	NM_001172509
SATB2	hsa-miR-627-3p	95.9722	NM_015265
SATB2	hsa-miR-4441	94.2431	NM_001172509
SATB2	hsa-miR-607	94.0654	NM_001172509
SATB2	hsa-miR-4802-3p	93.5572	NM_015265
SATB2	hsa-miR-8485	93.3252	NM_001172509
SATB2	hsa-miR-4270	93.1924	NM_001172509
SATB2	hsa-miR-874-3p	93.1344	NM_001172509
SATB2	hsa-miR-527	93.1149	NM_001172509
SATB2	hsa-miR-518a-5p	93.1149	NM_001172509
SATB2	hsa-miR-1914-5p	93.1036	NM_015265
SATB2	hsa-miR-148b-5p	93.0291	NM_001172509
SATB2	hsa-miR-6874-3p	93.0291	NM_001172509
SATB2	hsa-miR-4724-5p	92.4257	NM_001172509
SATB2	hsa-miR-205-5p	92.3952	NM_001172509
SATB2	hsa-miR-520h	91.9385	NM_015265
SATB2	hsa-miR-520g-3p	91.9385	NM_015265
SATB2	hsa-miR-616-5p	91.6791	NM_015265
SATB2	hsa-miR-371b-5p	91.6791	NM_015265
SATB2	hsa-miR-373-5p	91.6791	NM_015265
SATB2	hsa-miR-450b-5p	91.6548	NM_001172509
SATB2	hsa-miR-23b-3p	91.5468	NM_001172509
SATB2	hsa-miR-23a-3p	91.5468	NM_001172509
SATB2	hsa-miR-23c	91.5468	NM_001172509
SATB2	hsa-miR-1251-3p	91.4564	NM_015265
SATB2	hsa-miR-500a-5p	90.7707	NM_015265
SATB2	hsa-miR-4476	89.8496	NM_001172509
SATB2	hsa-miR-6876-5p	89.8496	NM_001172509
SATB2	hsa-miR-4778-3p	89.5616	NM_015265
SATB2	hsa-miR-6754-5p	89.5355	NM_001172509
SATB2	hsa-miR-5047	89.179	NM_001172509
SATB2	hsa-miR-1301-3p	89.179	NM_001172509
SATB2	hsa-miR-7976	88.6209	NM_001172509
SATB2	hsa-miR-1184	88.5042	NM_001172509

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Motifs and transcription factors (TFs) regulating SATB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SATB2	transfac_pro__M07436	WT1 (directAnnotation).
SATB2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SATB2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SATB2	transfac_pro__M03876	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."