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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SATB1

Summary for SATB1

Gene information	Gene symbol	SATB1
	Ensembl ID	ENSG00000182568
	Entrez ID	6304
	Gene name	SATB homeobox 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q01826

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Dataset with differentially expressed gene: SATB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	4.1551	1.21e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.335474	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.437611	2.60e-34
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.34439	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.301451	1.11e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.355373	9.26e-10
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.267638	1.65e-03

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Expression of SATB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SATB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SATB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SATB1	hsa-miR-1185-1-3p	99.3473	NM_001131010
SATB1	hsa-let-7f-2-3p	99.3473	NM_001131010
SATB1	hsa-miR-1185-2-3p	99.3473	NM_001131010
SATB1	hsa-miR-6867-5p	99.3397	NM_001131010
SATB1	hsa-miR-5692a	97.2234	NM_001131010
SATB1	hsa-miR-3529-3p	97.0014	NM_001131010
SATB1	hsa-miR-4729	96.66	NM_001131010
SATB1	hsa-miR-19b-3p	96.1767	NM_001131010
SATB1	hsa-miR-19a-3p	96.1767	NM_001131010
SATB1	hsa-miR-302f	95.6318	NM_001131010
SATB1	hsa-miR-5688	95.2363	NM_001131010
SATB1	hsa-miR-3121-3p	95.0037	NM_001131010
SATB1	hsa-miR-23a-3p	94.4241	NM_001131010
SATB1	hsa-miR-23b-3p	94.4241	NM_001131010
SATB1	hsa-miR-23c	94.4241	NM_001131010
SATB1	hsa-miR-448	94.1138	NM_001131010
SATB1	hsa-miR-1283	93.951	NM_001131010
SATB1	hsa-miR-624-3p	93.7623	NM_001131010
SATB1	hsa-miR-548c-3p	93.5464	NM_001131010
SATB1	hsa-miR-548v	93.5263	NM_001131010
SATB1	hsa-miR-4789-5p	93.4974	NM_001131010
SATB1	hsa-miR-495-3p	92.8642	NM_001131010
SATB1	hsa-miR-3133	92.7821	NM_001131010
SATB1	hsa-miR-548s	92.7134	NM_001131010
SATB1	hsa-miR-186-5p	92.6757	NM_001131010
SATB1	hsa-miR-4762-3p	92.6232	NM_001131010
SATB1	hsa-miR-3680-3p	92.1619	NM_001131010
SATB1	hsa-miR-588	91.9533	NM_001131010
SATB1	hsa-miR-4701-5p	91.9533	NM_001131010
SATB1	hsa-miR-580-3p	91.8542	NM_001131010
SATB1	hsa-miR-10523-5p	91.4559	NM_001131010
SATB1	hsa-miR-98-3p	91.2411	NM_001131010
SATB1	hsa-let-7a-3p	91.2411	NM_001131010
SATB1	hsa-let-7b-3p	91.2411	NM_001131010
SATB1	hsa-let-7f-1-3p	91.2411	NM_001131010
SATB1	hsa-miR-302c-5p	90.5322	NM_001131010
SATB1	hsa-miR-20a-3p	90.0221	NM_001131010
SATB1	hsa-miR-153-3p	90.0039	NM_001131010
SATB1	hsa-miR-3926	89.7262	NM_001131010
SATB1	hsa-miR-2113	89.5032	NM_001131010
SATB1	hsa-miR-194-5p	89.136	NM_001131010
SATB1	hsa-miR-9983-3p	89.0463	NM_001131010
SATB1	hsa-miR-8068	88.9995	NM_001131010
SATB1	hsa-miR-129-5p	88.2885	NM_001131010
SATB1	hsa-miR-6806-3p	87.9461	NM_001131010
SATB1	hsa-miR-3928-5p	87.9461	NM_001131010
SATB1	hsa-miR-143-5p	87.9241	NM_001131010
SATB1	hsa-miR-5689	87.9239	NM_001131010
SATB1	hsa-miR-5584-3p	87.7456	NM_001131010
SATB1	hsa-miR-1-3p	87.2578	NM_001131010

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Motifs and transcription factors (TFs) regulating SATB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SATB1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SATB1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SATB1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SATB1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SATB1	transfac_pro__M04617	ZBTB7A (directAnnotation).
SATB1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SATB1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
SATB1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SATB1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SATB1	transfac_pro__M07387	ZBTB7A (directAnnotation).
SATB1	transfac_pro__M07436	WT1 (directAnnotation).
SATB1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SATB1	transfac_pro__M00716	ZBTB14 (directAnnotation).
SATB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SATB1	hdpi__HIP2	UBE2K (directAnnotation).
SATB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SATB1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SATB1	transfac_pro__M04893	TAF1 (directAnnotation).
SATB1	transfac_pro__M03876	ZBTB33 (directAnnotation).
SATB1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SATB1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SATB1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SATB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SATB1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SATB1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SATB1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SATB1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SATB1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SATB1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
SATB1	hdpi__TP73	TP73 (directAnnotation).
SATB1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SATB1	transfac_public__M00024	E2F1 (directAnnotation).
SATB1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SATB1	transfac_pro__M04826	EP300 (directAnnotation).
SATB1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SATB1	transfac_pro__M04950	EGR1 (directAnnotation).
SATB1	transfac_pro__M04944	GABPA (directAnnotation).
SATB1	jaspar__MA1933.1	SREBF2 (directAnnotation).
SATB1	transfac_pro__M00652	NRF1 (directAnnotation).
SATB1	cisbp__M02645	ETS1 (directAnnotation).
SATB1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
SATB1	transfac_pro__M05817	ZNF546 (directAnnotation).
SATB1	hdpi__ETV4	ETV4 (directAnnotation).
SATB1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SATB1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SATB1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
SATB1	transfac_pro__M00492	STAT1 (directAnnotation).
SATB1	transfac_pro__M01298	MECP2 (directAnnotation).
SATB1	transfac_pro__M02848	EGR1 (inferredBy_Orthology).
SATB1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."