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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SASS6

Summary for SASS6

Gene information	Gene symbol	SASS6
	Ensembl ID	ENSG00000156876
	Entrez ID	163786
	Gene name	SAS-6 centriolar assembly protein
	Synonyms	DKFZp761A078\|FLJ22097\|SAS-6\|SAS6
	Gene type	protein_coding
	UniProtAcc	Q6UVJ0

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Dataset with differentially expressed gene: SASS6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.445369	0.00e+00

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Expression of SASS6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SASS6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SASS6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SASS6	hsa-miR-4477a	98.6052	NM_001304829
SASS6	hsa-miR-433-3p	96.1128	NM_001304829
SASS6	hsa-miR-3143	95.012	NM_001304829
SASS6	hsa-miR-190a-3p	94.5951	NM_001304829
SASS6	hsa-miR-4446-5p	91.063	NM_001304829
SASS6	hsa-miR-374c-5p	91.0594	NM_001304829
SASS6	hsa-miR-655-3p	91.0594	NM_001304829
SASS6	hsa-miR-4469	89.3965	NM_001304829
SASS6	hsa-miR-30d-3p	88.8818	NM_001304829
SASS6	hsa-miR-30a-3p	88.8818	NM_001304829
SASS6	hsa-miR-30e-3p	88.8818	NM_001304829
SASS6	hsa-miR-3163	88.4444	NM_001304829
SASS6	hsa-miR-548x-3p	87.4819	NM_001304829
SASS6	hsa-miR-548aj-3p	87.4819	NM_001304829
SASS6	hsa-miR-211-5p	87.3725	NM_001304829
SASS6	hsa-miR-204-5p	87.3725	NM_001304829
SASS6	hsa-miR-4760-3p	87.1091	NM_001304829
SASS6	hsa-miR-585-5p	86.9301	NM_001304829
SASS6	hsa-miR-3662	86.7932	NM_001304829
SASS6	hsa-miR-548ai	86.7682	NM_001304829
SASS6	hsa-miR-548ba	86.7682	NM_001304829
SASS6	hsa-miR-570-5p	86.7682	NM_001304829
SASS6	hsa-miR-548ag	86.7682	NM_001304829
SASS6	hsa-miR-3180-5p	86.0325	NM_001304829
SASS6	hsa-miR-5585-5p	85.8524	NM_001304829
SASS6	hsa-miR-656-3p	85.7699	NM_001304829
SASS6	hsa-miR-548ae-3p	85.1603	NM_001304829
SASS6	hsa-miR-548aq-3p	85.1603	NM_001304829
SASS6	hsa-miR-5582-3p	84.817	NM_001304829
SASS6	hsa-miR-4643	84.3255	NM_001304829
SASS6	hsa-miR-548j-3p	83.1486	NM_001304829
SASS6	hsa-miR-548ah-3p	83.1486	NM_001304829
SASS6	hsa-miR-548am-3p	83.1486	NM_001304829
SASS6	hsa-miR-6715a-3p	83.0111	NM_001304829
SASS6	hsa-miR-3942-3p	82.5067	NM_001304829
SASS6	hsa-miR-4799-5p	82.3092	NM_001304829
SASS6	hsa-miR-5006-3p	82.0336	NM_001304829
SASS6	hsa-miR-4755-5p	82.0336	NM_001304829
SASS6	hsa-miR-510-3p	81.5285	NM_001304829
SASS6	hsa-miR-3124-3p	81.087	NM_001304829
SASS6	hsa-miR-548ar-3p	80.755	NM_001304829
SASS6	hsa-miR-4769-3p	80.6552	NM_001304829
SASS6	hsa-miR-6817-5p	80.6552	NM_001304829

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Motifs and transcription factors (TFs) regulating SASS6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SASS6	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SASS6	jaspar__MA1483.2	ELF2 (directAnnotation).
SASS6	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."