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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SAMD9L

Summary for SAMD9L

Gene information	Gene symbol	SAMD9L
	Ensembl ID	ENSG00000177409
	Entrez ID	219285
	Gene name	sterile alpha motif domain containing 9 like
	Synonyms	C7orf6\|FLJ39885\|KIAA2005
	Gene type	protein_coding
	UniProtAcc	Q8IVG5

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Dataset with differentially expressed gene: SAMD9L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.332606	1.03e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.343795	6.25e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.265496	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.478409	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.821269	1.75e-05

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Expression of SAMD9L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SAMD9L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SAMD9L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SAMD9L	hsa-miR-6867-5p	100	NM_001303500
SAMD9L	hsa-miR-548e-5p	93.8435	NM_001303500
SAMD9L	hsa-miR-552-3p	93.569	NM_001303500
SAMD9L	hsa-miR-3148	90.6635	NM_001303500
SAMD9L	hsa-miR-10527-5p	89.1116	NM_001303496
SAMD9L	hsa-miR-580-3p	88.2862	NM_001303496
SAMD9L	hsa-miR-513a-5p	87.4417	NM_001303500
SAMD9L	hsa-miR-8081	85.351	NM_001303500
SAMD9L	hsa-miR-10397-5p	83.4278	NM_001303500
SAMD9L	hsa-miR-3688-3p	82.8921	NM_001303500
SAMD9L	hsa-miR-5584-3p	82.2109	NM_001303500
SAMD9L	hsa-miR-135a-5p	81.4785	NM_001303500
SAMD9L	hsa-miR-135b-5p	81.4785	NM_001303500
SAMD9L	hsa-miR-128-3p	81.4505	NM_001303500
SAMD9L	hsa-miR-216a-3p	81.4505	NM_001303500

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Motifs and transcription factors (TFs) regulating SAMD9L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SAMD9L	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
SAMD9L	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SAMD9L	metacluster_22.11	NFE2 (directAnnotation).
SAMD9L	tfdimers__MD00026	IRF1; MYB (directAnnotation).
SAMD9L	metacluster_167.7	IRF8 (inferredBy_Orthology).
SAMD9L	metacluster_22.17	NFE2 (directAnnotation).
SAMD9L	metacluster_22.32	NFE2L2 (directAnnotation).
SAMD9L	metacluster_22.28	BACH1 (directAnnotation).
SAMD9L	transfac_pro__M06493	ZNF668 (inferredBy_Orthology).
SAMD9L	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
SAMD9L	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
SAMD9L	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
SAMD9L	transfac_pro__M05982	ZFP14 (directAnnotation).
SAMD9L	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
SAMD9L	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2	SPIB; TEAD4 (directAnnotation).
SAMD9L	metacluster_87.5	ZNF296 (directAnnotation).
SAMD9L	jaspar__MA1562.1	SOX14 (directAnnotation).
SAMD9L	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
SAMD9L	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SAMD9L	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
SAMD9L	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
SAMD9L	kznf__ZNF200_Najafabadi2015_ChIP-seq	ZNF200 (directAnnotation).
SAMD9L	kznf__ZBTB12_Schmitges2016_RCADE	ZBTB12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."