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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SAMD4B

Summary for SAMD4B

Gene information	Gene symbol	SAMD4B
	Ensembl ID	ENSG00000179134
	Entrez ID	55095
	Gene name	sterile alpha motif domain containing 4B
	Synonyms	FLJ10211\|hSmaug2\|MGC99832\|SMGB
	Gene type	protein_coding
	UniProtAcc	Q5PRF9

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Dataset with differentially expressed gene: SAMD4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.410672	5.03e-39
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.31756	9.37e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.334581	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.254217	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.259089	7.80e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.344175	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.334641	3.76e-34

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Expression of SAMD4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SAMD4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SAMD4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SAMD4B	hsa-miR-12123	99.2056	NM_018028
SAMD4B	hsa-miR-4511	96.5844	NM_001303614
SAMD4B	hsa-miR-664a-3p	95.5547	NM_018028
SAMD4B	hsa-miR-491-5p	95.2575	NM_001303614
SAMD4B	hsa-miR-548at-5p	94.7832	NM_018028
SAMD4B	hsa-miR-330-5p	94.6959	NM_001303614
SAMD4B	hsa-miR-326	93.056	NM_001303614
SAMD4B	hsa-miR-4255	92.08	NM_018028
SAMD4B	hsa-miR-4533	91.7384	NM_001303614
SAMD4B	hsa-miR-4725-3p	90.5993	NM_001303614
SAMD4B	hsa-miR-6780b-5p	90.5993	NM_001303614
SAMD4B	hsa-miR-4436b-5p	89.5205	NM_001303614
SAMD4B	hsa-miR-4271	89.2736	NM_001303614
SAMD4B	hsa-miR-6734-5p	88.8941	NM_001303614
SAMD4B	hsa-miR-4799-5p	88.7563	NM_018028
SAMD4B	hsa-miR-1275	88.6476	NM_018028
SAMD4B	hsa-miR-92a-2-5p	87.2458	NM_001303614
SAMD4B	hsa-miR-1295b-3p	86.6843	NM_001303614
SAMD4B	hsa-miR-766-5p	86.4728	NM_001303614
SAMD4B	hsa-miR-4433a-5p	85.603	NM_018028
SAMD4B	hsa-miR-6827-5p	85.2607	NM_018028
SAMD4B	hsa-miR-5196-5p	84.3701	NM_001303614
SAMD4B	hsa-miR-4747-5p	84.3701	NM_001303614
SAMD4B	hsa-miR-548b-3p	83.9017	NM_001303614
SAMD4B	hsa-miR-4665-5p	83.4389	NM_018028
SAMD4B	hsa-miR-4478	83.1444	NM_001303614
SAMD4B	hsa-miR-3662	82.9867	NM_001303614
SAMD4B	hsa-miR-4492	82.3643	NM_001303614
SAMD4B	hsa-miR-3925-5p	82.1619	NM_001303614
SAMD4B	hsa-miR-3918	81.7735	NM_018028
SAMD4B	hsa-miR-6892-3p	81.7439	NM_018028
SAMD4B	hsa-miR-423-5p	81.2237	NM_001303614
SAMD4B	hsa-miR-3184-5p	81.2237	NM_001303614
SAMD4B	hsa-miR-4450	80.9934	NM_001303614
SAMD4B	hsa-miR-4441	80.9853	NM_018028
SAMD4B	hsa-miR-18a-3p	80.9011	NM_018028
SAMD4B	hsa-miR-6856-5p	80.8808	NM_001303614

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Motifs and transcription factors (TFs) regulating SAMD4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SAMD4B	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
SAMD4B	metacluster_151.2	ZNF23 (directAnnotation).
SAMD4B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SAMD4B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SAMD4B	transfac_pro__M01973	PLAG1 (directAnnotation).
SAMD4B	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
SAMD4B	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."