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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: S1PR3

Summary for S1PR3

Gene information	Gene symbol	S1PR3
	Ensembl ID	ENSG00000213694
	Entrez ID	1903
	Gene name	sphingosine-1-phosphate receptor 3
	Synonyms	bA791O21.3\|C9orf108\|C9orf47\|EDG-3\|EDG3\|FLJ37523
	Gene type	protein_coding
	UniProtAcc	Q99500

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Dataset with differentially expressed gene: S1PR3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.252211	1.65e-10

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Expression of S1PR3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to S1PR3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating S1PR3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
S1PR3	hsa-miR-4795-3p	100	NM_005226
S1PR3	hsa-miR-126-5p	99.9966	NM_005226
S1PR3	hsa-miR-576-5p	97.5399	NM_005226
S1PR3	hsa-miR-5688	95.907	NM_005226
S1PR3	hsa-miR-5003-3p	94.9228	NM_005226
S1PR3	hsa-miR-495-3p	94.8527	NM_005226
S1PR3	hsa-miR-9983-3p	93.3308	NM_005226
S1PR3	hsa-miR-142-3p	91.9634	NM_005226
S1PR3	hsa-miR-129-5p	91.1459	NM_005226
S1PR3	hsa-miR-1184	90.0411	NM_005226
S1PR3	hsa-miR-627-3p	85.3078	NM_005226
S1PR3	hsa-miR-6740-3p	84.4008	NM_005226
S1PR3	hsa-miR-450a-2-3p	84.3763	NM_005226
S1PR3	hsa-miR-4719	83.2994	NM_005226
S1PR3	hsa-miR-2110	82.3757	NM_005226
S1PR3	hsa-miR-3182	82.2527	NM_005226
S1PR3	hsa-miR-6892-3p	80.5431	NM_005226

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Motifs and transcription factors (TFs) regulating S1PR3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
S1PR3	"Fingolimod"	DB08868	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."