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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RYK

Summary for RYK

Gene information	Gene symbol	RYK
	Ensembl ID	ENSG00000163785
	Entrez ID	6259
	Gene name	receptor like tyrosine kinase
	Synonyms	D3S3195\|JTK5\|JTK5A\|RYK1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RYK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.272201	2.19e-18
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.29684	2.87e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.414203	0.00e+00

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Expression of RYK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RYK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RYK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RYK	hsa-miR-6513-3p	96.5345	NM_002958
RYK	hsa-miR-6508-5p	96.0591	NM_001005861
RYK	hsa-miR-4714-3p	95.9574	NM_002958
RYK	hsa-miR-3926	95.5594	NM_002958
RYK	hsa-miR-8067	95.082	NM_001005861
RYK	hsa-miR-548az-5p	95.0742	NM_001005861
RYK	hsa-miR-548t-5p	95.0742	NM_001005861
RYK	hsa-miR-7-5p	94.9075	NM_001005861
RYK	hsa-miR-548s	94.475	NM_002958
RYK	hsa-miR-548x-3p	93.3673	NM_002958
RYK	hsa-miR-548aj-3p	93.3673	NM_002958
RYK	hsa-miR-548ao-5p	92.8723	NM_002958
RYK	hsa-miR-548ax	92.8723	NM_002958
RYK	hsa-miR-4307	92.8125	NM_001005861
RYK	hsa-miR-1299	92.6548	NM_001005861
RYK	hsa-miR-548j-3p	92.4999	NM_002958
RYK	hsa-miR-548am-3p	92.4999	NM_002958
RYK	hsa-miR-548ae-3p	92.4999	NM_002958
RYK	hsa-miR-548ah-3p	92.4999	NM_002958
RYK	hsa-miR-548aq-3p	92.4999	NM_002958
RYK	hsa-miR-4282	92.0228	NM_002958
RYK	hsa-miR-4422	91.6221	NM_001005861
RYK	hsa-miR-6738-3p	90.2086	NM_002958
RYK	hsa-miR-5582-3p	87.0336	NM_002958
RYK	hsa-miR-4775	86.9889	NM_002958
RYK	hsa-miR-506-3p	86.7011	NM_001005861
RYK	hsa-miR-520a-5p	86.3918	NM_002958
RYK	hsa-miR-525-5p	86.3918	NM_002958
RYK	hsa-miR-1297	84.7207	NM_002958
RYK	hsa-miR-3152-3p	84.6488	NM_002958
RYK	hsa-miR-4420	84.6352	NM_002958
RYK	hsa-miR-181b-3p	84.6352	NM_002958
RYK	hsa-miR-181b-2-3p	84.6352	NM_002958
RYK	hsa-miR-548n	84.3936	NM_001005861
RYK	hsa-miR-124-3p	84.1182	NM_001005861
RYK	hsa-miR-4727-5p	83.5694	NM_002958
RYK	hsa-miR-452-5p	82.8955	NM_002958
RYK	hsa-miR-892c-3p	82.8955	NM_002958
RYK	hsa-miR-4676-3p	82.8955	NM_002958
RYK	hsa-miR-26a-5p	82.3055	NM_002958
RYK	hsa-miR-26b-5p	82.3055	NM_002958
RYK	hsa-miR-3609	81.287	NM_001005861
RYK	hsa-miR-548ah-5p	81.287	NM_001005861
RYK	hsa-miR-4465	81.0236	NM_002958
RYK	hsa-miR-6077	80.8998	NM_001005861

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Motifs and transcription factors (TFs) regulating RYK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RYK	metacluster_151.2	ZNF23 (directAnnotation).
RYK	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RYK	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RYK	transfac_pro__M06071	ZNF814 (directAnnotation).
RYK	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RYK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RYK	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RYK	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RYK	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RYK	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RYK	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
RYK	transfac_pro__M01253	CNOT3 (directAnnotation).
RYK	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RYK	transfac_pro__M05712	ZNF134 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."