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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor

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Acts as a drug target

Gene: RXRA

Summary for RXRA

Gene informationGene symbol

RXRA

Ensembl ID

ENSG00000186350

Entrez ID

6256

Gene nameretinoid X receptor alpha
SynonymsNR2B1|RXR-alpha|RXRalpha
Gene typeprotein_coding
UniProtAcc

P19793


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Dataset with differentially expressed gene: RXRA

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preMono/Macro0.3326510.00e+00

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.2739490.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.2910730.00e+00

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.3582811.47e-25

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.5449930.00e+00

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.2799426.34e-12

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.3491062.99e-14

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Expression of RXRA in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to RXRA

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RXRA

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
RXRAhsa-miR-4723-3p97.0591NM_001291920
RXRAhsa-miR-6769b-3p96.6151NM_001291920
RXRAhsa-miR-318396.5524NM_001291920
RXRAhsa-let-7c-3p95.0495NM_001291920
RXRAhsa-miR-3121-3p94.5103NM_001291920
RXRAhsa-miR-1207-5p92.9821NM_002957
RXRAhsa-miR-574-3p92.354NM_001291920
RXRAhsa-miR-9-5p91.851NM_001291920
RXRAhsa-miR-4763-3p91.6475NM_002957
RXRAhsa-miR-7111-3p91.5787NM_001291920
RXRAhsa-miR-1224-3p91.4037NM_001291920
RXRAhsa-miR-4433a-5p91.1563NM_001291920
RXRAhsa-miR-1260b90.42NM_001291920
RXRAhsa-miR-1260a90.42NM_001291920
RXRAhsa-miR-450590.2638NM_002957
RXRAhsa-miR-578787.8518NM_002957
RXRAhsa-miR-6747-3p86.7084NM_001291920
RXRAhsa-miR-493-5p86.4692NM_001291920
RXRAhsa-let-7a-2-3p85.2557NM_001291920
RXRAhsa-let-7g-3p85.2557NM_001291920
RXRAhsa-miR-4755-3p84.8578NM_001291920
RXRAhsa-miR-6501-3p84.1879NM_001291920
RXRAhsa-miR-124-3p82.9612NM_001291920
RXRAhsa-miR-506-3p82.9612NM_001291920
RXRAhsa-miR-197282.8195NM_001291920
RXRAhsa-miR-10527-5p82.7994NM_001291920
RXRAhsa-miR-194-5p82.5465NM_002957
RXRAhsa-miR-391082.1022NM_001291920
RXRAhsa-miR-3692-3p81.5561NM_001291920
RXRAhsa-miR-797781.3688NM_001291920
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Motifs and transcription factors (TFs) regulating RXRA

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RXRAtaipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
RXRAtaipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_reprE2F2 (directAnnotation).
RXRAcisbp__M08198ELF1 (directAnnotation).
RXRAtaipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
RXRAtransfac_pro__M04866HDAC2 (directAnnotation).
RXRAmetacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RXRAswissregulon__hs__ELF2ELF2 (directAnnotation).
RXRAswissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
RXRAtaipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAPCEBPD; ETV5 (directAnnotation).
RXRAdbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
RXRAstark__RCGCMATTWYY1 (inferredBy_Orthology).
RXRAtransfac_pro__M04918EGR1 (directAnnotation).
RXRAtaipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1SPIB; TEAD4 (directAnnotation).
RXRAhomer__ATTGCGCAAC_CEBPCEBPB (inferredBy_Orthology).
RXRAtransfac_pro__M04722SPI1 (directAnnotation).
RXRAjaspar__MA1509.1IRF6 (directAnnotation).
RXRAmetacluster_9.47PAX7 (inferredBy_Orthology).
RXRAtaipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAPELK1; SPDEF (directAnnotation).
RXRAmetacluster_46.4CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
RXRAtfdimers__MD00488ELF1; HDX (directAnnotation).
RXRAtfdimers__MD00034PDX1; SOX2 (directAnnotation).
RXRAmetacluster_2.8IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
RXRAmetacluster_22.33MAFK (inferredBy_Orthology).
RXRAtaipale_cyt_meth__IRF6_ACCGAWACY_FL_methIRF6 (directAnnotation).
RXRAtfdimers__MD00476BACH1; BACH2; FOXG1; FOXO1; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2L1; NFE2L2; NFE2L3 (directAnnotation).
RXRAmetacluster_22.37BACH1 (directAnnotation).
RXRAmetacluster_22.1MAFF (inferredBy_Orthology).
RXRAtaipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAPETV2; SPDEF (directAnnotation).
RXRAtransfac_pro__M12556ETV4 (directAnnotation).
RXRAtaipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAPFLI1; MAX (directAnnotation).
RXRAtfdimers__MD00591SRY; TFAP2C (directAnnotation).
RXRAtaipale_tf_pairs__RFX3_ETV7_NNNMGGAANNNNNTCCNNNRCAACN_CAP_reprETV7; RFX3 (directAnnotation).
RXRAkznf__ZNF571_Imbeault2017_OM_RCADEZNF571 (directAnnotation).
RXRAmetacluster_144.8ZNF30; ZNF30 (directAnnotation).
RXRAkznf__ZNF100_Imbeault2017_RP_RCADEZNF100 (directAnnotation).
RXRAjaspar__MA1721.1ZNF93 (directAnnotation).
RXRAdbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1ZBTB8A (directAnnotation).
RXRAtransfac_pro__M01253CNOT3 (directAnnotation).
RXRAswissregulon__hs__CHD1CHD1 (directAnnotation).
RXRAcisbp__M01863ZNF711 (inferredBy_Orthology).
RXRAtaipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
RXRAmetacluster_175.1ZNF283 (directAnnotation).
RXRAmetacluster_23.9GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RXRAtaipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_reprGCM1; SPDEF (directAnnotation).
RXRAkznf__ZNF2_Imbeault2017_OM_RCADEZNF2 (directAnnotation).
RXRAkznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
RXRAtaipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_methE2F2 (directAnnotation).
RXRAmetacluster_22.12NFE2; NFE2L1 (directAnnotation).
RXRAmetacluster_22.25NFE2L2 (directAnnotation).
RXRAmetacluster_30.4BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.
TFmotifExpressionCell typeDatasetTimepoint
RXRAmetacluster_196.3downMalignant cells

GSE199333

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
RXRA"1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE"

DB08063

small molecule
RXRA"2-chloro-5-nitro-N-phenylbenzamide"

DB07863

small molecule
RXRA"2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID"

DB08402

small molecule
RXRA"3,20-Pregnanedione"

DB07557

small molecule
RXRA"Acitretin"

DB00459

small molecule
RXRA"Adapalene"

DB00210

small molecule
RXRA"Alfacalcidol"

DB01436

small molecule
RXRA"Alitretinoin"

DB00523

small molecule
RXRA"alpha-Linolenic acid"

DB00132

small molecule
RXRA"Arachidonic Acid"

DB04557

small molecule
RXRA"Bexarotene"

DB00307

small molecule
RXRA"Bezafibrate"

DB01393

small molecule
RXRA"Doconexent"

DB03756

small molecule
RXRA"Etodolac"

DB00749

small molecule
RXRA"Etretinate"

DB00926

small molecule
RXRA"EVT-101"

DB05956

small molecule
RXRA"Oleic Acid"

DB04224

small molecule
RXRA"Phthalic Acid"

DB02746

small molecule
RXRA"Rosiglitazone"

DB00412

small molecule
RXRA"Tretinoin"

DB00755

small molecule
RXRA"Tributyltin"

DB08601

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."