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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RUBCN

Summary for RUBCN

Gene information	Gene symbol	RUBCN
	Ensembl ID	ENSG00000145016
	Entrez ID	9711
	Gene name	rubicon autophagy regulator
	Synonyms	KIAA0226\|rubicon\|rundataxin
	Gene type	protein_coding
	UniProtAcc	Q92622

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Dataset with differentially expressed gene: RUBCN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.589625	4.84e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.311231	0.00e+00

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Expression of RUBCN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RUBCN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RUBCN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RUBCN	hsa-miR-4277	96.4354	NM_001145642
RUBCN	hsa-miR-3619-5p	95.1886	NM_001145642
RUBCN	hsa-miR-214-3p	94.7184	NM_001145642
RUBCN	hsa-miR-761	94.6095	NM_001145642
RUBCN	hsa-miR-302e	93.9151	NM_001145642
RUBCN	hsa-miR-3682-3p	93.5504	NM_001145642
RUBCN	hsa-miR-6847-5p	93.4431	NM_001145642
RUBCN	hsa-miR-24-3p	90.6998	NM_001145642
RUBCN	hsa-miR-4310	90.2985	NM_001145642
RUBCN	hsa-miR-4441	89.0937	NM_001145642
RUBCN	hsa-miR-520b-3p	88.4037	NM_001145642
RUBCN	hsa-miR-520c-3p	88.4037	NM_001145642
RUBCN	hsa-miR-520a-3p	88.4037	NM_001145642
RUBCN	hsa-miR-373-3p	88.4037	NM_001145642
RUBCN	hsa-miR-520d-3p	88.4037	NM_001145642
RUBCN	hsa-miR-372-3p	88.4037	NM_001145642
RUBCN	hsa-miR-520e-3p	88.4037	NM_001145642
RUBCN	hsa-miR-302c-3p	88.2339	NM_001145642
RUBCN	hsa-miR-302b-3p	88.2339	NM_001145642
RUBCN	hsa-miR-302d-3p	88.2339	NM_001145642
RUBCN	hsa-miR-302a-3p	88.2339	NM_001145642
RUBCN	hsa-miR-4797-5p	87.9505	NM_001145642
RUBCN	hsa-miR-204-5p	85.9203	NM_001145642
RUBCN	hsa-miR-211-5p	85.9203	NM_001145642
RUBCN	hsa-miR-2115-5p	84.6476	NM_001145642
RUBCN	hsa-miR-651-3p	83.8	NM_001145642
RUBCN	hsa-miR-7157-5p	83.5555	NM_001145642
RUBCN	hsa-miR-519b-3p	83.5208	NM_001145642
RUBCN	hsa-miR-519a-3p	83.5208	NM_001145642
RUBCN	hsa-miR-519c-3p	83.5208	NM_001145642
RUBCN	hsa-miR-4291	82.8435	NM_001145642
RUBCN	hsa-miR-3977	81.0675	NM_001145642
RUBCN	hsa-miR-211-3p	80.7278	NM_001145642
RUBCN	hsa-miR-4270	80.2677	NM_001145642
RUBCN	hsa-miR-4755-3p	80.0424	NM_001145642
RUBCN	hsa-miR-4653-5p	80.0103	NM_001145642
RUBCN	hsa-miR-3921	80.0103	NM_001145642

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Motifs and transcription factors (TFs) regulating RUBCN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RUBCN	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
RUBCN	transfac_pro__M08803	CREM (directAnnotation).
RUBCN	metacluster_172.3	SMAD7 (directAnnotation). SMAD7 (inferredBy_Orthology).
RUBCN	metacluster_135.9	ZNF699 (directAnnotation).
RUBCN	transfac_pro__M06218	ZNF169 (directAnnotation).
RUBCN	metacluster_70.21	POU3F1 (directAnnotation).
RUBCN	metacluster_70.16	POU5F1; POU5F1 (directAnnotation).
RUBCN	transfac_pro__M05892	ZNF768 (inferredBy_Orthology).
RUBCN	metacluster_70.11	POU2F2 (directAnnotation).
RUBCN	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
RUBCN	transfac_pro__M06072	ZNF623 (directAnnotation).
RUBCN	transfac_pro__M05573	ZNF213 (directAnnotation).
RUBCN	metacluster_70.22	POU3F2 (directAnnotation).
RUBCN	metacluster_84.18	RARA (directAnnotation).
RUBCN	transfac_pro__M05404	ZNF445 (inferredBy_Orthology).
RUBCN	transfac_pro__M05521	ZNF398 (directAnnotation).
RUBCN	metacluster_70.17	POU1F1 (directAnnotation).
RUBCN	transfac_pro__M06025	ZNF195 (directAnnotation).
RUBCN	tfdimers__MD00052	GFI1; GFI1B; YY1 (directAnnotation).
RUBCN	metacluster_84.17	RARA (inferredBy_Orthology).
RUBCN	metacluster_70.24	POU3F2 (directAnnotation).
RUBCN	transfac_pro__M01229	GTF2IRD1 (directAnnotation).
RUBCN	metacluster_84.15	RARB (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."