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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RSU1

Summary for RSU1

Gene information	Gene symbol	RSU1
	Ensembl ID	ENSG00000148484
	Entrez ID	6251
	Gene name	Ras suppressor protein 1
	Synonyms	FLJ31034\|RSP-1
	Gene type	protein_coding
	UniProtAcc	Q15404

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Dataset with differentially expressed gene: RSU1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.479709	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.893407	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.251672	0.00e+00

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Expression of RSU1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RSU1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RSU1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RSU1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RSU1	hsa-miR-3646	94.6016	NM_012425
RSU1	hsa-miR-6839-3p	93.901	NM_152724
RSU1	hsa-miR-124-5p	92.4392	NM_152724
RSU1	hsa-miR-6870-5p	91.675	NM_152724
RSU1	hsa-miR-5698	91.675	NM_152724
RSU1	hsa-miR-4723-5p	91.675	NM_152724
RSU1	hsa-miR-7111-5p	91.675	NM_152724
RSU1	hsa-miR-5586-3p	89.4275	NM_152724
RSU1	hsa-miR-3689e	83.9985	NM_152724
RSU1	hsa-miR-3689a-5p	83.9985	NM_152724
RSU1	hsa-miR-3689f	83.9985	NM_152724
RSU1	hsa-miR-3689b-5p	83.9985	NM_152724
RSU1	hsa-miR-384	83.9004	NM_152724
RSU1	hsa-miR-516a-3p	83.8383	NM_152724
RSU1	hsa-miR-516b-3p	83.8383	NM_152724
RSU1	hsa-miR-7162-5p	83.8383	NM_152724
RSU1	hsa-miR-421	83.5544	NM_152724
RSU1	hsa-miR-4693-3p	82.9334	NM_152724
RSU1	hsa-miR-6853-3p	82.6454	NM_152724
RSU1	hsa-miR-4775	82.1953	NM_152724
RSU1	hsa-miR-4306	80.5615	NM_152724

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Motifs and transcription factors (TFs) regulating RSU1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RSU1	transfac_pro__M06074	ZNF732 (directAnnotation).
RSU1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RSU1	jaspar__MA1483.2	ELF2 (directAnnotation).
RSU1	hdpi__FLI1	FLI1 (directAnnotation).
RSU1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RSU1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RSU1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RSU1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RSU1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
RSU1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
RSU1	cisbp__M02645	ETS1 (directAnnotation).
RSU1	jaspar__MA1708.1	ETV7 (directAnnotation).
RSU1	hdpi__ETV4	ETV4 (directAnnotation).
RSU1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
RSU1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
RSU1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RSU1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RSU1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
RSU1	jaspar__MA1957.1	ELK1 (directAnnotation).
RSU1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
RSU1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
RSU1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RSU1	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
RSU1	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."