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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RSPO3

Summary for RSPO3

Gene information	Gene symbol	RSPO3
	Ensembl ID	ENSG00000146374
	Entrez ID	84870
	Gene name	R-spondin 3
	Synonyms	FLJ14440\|THSD2
	Gene type	protein_coding
	UniProtAcc	Q9BXY4

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Dataset with differentially expressed gene: RSPO3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-3.85068	2.03e-09

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Expression of RSPO3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RSPO3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RSPO3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RSPO3	hsa-miR-4659a-3p	99.3614	NM_032784
RSPO3	hsa-miR-4659b-3p	99.3614	NM_032784
RSPO3	hsa-miR-6875-3p	98.817	NM_032784
RSPO3	hsa-miR-6083	97.2404	NM_032784
RSPO3	hsa-miR-4729	96.5577	NM_032784
RSPO3	hsa-miR-4795-3p	96.5301	NM_032784
RSPO3	hsa-miR-6864-5p	92.9193	NM_032784
RSPO3	hsa-miR-548f-5p	92.8151	NM_032784
RSPO3	hsa-miR-548g-5p	92.8151	NM_032784
RSPO3	hsa-miR-548aj-5p	92.8151	NM_032784
RSPO3	hsa-miR-548x-5p	92.8151	NM_032784
RSPO3	hsa-miR-511-5p	91.8509	NM_032784
RSPO3	hsa-miR-4282	90.9925	NM_032784
RSPO3	hsa-miR-5088-3p	90.5749	NM_032784
RSPO3	hsa-miR-27a-3p	90.0891	NM_032784
RSPO3	hsa-miR-27b-3p	90.0891	NM_032784
RSPO3	hsa-miR-9985	90.0891	NM_032784
RSPO3	hsa-miR-6835-3p	88.6724	NM_032784
RSPO3	hsa-miR-5696	87.4186	NM_032784
RSPO3	hsa-miR-188-5p	87.2059	NM_032784
RSPO3	hsa-miR-6866-3p	87.2059	NM_032784
RSPO3	hsa-miR-153-5p	86.7896	NM_032784
RSPO3	hsa-miR-6716-5p	86.4708	NM_032784
RSPO3	hsa-miR-15a-5p	86.3652	NM_032784
RSPO3	hsa-miR-16-5p	86.3652	NM_032784
RSPO3	hsa-miR-195-5p	86.3652	NM_032784
RSPO3	hsa-miR-15b-5p	86.3652	NM_032784
RSPO3	hsa-miR-7151-3p	85.0909	NM_032784
RSPO3	hsa-miR-627-5p	84.4774	NM_032784
RSPO3	hsa-miR-126-5p	84.041	NM_032784
RSPO3	hsa-miR-6832-3p	83.911	NM_032784
RSPO3	hsa-miR-103a-1-5p	83.2625	NM_032784
RSPO3	hsa-miR-103a-2-5p	83.2625	NM_032784
RSPO3	hsa-miR-6728-5p	82.3907	NM_032784
RSPO3	hsa-miR-4516	82.1539	NM_032784
RSPO3	hsa-miR-2052	82.1302	NM_032784
RSPO3	hsa-miR-4680-3p	81.9883	NM_032784
RSPO3	hsa-miR-7-1-3p	81.0674	NM_032784
RSPO3	hsa-miR-7-2-3p	81.0674	NM_032784
RSPO3	hsa-miR-424-5p	80.8858	NM_032784
RSPO3	hsa-miR-6838-5p	80.8858	NM_032784
RSPO3	hsa-miR-497-5p	80.8858	NM_032784
RSPO3	hsa-miR-6719-3p	80.6382	NM_032784
RSPO3	hsa-miR-95-5p	80.5598	NM_032784

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Motifs and transcription factors (TFs) regulating RSPO3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."