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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RRM2B

Summary for RRM2B

Gene information	Gene symbol	RRM2B
	Ensembl ID	ENSG00000048392
	Entrez ID	50484
	Gene name	ribonucleotide reductase regulatory TP53 inducible subunit M2B
	Synonyms	p53R2
	Gene type	protein_coding
	UniProtAcc	Q7LG56

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Dataset with differentially expressed gene: RRM2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.25856	3.46e-10

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Expression of RRM2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RRM2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RRM2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RRM2B	hsa-miR-205-3p	99.5026	NM_001172477
RRM2B	hsa-miR-7856-5p	97.0084	NM_015713
RRM2B	hsa-miR-6777-3p	94.3418	NM_015713
RRM2B	hsa-miR-4425	94.0199	NM_015713
RRM2B	hsa-miR-3613-3p	92.5142	NM_015713
RRM2B	hsa-miR-545-3p	90.8511	NM_015713
RRM2B	hsa-miR-4311	90.8497	NM_015713
RRM2B	hsa-miR-137-3p	90.4034	NM_015713
RRM2B	hsa-miR-153-5p	89.9633	NM_001172477
RRM2B	hsa-miR-6864-5p	89.667	NM_015713
RRM2B	hsa-miR-4325	89.6192	NM_015713
RRM2B	hsa-miR-6074	88.7587	NM_015713
RRM2B	hsa-miR-548k	88.1799	NM_015713
RRM2B	hsa-miR-548av-5p	88.1799	NM_015713
RRM2B	hsa-miR-8054	88.1799	NM_015713
RRM2B	hsa-miR-4775	88.1739	NM_015713
RRM2B	hsa-miR-4328	87.9358	NM_015713
RRM2B	hsa-miR-3908	87.7175	NM_015713
RRM2B	hsa-let-7c-3p	86.947	NM_015713
RRM2B	hsa-miR-548l	86.417	NM_001172477
RRM2B	hsa-miR-340-5p	85.6834	NM_001172477
RRM2B	hsa-miR-1252-3p	85.3755	NM_001172477
RRM2B	hsa-miR-1277-5p	85.0462	NM_015713
RRM2B	hsa-miR-548c-3p	84.849	NM_001172477
RRM2B	hsa-miR-548e-5p	84.7032	NM_001172477
RRM2B	hsa-miR-5692a	84.006	NM_001172477
RRM2B	hsa-miR-2467-3p	83.2864	NM_015713
RRM2B	hsa-miR-5011-5p	82.9008	NM_015713
RRM2B	hsa-miR-4282	82.6083	NM_015713
RRM2B	hsa-miR-16-1-3p	82.0605	NM_015713
RRM2B	hsa-miR-7159-3p	81.6661	NM_015713
RRM2B	hsa-miR-4477b	81.6308	NM_015713
RRM2B	hsa-miR-6837-3p	81.0403	NM_015713
RRM2B	hsa-miR-651-3p	80.7401	NM_015713
RRM2B	hsa-miR-216b-5p	80.0842	NM_001172477

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Motifs and transcription factors (TFs) regulating RRM2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RRM2B	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
RRM2B	transfac_pro__M05896	ZNF713 (directAnnotation).
RRM2B	hdpi__FLI1	FLI1 (directAnnotation).
RRM2B	transfac_pro__M05908	ZNF319 (inferredBy_Orthology).
RRM2B	taipale_tf_pairs__POU2F1_DLX2_TGMATATKCANNNNNTAATKR_CAP_repr	DLX2; POU2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RRM2B	"Cladribine"	DB00242	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."