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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RRAS2

Summary for RRAS2

Gene information	Gene symbol	RRAS2
	Ensembl ID	ENSG00000133818
	Entrez ID	22800
	Gene name	RAS related 2
	Synonyms	TC21
	Gene type	protein_coding
	UniProtAcc	P62070

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Dataset with differentially expressed gene: RRAS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.353543	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.351405	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.297507	7.20e-22

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Expression of RRAS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RRAS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RRAS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RRAS2	hsa-miR-520d-5p	99.1158	NM_001102669
RRAS2	hsa-miR-524-5p	99.1158	NM_001102669
RRAS2	hsa-miR-3609	97.7612	NM_001102669
RRAS2	hsa-miR-548ah-5p	97.7612	NM_001102669
RRAS2	hsa-miR-4521	97.6885	NM_001102669
RRAS2	hsa-miR-548az-5p	96.6392	NM_001102669
RRAS2	hsa-miR-548t-5p	96.6392	NM_001102669
RRAS2	hsa-miR-223-3p	96.6173	NM_001102669
RRAS2	hsa-miR-3613-5p	95.6942	NM_001102669
RRAS2	hsa-miR-3161	95.5515	NM_001177314
RRAS2	hsa-miR-548n	95.1144	NM_001102669
RRAS2	hsa-miR-7-5p	94.2937	NM_001102669
RRAS2	hsa-miR-4789-5p	93.8709	NM_001102669
RRAS2	hsa-miR-23c	93.1193	NM_001177314
RRAS2	hsa-miR-23b-3p	93.1193	NM_001177314
RRAS2	hsa-miR-23a-3p	93.1193	NM_001177314
RRAS2	hsa-miR-548p	92.8091	NM_001177314
RRAS2	hsa-miR-4482-3p	92.1031	NM_001177314
RRAS2	hsa-miR-4697-3p	91.7091	NM_001102669
RRAS2	hsa-miR-4276	91.5665	NM_001102669
RRAS2	hsa-miR-548c-3p	91.0528	NM_001102669
RRAS2	hsa-miR-548s	90.9947	NM_001102669
RRAS2	hsa-miR-4424	90.5297	NM_001177314
RRAS2	hsa-miR-548at-5p	90.3725	NM_001102669
RRAS2	hsa-miR-4801	90.3235	NM_001177314
RRAS2	hsa-miR-4721	90.1453	NM_001102669
RRAS2	hsa-miR-193a-3p	89.5776	NM_001102669
RRAS2	hsa-miR-193b-3p	89.5776	NM_001102669
RRAS2	hsa-miR-1288-5p	89.5591	NM_001177314
RRAS2	hsa-miR-3190-5p	89.3894	NM_001102669
RRAS2	hsa-miR-4731-3p	89.2496	NM_001177314
RRAS2	hsa-miR-140-3p	88.9303	NM_001102669
RRAS2	hsa-miR-624-3p	88.0365	NM_001102669
RRAS2	hsa-miR-20a-5p	85.8735	NM_001102669
RRAS2	hsa-miR-106b-5p	85.8735	NM_001102669
RRAS2	hsa-miR-4529-5p	85.8182	NM_001102669
RRAS2	hsa-miR-656-3p	84.6852	NM_001102669
RRAS2	hsa-miR-4328	84.606	NM_001177314
RRAS2	hsa-miR-7974	84.3623	NM_001177314
RRAS2	hsa-miR-30a-5p	84.3281	NM_001102669
RRAS2	hsa-miR-30b-5p	84.3281	NM_001102669
RRAS2	hsa-miR-30e-5p	84.3281	NM_001102669
RRAS2	hsa-miR-30c-5p	84.3281	NM_001102669
RRAS2	hsa-miR-30d-5p	84.3281	NM_001102669
RRAS2	hsa-miR-203a-3p	83.4817	NM_001177314
RRAS2	hsa-miR-223-5p	83.315	NM_001177314
RRAS2	hsa-miR-548l	83.2897	NM_001102669
RRAS2	hsa-miR-935	83.1809	NM_001102669
RRAS2	hsa-miR-802	83.0949	NM_001177314
RRAS2	hsa-miR-6858-3p	82.9439	NM_001102669

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Motifs and transcription factors (TFs) regulating RRAS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RRAS2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RRAS2	metacluster_151.2	ZNF23 (directAnnotation).
RRAS2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RRAS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RRAS2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RRAS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RRAS2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RRAS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RRAS2	jaspar__MA0079.5	SP1 (directAnnotation).
RRAS2	transfac_pro__M04826	EP300 (directAnnotation).
RRAS2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RRAS2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RRAS2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RRAS2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RRAS2	transfac_pro__M00652	NRF1 (directAnnotation).
RRAS2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RRAS2	transfac_pro__M04866	HDAC2 (directAnnotation).
RRAS2	jaspar__MA1122.1	TFDP1 (directAnnotation).
RRAS2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RRAS2	metacluster_135.11	NR2C2 (directAnnotation).
RRAS2	tfdimers__MD00038	TFAP2C (directAnnotation).
RRAS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RRAS2	cisbp__M00968	MTF2 (directAnnotation).
RRAS2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RRAS2	metacluster_198.3	ZFP64 (directAnnotation).
RRAS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RRAS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RRAS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RRAS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RRAS2	cisbp__M00788	ZFY (inferredBy_Orthology).
RRAS2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RRAS2	metacluster_175.1	ZNF283 (directAnnotation).
RRAS2	hdpi__ZNF304	ZNF304 (directAnnotation).
RRAS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RRAS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RRAS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RRAS2	transfac_pro__M01199	TRIM28 (directAnnotation).
RRAS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RRAS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RRAS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
RRAS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."