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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RRAGD

Summary for RRAGD

Gene information	Gene symbol	RRAGD
	Ensembl ID	ENSG00000025039
	Entrez ID	58528
	Gene name	Ras related GTP binding D
	Synonyms	bA11D8.2.1\|DKFZP761H171
	Gene type	protein_coding
	UniProtAcc	Q9NQL2

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Dataset with differentially expressed gene: RRAGD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.77901	2.63e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.376552	2.22e-33
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.71182	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.388741	4.00e-16

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Expression of RRAGD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RRAGD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RRAGD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RRAGD	hsa-miR-106b-5p	98.8017	NM_021244
RRAGD	hsa-miR-20a-5p	98.8017	NM_021244
RRAGD	hsa-miR-106a-5p	98.768	NM_021244
RRAGD	hsa-miR-526b-3p	98.768	NM_021244
RRAGD	hsa-miR-519d-3p	98.6434	NM_021244
RRAGD	hsa-miR-17-5p	98.5779	NM_021244
RRAGD	hsa-miR-20b-5p	98.5779	NM_021244
RRAGD	hsa-miR-93-5p	98.5779	NM_021244
RRAGD	hsa-miR-6885-3p	98.4885	NM_021244
RRAGD	hsa-miR-520g-3p	98.2968	NM_021244
RRAGD	hsa-miR-520h	98.2968	NM_021244
RRAGD	hsa-miR-587	92.9824	NM_021244
RRAGD	hsa-miR-506-3p	92.732	NM_021244
RRAGD	hsa-miR-124-3p	92.732	NM_021244
RRAGD	hsa-miR-181a-2-3p	92.5419	NM_021244
RRAGD	hsa-miR-454-3p	91.8493	NM_021244
RRAGD	hsa-miR-300	90.9823	NM_021244
RRAGD	hsa-miR-381-3p	90.9823	NM_021244
RRAGD	hsa-miR-5590-5p	90.8138	NM_021244
RRAGD	hsa-miR-7152-3p	90.6139	NM_021244
RRAGD	hsa-miR-130b-3p	90.2798	NM_021244
RRAGD	hsa-miR-130a-3p	90.2798	NM_021244
RRAGD	hsa-miR-301b-3p	90.2798	NM_021244
RRAGD	hsa-miR-3666	90.2798	NM_021244
RRAGD	hsa-miR-301a-3p	90.2798	NM_021244
RRAGD	hsa-miR-4295	90.2798	NM_021244
RRAGD	hsa-miR-1283	89.7256	NM_021244
RRAGD	hsa-miR-3973	89.7133	NM_021244
RRAGD	hsa-miR-302e	89.1806	NM_021244
RRAGD	hsa-miR-302a-3p	88.9358	NM_021244
RRAGD	hsa-miR-373-3p	88.9358	NM_021244
RRAGD	hsa-miR-302c-3p	88.9358	NM_021244
RRAGD	hsa-miR-302b-3p	88.9358	NM_021244
RRAGD	hsa-miR-520e-3p	88.9358	NM_021244
RRAGD	hsa-miR-520b-3p	88.9358	NM_021244
RRAGD	hsa-miR-520c-3p	88.9358	NM_021244
RRAGD	hsa-miR-520a-3p	88.9358	NM_021244
RRAGD	hsa-miR-302d-3p	88.9358	NM_021244
RRAGD	hsa-miR-520d-3p	88.9358	NM_021244
RRAGD	hsa-miR-372-3p	88.9358	NM_021244
RRAGD	hsa-miR-4422	87.4241	NM_021244
RRAGD	hsa-miR-6772-3p	86.036	NM_021244
RRAGD	hsa-miR-3609	85.3849	NM_021244
RRAGD	hsa-miR-548ah-5p	85.3109	NM_021244
RRAGD	hsa-miR-548e-5p	85.2052	NM_021244
RRAGD	hsa-miR-411-3p	84.1025	NM_021244
RRAGD	hsa-miR-379-3p	84.1025	NM_021244
RRAGD	hsa-miR-7856-5p	84.0294	NM_021244
RRAGD	hsa-miR-559	83.7885	NM_021244
RRAGD	hsa-miR-9983-3p	83.3622	NM_021244

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Motifs and transcription factors (TFs) regulating RRAGD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RRAGD	metacluster_7.13	ZFX (directAnnotation).
RRAGD	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RRAGD	metacluster_151.2	ZNF23 (directAnnotation).
RRAGD	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RRAGD	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RRAGD	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RRAGD	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RRAGD	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
RRAGD	jaspar__MA0079.5	SP1 (directAnnotation).
RRAGD	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RRAGD	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RRAGD	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RRAGD	transfac_pro__M04617	ZBTB7A (directAnnotation).
RRAGD	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RRAGD	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RRAGD	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RRAGD	transfac_pro__M07387	ZBTB7A (directAnnotation).
RRAGD	transfac_pro__M07436	WT1 (directAnnotation).
RRAGD	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RRAGD	transfac_pro__M00716	ZBTB14 (directAnnotation).
RRAGD	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RRAGD	hdpi__HIP2	UBE2K (directAnnotation).
RRAGD	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RRAGD	transfac_pro__M04893	TAF1 (directAnnotation).
RRAGD	transfac_pro__M03876	ZBTB33 (directAnnotation).
RRAGD	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RRAGD	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RRAGD	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RRAGD	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RRAGD	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RRAGD	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RRAGD	metacluster_22.29	NFE2 (directAnnotation).
RRAGD	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RRAGD	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RRAGD	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
RRAGD	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."