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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RRAGC

Summary for RRAGC

Gene information	Gene symbol	RRAGC
	Ensembl ID	ENSG00000116954
	Entrez ID	64121
	Gene name	Ras related GTP binding C
	Synonyms	FLJ13311\|GTR2
	Gene type	protein_coding
	UniProtAcc	Q9HB90

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Dataset with differentially expressed gene: RRAGC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.307306	0.00e+00

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Expression of RRAGC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RRAGC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RRAGC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RRAGC	hsa-miR-5693	98.3097	NM_001271851
RRAGC	hsa-miR-3152-3p	93.9456	NM_001271851
RRAGC	hsa-miR-4276	92.7329	NM_001271851
RRAGC	hsa-miR-144-5p	92.4396	NM_022157
RRAGC	hsa-miR-627-3p	91.9224	NM_022157
RRAGC	hsa-miR-5190	91.1235	NM_001271851
RRAGC	hsa-miR-660-5p	90.3421	NM_022157
RRAGC	hsa-miR-34c-5p	88.4946	NM_001271851
RRAGC	hsa-miR-449b-5p	88.4946	NM_001271851
RRAGC	hsa-miR-449a	88.4946	NM_001271851
RRAGC	hsa-miR-34a-5p	88.4946	NM_001271851
RRAGC	hsa-miR-6875-3p	88.1291	NM_022157
RRAGC	hsa-miR-4729	86.4547	NM_022157
RRAGC	hsa-miR-3691-3p	85.6958	NM_001271851
RRAGC	hsa-miR-6499-3p	85.0278	NM_001271851
RRAGC	hsa-miR-4482-3p	84.412	NM_022157
RRAGC	hsa-miR-1305	84.1468	NM_022157
RRAGC	hsa-miR-888-5p	83.5801	NM_022157
RRAGC	hsa-miR-9900	83.3816	NM_001271851
RRAGC	hsa-miR-4708-3p	83.2124	NM_001271851
RRAGC	hsa-miR-4490	83.1045	NM_001271851
RRAGC	hsa-miR-5687	82.4087	NM_001271851
RRAGC	hsa-miR-6505-5p	81.125	NM_022157
RRAGC	hsa-miR-4774-5p	80.886	NM_001271851
RRAGC	hsa-miR-4495	80.692	NM_001271851
RRAGC	hsa-miR-5700	80.562	NM_022157
RRAGC	hsa-miR-548e-5p	80.5217	NM_022157
RRAGC	hsa-miR-103a-3p	80.2541	NM_022157
RRAGC	hsa-miR-107	80.2541	NM_022157

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Motifs and transcription factors (TFs) regulating RRAGC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RRAGC	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RRAGC	transfac_pro__M05479	ZNF580 (directAnnotation).
RRAGC	jaspar__MA0079.5	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."