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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPS6KB1

Summary for RPS6KB1

Gene information	Gene symbol	RPS6KB1
	Ensembl ID	ENSG00000108443
	Entrez ID	6198
	Gene name	ribosomal protein S6 kinase B1
	Synonyms	p70(S6K)-alpha\|PS6K\|S6K\|S6K1\|STK14A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RPS6KB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.265328	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.393265	2.47e-32

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Expression of RPS6KB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPS6KB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RPS6KB1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RPS6KB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPS6KB1	hsa-miR-4774-3p	98.9018	NM_001272042
RPS6KB1	hsa-miR-4668-3p	98.428	NM_001272042
RPS6KB1	hsa-miR-3714	98.3957	NM_001272042
RPS6KB1	hsa-miR-429	98.2762	NM_001272042
RPS6KB1	hsa-miR-200b-3p	98.2762	NM_001272042
RPS6KB1	hsa-miR-200c-3p	98.2762	NM_001272042
RPS6KB1	hsa-miR-9983-3p	98.1738	NM_001272042
RPS6KB1	hsa-miR-6885-3p	98.0375	NM_001272042
RPS6KB1	hsa-miR-129-5p	97.222	NM_001272042
RPS6KB1	hsa-miR-8084	97.1732	NM_001272042
RPS6KB1	hsa-miR-3148	96.9946	NM_001272042
RPS6KB1	hsa-miR-3152-5p	96.982	NM_001272042
RPS6KB1	hsa-miR-3613-3p	96.5466	NM_001272042
RPS6KB1	hsa-miR-3064-3p	95.6031	NM_001272042
RPS6KB1	hsa-miR-4504	95.4996	NM_001272042
RPS6KB1	hsa-miR-3163	95.4491	NM_001272042
RPS6KB1	hsa-miR-3914	94.9132	NM_001272043
RPS6KB1	hsa-miR-186-5p	94.3561	NM_001272043
RPS6KB1	hsa-miR-6504-3p	93.6694	NM_001272042
RPS6KB1	hsa-miR-10399-5p	93.6694	NM_001272042
RPS6KB1	hsa-miR-507	93.5551	NM_001272042
RPS6KB1	hsa-miR-4262	93.4922	NM_001272043
RPS6KB1	hsa-miR-335-3p	93.3893	NM_001272042
RPS6KB1	hsa-miR-3915	93.0642	NM_001272043
RPS6KB1	hsa-miR-377-3p	92.9703	NM_001272042
RPS6KB1	hsa-miR-548ar-3p	92.6627	NM_001272043
RPS6KB1	hsa-miR-6728-5p	92.627	NM_001272042
RPS6KB1	hsa-miR-3658	92.5492	NM_001272043
RPS6KB1	hsa-miR-27b-3p	92.5274	NM_001272042
RPS6KB1	hsa-miR-27a-3p	92.5274	NM_001272042
RPS6KB1	hsa-miR-9985	92.5274	NM_001272042
RPS6KB1	hsa-miR-6513-5p	92.5084	NM_001272042
RPS6KB1	hsa-miR-551b-5p	92.2938	NM_001272042
RPS6KB1	hsa-miR-6740-5p	92.272	NM_001272042
RPS6KB1	hsa-miR-4743-3p	92.1067	NM_001272042
RPS6KB1	hsa-miR-548bc	92.0846	NM_001272043
RPS6KB1	hsa-miR-548f-3p	92.0846	NM_001272043
RPS6KB1	hsa-miR-548az-3p	92.0846	NM_001272043
RPS6KB1	hsa-miR-548e-3p	92.0846	NM_001272043
RPS6KB1	hsa-miR-548a-3p	92.0846	NM_001272043
RPS6KB1	hsa-miR-8062	92.078	NM_001272042
RPS6KB1	hsa-miR-1537-5p	92.0478	NM_001272043
RPS6KB1	hsa-miR-557	91.8706	NM_001272042
RPS6KB1	hsa-miR-1277-5p	91.4038	NM_001272042
RPS6KB1	hsa-miR-153-5p	91.3305	NM_001272042
RPS6KB1	hsa-miR-1226-3p	90.7423	NM_001272043
RPS6KB1	hsa-miR-362-5p	90.6776	NM_001272042
RPS6KB1	hsa-miR-500b-5p	90.6776	NM_001272042
RPS6KB1	hsa-miR-5680	90.5275	NM_001272042
RPS6KB1	hsa-miR-3680-3p	90.1067	NM_001272042

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Motifs and transcription factors (TFs) regulating RPS6KB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPS6KB1	metacluster_135.11	NR2C2 (directAnnotation).
RPS6KB1	metacluster_7.13	ZFX (directAnnotation).
RPS6KB1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RPS6KB1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RPS6KB1	metacluster_198.3	ZFP64 (directAnnotation).
RPS6KB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RPS6KB1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RPS6KB1	cisbp__M00788	ZFY (inferredBy_Orthology).
RPS6KB1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RPS6KB1	metacluster_175.1	ZNF283 (directAnnotation).
RPS6KB1	hdpi__ZNF304	ZNF304 (directAnnotation).
RPS6KB1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RPS6KB1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RPS6KB1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RPS6KB1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RPS6KB1	metacluster_151.2	ZNF23 (directAnnotation).
RPS6KB1	transfac_pro__M03806	ZBTB7C (directAnnotation).
RPS6KB1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RPS6KB1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RPS6KB1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RPS6KB1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RPS6KB1	transfac_pro__M04893	TAF1 (directAnnotation).
RPS6KB1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
RPS6KB1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
RPS6KB1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RPS6KB1	transfac_pro__M00938	E2F1 (directAnnotation).
RPS6KB1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
RPS6KB1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
RPS6KB1	hdpi__RARA	RARA (directAnnotation).
RPS6KB1	transfac_pro__M02898	SMAD3 (directAnnotation).
RPS6KB1	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."