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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPS6KA5

Summary for RPS6KA5

Gene information	Gene symbol	RPS6KA5
	Ensembl ID	ENSG00000100784
	Entrez ID	9252
	Gene name	ribosomal protein S6 kinase A5
	Synonyms	MSK1\|RLPK
	Gene type	protein_coding
	UniProtAcc	O75582

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Dataset with differentially expressed gene: RPS6KA5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.57321	0.00e+00

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Expression of RPS6KA5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPS6KA5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RPS6KA5	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RPS6KA5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPS6KA5	hsa-miR-340-5p	99.7664	NM_001322227
RPS6KA5	hsa-miR-4499	99.6237	NM_182398
RPS6KA5	hsa-miR-3163	99.603	NM_001322227
RPS6KA5	hsa-miR-216a-3p	99.5858	NM_001322227
RPS6KA5	hsa-miR-128-3p	99.472	NM_001322227
RPS6KA5	hsa-miR-130a-3p	99.454	NM_001322227
RPS6KA5	hsa-miR-454-3p	99.4276	NM_001322227
RPS6KA5	hsa-miR-19b-3p	99.2862	NM_001322227
RPS6KA5	hsa-miR-19a-3p	99.2862	NM_001322227
RPS6KA5	hsa-miR-3666	99.2776	NM_001322227
RPS6KA5	hsa-miR-130b-3p	99.2776	NM_001322227
RPS6KA5	hsa-miR-301a-3p	99.2776	NM_001322227
RPS6KA5	hsa-miR-301b-3p	99.2776	NM_001322227
RPS6KA5	hsa-miR-4295	99.2776	NM_001322227
RPS6KA5	hsa-miR-3681-3p	99.2736	NM_001322227
RPS6KA5	hsa-miR-152-3p	99.2126	NM_001322227
RPS6KA5	hsa-miR-148b-3p	99.2126	NM_001322227
RPS6KA5	hsa-miR-148a-3p	99.2126	NM_001322227
RPS6KA5	hsa-miR-27b-3p	98.6682	NM_001322227
RPS6KA5	hsa-miR-9985	98.6682	NM_001322227
RPS6KA5	hsa-miR-27a-3p	98.6682	NM_001322227
RPS6KA5	hsa-miR-5590-3p	98.4702	NM_001322227
RPS6KA5	hsa-miR-142-5p	98.2788	NM_001322227
RPS6KA5	hsa-miR-20a-5p	98.093	NM_001322227
RPS6KA5	hsa-miR-106b-5p	98.093	NM_001322227
RPS6KA5	hsa-miR-4282	97.5879	NM_001322227
RPS6KA5	hsa-miR-93-5p	97.1249	NM_001322227
RPS6KA5	hsa-miR-526b-3p	97.1249	NM_001322227
RPS6KA5	hsa-miR-106a-5p	97.1249	NM_001322227
RPS6KA5	hsa-miR-20b-5p	97.1249	NM_001322227
RPS6KA5	hsa-miR-17-5p	97.1249	NM_001322227
RPS6KA5	hsa-miR-519d-3p	97.1249	NM_001322227
RPS6KA5	hsa-miR-9983-3p	96.9331	NM_001322233
RPS6KA5	hsa-miR-129-5p	95.623	NM_001322233
RPS6KA5	hsa-miR-211-5p	94.932	NM_001322227
RPS6KA5	hsa-miR-204-5p	94.932	NM_001322227
RPS6KA5	hsa-miR-151a-3p	94.8389	NM_182398
RPS6KA5	hsa-miR-4782-5p	94.3317	NM_001322233
RPS6KA5	hsa-miR-5706	94.3317	NM_001322233
RPS6KA5	hsa-miR-587	93.9051	NM_182398
RPS6KA5	hsa-miR-153-3p	93.4201	NM_001322227
RPS6KA5	hsa-miR-4495	93.061	NM_182398
RPS6KA5	hsa-miR-519c-3p	92.886	NM_001322227
RPS6KA5	hsa-miR-519b-3p	92.886	NM_001322227
RPS6KA5	hsa-miR-519a-3p	92.886	NM_001322227
RPS6KA5	hsa-miR-3194-3p	92.6401	NM_001322233
RPS6KA5	hsa-miR-1-5p	92.4966	NM_001322233
RPS6KA5	hsa-miR-4446-5p	92.1944	NM_001322227
RPS6KA5	hsa-miR-5006-3p	91.7588	NM_001322227
RPS6KA5	hsa-miR-4755-5p	91.7588	NM_001322227

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Motifs and transcription factors (TFs) regulating RPS6KA5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPS6KA5	metacluster_7.13	ZFX (directAnnotation).
RPS6KA5	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
RPS6KA5	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
RPS6KA5	metacluster_151.2	ZNF23 (directAnnotation).
RPS6KA5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RPS6KA5	transfac_pro__M05479	ZNF580 (directAnnotation).
RPS6KA5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RPS6KA5	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RPS6KA5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RPS6KA5	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RPS6KA5	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RPS6KA5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RPS6KA5	jaspar__MA0079.5	SP1 (directAnnotation).
RPS6KA5	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
RPS6KA5	transfac_pro__M04826	EP300 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."