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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RPS6KA3

Summary for RPS6KA3

Gene information	Gene symbol	RPS6KA3
	Ensembl ID	ENSG00000177189
	Entrez ID	6197
	Gene name	ribosomal protein S6 kinase A3
	Synonyms	CLS\|HU-3\|MRX19\|RSK2
	Gene type	protein_coding
	UniProtAcc	P51812

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Dataset with differentially expressed gene: RPS6KA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.286557	2.18e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.293644	7.54e-14

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Expression of RPS6KA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPS6KA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RPS6KA3	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RPS6KA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPS6KA3	hsa-miR-548x-3p	99.246	NM_004586
RPS6KA3	hsa-miR-548aj-3p	99.246	NM_004586
RPS6KA3	hsa-miR-548aq-3p	99.0081	NM_004586
RPS6KA3	hsa-miR-548ah-3p	99.0081	NM_004586
RPS6KA3	hsa-miR-548j-3p	99.0081	NM_004586
RPS6KA3	hsa-miR-548am-3p	99.0081	NM_004586
RPS6KA3	hsa-miR-548ae-3p	99.0081	NM_004586
RPS6KA3	hsa-miR-4276	98.5396	NM_004586
RPS6KA3	hsa-miR-5688	98.3175	NM_004586
RPS6KA3	hsa-miR-510-3p	98.2608	NM_004586
RPS6KA3	hsa-miR-495-3p	97.9913	NM_004586
RPS6KA3	hsa-miR-3163	97.7646	NM_004586
RPS6KA3	hsa-miR-633	97.6708	NM_004586
RPS6KA3	hsa-miR-223-5p	96.7345	NM_004586
RPS6KA3	hsa-miR-5696	96.166	NM_004586
RPS6KA3	hsa-miR-337-3p	94.9719	NM_004586
RPS6KA3	hsa-miR-155-5p	94.4585	NM_004586
RPS6KA3	hsa-miR-12123	94.2473	NM_004586
RPS6KA3	hsa-miR-6507-5p	94.1335	NM_004586
RPS6KA3	hsa-miR-183-5p	93.5436	NM_004586
RPS6KA3	hsa-miR-16-5p	93.2562	NM_004586
RPS6KA3	hsa-miR-195-5p	93.2562	NM_004586
RPS6KA3	hsa-miR-15a-5p	93.2562	NM_004586
RPS6KA3	hsa-miR-6838-5p	93.2562	NM_004586
RPS6KA3	hsa-miR-15b-5p	93.2562	NM_004586
RPS6KA3	hsa-miR-497-5p	91.8564	NM_004586
RPS6KA3	hsa-miR-424-5p	91.8564	NM_004586
RPS6KA3	hsa-miR-4262	91.2593	NM_004586
RPS6KA3	hsa-miR-3938	91.0943	NM_004586
RPS6KA3	hsa-miR-186-5p	90.9459	NM_004586
RPS6KA3	hsa-miR-1263	90.88	NM_004586
RPS6KA3	hsa-miR-579-3p	90.8398	NM_004586
RPS6KA3	hsa-miR-4796-3p	90.5235	NM_004586
RPS6KA3	hsa-miR-181b-5p	90.4171	NM_004586
RPS6KA3	hsa-miR-181a-5p	90.4171	NM_004586
RPS6KA3	hsa-miR-6853-3p	90.25	NM_004586
RPS6KA3	hsa-miR-664b-3p	89.9361	NM_004586
RPS6KA3	hsa-miR-4302	89.764	NM_004586
RPS6KA3	hsa-miR-6733-3p	89.4391	NM_004586
RPS6KA3	hsa-miR-181d-5p	88.8514	NM_004586
RPS6KA3	hsa-miR-181c-5p	88.8514	NM_004586
RPS6KA3	hsa-miR-636	88.6145	NM_004586
RPS6KA3	hsa-miR-3148	88.378	NM_004586
RPS6KA3	hsa-miR-7-2-3p	88.2615	NM_004586
RPS6KA3	hsa-miR-7-1-3p	88.2615	NM_004586
RPS6KA3	hsa-miR-4698	88.2275	NM_004586
RPS6KA3	hsa-miR-4475	87.655	NM_004586
RPS6KA3	hsa-miR-335-3p	87.5783	NM_004586
RPS6KA3	hsa-miR-367-5p	87.0386	NM_004586
RPS6KA3	hsa-miR-494-3p	86.7551	NM_004586

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Motifs and transcription factors (TFs) regulating RPS6KA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPS6KA3	metacluster_135.11	NR2C2 (directAnnotation).
RPS6KA3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RPS6KA3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RPS6KA3	metacluster_7.13	ZFX (directAnnotation).
RPS6KA3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RPS6KA3	cisbp__M00968	MTF2 (directAnnotation).
RPS6KA3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RPS6KA3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RPS6KA3	cisbp__M00341	PAX6 (directAnnotation).
RPS6KA3	metacluster_198.3	ZFP64 (directAnnotation).
RPS6KA3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RPS6KA3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RPS6KA3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RPS6KA3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RPS6KA3	cisbp__M00788	ZFY (inferredBy_Orthology).
RPS6KA3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RPS6KA3	metacluster_175.1	ZNF283 (directAnnotation).
RPS6KA3	hdpi__ZNF304	ZNF304 (directAnnotation).
RPS6KA3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RPS6KA3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RPS6KA3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RPS6KA3	transfac_pro__M01199	TRIM28 (directAnnotation).
RPS6KA3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RPS6KA3	metacluster_151.2	ZNF23 (directAnnotation).
RPS6KA3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RPS6KA3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RPS6KA3	transfac_pro__M03806	ZBTB7C (directAnnotation).
RPS6KA3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RPS6KA3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RPS6KA3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RPS6KA3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RPS6KA3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RPS6KA3	transfac_pro__M04826	EP300 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RPS6KA3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RPS6KA3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RPS6KA3	jaspar__MA1708.1	ETV7 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RPS6KA3	hdpi__TP73	TP73 (directAnnotation).
RPS6KA3	hdpi__ELF2	ELF2 (directAnnotation).
RPS6KA3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
RPS6KA3	metacluster_183.4	ETS1 (inferredBy_Orthology).
RPS6KA3	metacluster_81.7	CREB1 (directAnnotation).
RPS6KA3	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RPS6KA3	"Acetylsalicylic acid"	DB00945	small molecule
RPS6KA3	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."