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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPRD2

Summary for RPRD2

Gene information	Gene symbol	RPRD2
	Ensembl ID	ENSG00000163125
	Entrez ID	23248
	Gene name	regulation of nuclear pre-mRNA domain containing 2
	Synonyms	FLJ32145\|HSPC099\|KIAA0460
	Gene type	protein_coding
	UniProtAcc	Q5VT52

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Dataset with differentially expressed gene: RPRD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.309644	9.65e-20
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.350265	0.00e+00

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Expression of RPRD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPRD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RPRD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPRD2	hsa-miR-23a-3p	97.875	NM_001297673
RPRD2	hsa-miR-23c	97.875	NM_001297673
RPRD2	hsa-miR-23b-3p	97.875	NM_001297673
RPRD2	hsa-miR-4779	94.4851	NM_001297673
RPRD2	hsa-miR-5006-3p	93.6279	NM_001297673
RPRD2	hsa-miR-3160-5p	93.0012	NM_015203
RPRD2	hsa-miR-485-5p	92.5052	NM_015203
RPRD2	hsa-miR-6884-5p	92.5052	NM_015203
RPRD2	hsa-miR-4755-5p	92.2299	NM_001297673
RPRD2	hsa-miR-6715a-3p	91.4206	NM_001297673
RPRD2	hsa-miR-519a-3p	90.8275	NM_015203
RPRD2	hsa-miR-519c-3p	90.8275	NM_015203
RPRD2	hsa-miR-519b-3p	90.8275	NM_015203
RPRD2	hsa-miR-4728-5p	89.4538	NM_001297673
RPRD2	hsa-miR-6785-5p	89.4538	NM_001297673
RPRD2	hsa-miR-6727-3p	88.5328	NM_001297673
RPRD2	hsa-miR-765	87.6329	NM_001297673
RPRD2	hsa-miR-196a-1-3p	87.5347	NM_015203
RPRD2	hsa-miR-6887-3p	87.5306	NM_015203
RPRD2	hsa-miR-374b-5p	86.8829	NM_015203
RPRD2	hsa-miR-130b-5p	86.264	NM_001297673
RPRD2	hsa-miR-6881-5p	86.1211	NM_015203
RPRD2	hsa-miR-374a-5p	85.9748	NM_015203
RPRD2	hsa-miR-520a-5p	85.8909	NM_001297673
RPRD2	hsa-miR-525-5p	85.8909	NM_001297673
RPRD2	hsa-miR-11181-3p	85.8413	NM_001297673
RPRD2	hsa-miR-4722-3p	85.17	NM_001297673
RPRD2	hsa-miR-149-3p	84.283	NM_001297673
RPRD2	hsa-miR-6883-5p	84.283	NM_001297673
RPRD2	hsa-miR-6884-3p	83.7744	NM_001297673
RPRD2	hsa-miR-2117	83.1549	NM_001297673
RPRD2	hsa-miR-5692c	82.982	NM_015203
RPRD2	hsa-miR-5692b	82.982	NM_015203
RPRD2	hsa-miR-4738-3p	82.9805	NM_001297673
RPRD2	hsa-miR-516a-5p	82.83	NM_001297673
RPRD2	hsa-miR-552-5p	82.3923	NM_015203
RPRD2	hsa-miR-4782-3p	82.0274	NM_001297673
RPRD2	hsa-miR-219a-5p	82.0274	NM_001297673
RPRD2	hsa-miR-6766-3p	82.0274	NM_001297673
RPRD2	hsa-miR-3151-5p	81.1523	NM_001297673
RPRD2	hsa-miR-711	80.2863	NM_001297673
RPRD2	hsa-miR-570-3p	80.1757	NM_001297673

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Motifs and transcription factors (TFs) regulating RPRD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPRD2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RPRD2	transfac_pro__M04950	EGR1 (directAnnotation).
RPRD2	metacluster_55.5	ZNF541 (directAnnotation).
RPRD2	transfac_pro__M04913	ZBTB7A (directAnnotation).
RPRD2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."