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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPP30

Summary for RPP30

Gene information	Gene symbol	RPP30
	Ensembl ID	ENSG00000148688
	Entrez ID	10556
	Gene name	ribonuclease P/MRP subunit p30
	Synonyms	TSG15
	Gene type	protein_coding
	UniProtAcc	P78346

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Dataset with differentially expressed gene: RPP30

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.265174	1.03e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.447875	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.364993	3.60e-21
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.339504	3.39e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.342441	1.28e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.33338	7.91e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.302994	0.00e+00

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Expression of RPP30 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPP30

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RPP30

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPP30	hsa-miR-548ar-3p	95.2154	NM_006413
RPP30	hsa-miR-373-5p	95.1385	NM_006413
RPP30	hsa-miR-616-5p	95.1385	NM_006413
RPP30	hsa-miR-371b-5p	95.1385	NM_006413
RPP30	hsa-miR-3115	94.5929	NM_001104546
RPP30	hsa-miR-16-2-3p	94.0697	NM_006413
RPP30	hsa-miR-195-3p	94.0697	NM_006413
RPP30	hsa-miR-3654	93.935	NM_001104546
RPP30	hsa-miR-10395-3p	93.1047	NM_006413
RPP30	hsa-miR-548bc	92.1114	NM_006413
RPP30	hsa-miR-548az-3p	92.1114	NM_006413
RPP30	hsa-miR-548f-3p	92.1114	NM_006413
RPP30	hsa-miR-548e-3p	92.1114	NM_006413
RPP30	hsa-miR-548a-3p	92.1114	NM_006413
RPP30	hsa-miR-10523-5p	90.3861	NM_001104546
RPP30	hsa-miR-3679-3p	90.2347	NM_001104546
RPP30	hsa-miR-4668-5p	89.9909	NM_006413
RPP30	hsa-miR-4753-3p	89.5314	NM_006413
RPP30	hsa-miR-4768-5p	89.1222	NM_006413
RPP30	hsa-miR-5584-5p	88.938	NM_006413
RPP30	hsa-miR-6873-3p	88.8493	NM_006413
RPP30	hsa-miR-7159-3p	87.5729	NM_001104546
RPP30	hsa-miR-6833-3p	87.0029	NM_006413
RPP30	hsa-miR-676-5p	87.0007	NM_001104546
RPP30	hsa-miR-489-3p	86.1957	NM_001104546
RPP30	hsa-miR-4710	85.9088	NM_006413
RPP30	hsa-miR-503-3p	85.7841	NM_001104546
RPP30	hsa-miR-6852-3p	85.6783	NM_001104546
RPP30	hsa-miR-3913-3p	85.5378	NM_001104546
RPP30	hsa-miR-9851-3p	85.5099	NM_001104546
RPP30	hsa-miR-606	82.9196	NM_006413
RPP30	hsa-miR-33a-3p	82.052	NM_006413
RPP30	hsa-miR-664a-3p	82.0486	NM_006413
RPP30	hsa-miR-143-3p	81.94	NM_001104546
RPP30	hsa-miR-6088	81.94	NM_001104546
RPP30	hsa-miR-4770	81.94	NM_001104546
RPP30	hsa-miR-3613-3p	81.4235	NM_006413
RPP30	hsa-miR-593-5p	80.8042	NM_001104546
RPP30	hsa-miR-23c	80.438	NM_001104546
RPP30	hsa-miR-23a-3p	80.438	NM_001104546
RPP30	hsa-miR-23b-3p	80.438	NM_001104546
RPP30	hsa-miR-1827	80.3081	NM_001104546
RPP30	hsa-miR-10522-5p	80.2272	NM_001104546

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Motifs and transcription factors (TFs) regulating RPP30

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPP30	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RPP30	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RPP30	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
RPP30	cisbp__M00808	MYPOP (inferredBy_Orthology).
RPP30	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RPP30	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
RPP30	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RPP30	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RPP30	transfac_pro__M00652	NRF1 (directAnnotation).
RPP30	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RPP30	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
RPP30	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RPP30	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
RPP30	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
RPP30	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RPP30	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."