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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPP14

Summary for RPP14

Gene information	Gene symbol	RPP14
	Ensembl ID	ENSG00000163684
	Entrez ID	11102
	Gene name	ribonuclease P/MRP subunit p14
	Synonyms	P14
	Gene type	protein_coding
	UniProtAcc	O95059

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Dataset with differentially expressed gene: RPP14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.287301	1.04e-29
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.318899	0.00e+00

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Expression of RPP14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPP14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RPP14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPP14	hsa-miR-519d-5p	99.4102	NM_001098783
RPP14	hsa-miR-5695	99.4102	NM_001098783
RPP14	hsa-miR-515-5p	98.0017	NM_001098783
RPP14	hsa-miR-519e-5p	98.0017	NM_001098783
RPP14	hsa-miR-4430	95.029	NM_001098783
RPP14	hsa-miR-3652	95.029	NM_001098783
RPP14	hsa-miR-4297	94.5731	NM_001098783
RPP14	hsa-miR-6783-3p	94.3082	NM_001098783
RPP14	hsa-miR-5581-5p	94.004	NM_001098783
RPP14	hsa-miR-1343-3p	93.9887	NM_001098783
RPP14	hsa-miR-6722-3p	91.7731	NM_001098783
RPP14	hsa-miR-105-5p	91.625	NM_001098783
RPP14	hsa-miR-7853-5p	91.625	NM_001098783
RPP14	hsa-miR-132-3p	91.329	NM_001098783
RPP14	hsa-miR-212-3p	91.329	NM_001098783
RPP14	hsa-miR-4482-3p	91.1334	NM_001098783
RPP14	hsa-miR-6733-5p	90.7568	NM_001098783
RPP14	hsa-miR-6739-5p	90.7568	NM_001098783
RPP14	hsa-miR-19b-1-5p	90.7143	NM_001098783
RPP14	hsa-miR-19b-2-5p	90.7143	NM_001098783
RPP14	hsa-miR-19a-5p	90.7143	NM_001098783
RPP14	hsa-miR-345-3p	89.8874	NM_001098783
RPP14	hsa-miR-3158-5p	89.5424	NM_001098783
RPP14	hsa-miR-6842-5p	88.4615	NM_001098783
RPP14	hsa-miR-7110-5p	88.4615	NM_001098783
RPP14	hsa-miR-527	88.2585	NM_001098783
RPP14	hsa-miR-518a-5p	88.2585	NM_001098783
RPP14	hsa-miR-9851-3p	88.168	NM_001098783
RPP14	hsa-miR-593-5p	88.168	NM_001098783
RPP14	hsa-miR-3153	88.0686	NM_001098783
RPP14	hsa-miR-450b-5p	87.7574	NM_001098783
RPP14	hsa-miR-3157-5p	87.7355	NM_001098783
RPP14	hsa-miR-6752-5p	86.9165	NM_001098783
RPP14	hsa-miR-4261	86.7441	NM_001098783
RPP14	hsa-miR-3149	84.8677	NM_001098783
RPP14	hsa-miR-622	84.1511	NM_001098783
RPP14	hsa-miR-1909-3p	82.7078	NM_001098783
RPP14	hsa-miR-6770-5p	82.4065	NM_001098783
RPP14	hsa-miR-6842-3p	82.052	NM_001098783
RPP14	hsa-miR-221-5p	81.9485	NM_001098783
RPP14	hsa-miR-8073	81.9485	NM_001098783
RPP14	hsa-miR-4681	80.4789	NM_001098783
RPP14	hsa-miR-205-3p	80.4726	NM_001098783

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Motifs and transcription factors (TFs) regulating RPP14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPP14	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RPP14	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."