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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPGR

Summary for RPGR

Gene information	Gene symbol	RPGR
	Ensembl ID	ENSG00000156313
	Entrez ID	6103
	Gene name	retinitis pigmentosa GTPase regulator
	Synonyms	COD1\|CORDX1\|CRD\|RP15\|RP3
	Gene type	protein_coding
	UniProtAcc	Q92834

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Dataset with differentially expressed gene: RPGR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.304377	5.75e-23
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.305999	1.99e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.319535	2.25e-18

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Expression of RPGR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPGR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RPGR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPGR	hsa-miR-4789-3p	98.503	NM_001034853
RPGR	hsa-miR-216b-3p	96.618	NM_000328
RPGR	hsa-miR-1226-5p	96.3541	NM_001034853
RPGR	hsa-miR-6853-3p	95.9994	NM_000328
RPGR	hsa-miR-6889-3p	95.9093	NM_001034853
RPGR	hsa-miR-6529-3p	95.4161	NM_001034853
RPGR	hsa-miR-4775	94.1542	NM_001034853
RPGR	hsa-miR-5093	93.9014	NM_001034853
RPGR	hsa-miR-4708-3p	93.4812	NM_001034853
RPGR	hsa-miR-1297	92.7588	NM_000328
RPGR	hsa-miR-340-5p	92.6075	NM_000328
RPGR	hsa-miR-10399-5p	92.4653	NM_001034853
RPGR	hsa-miR-6504-3p	92.4653	NM_001034853
RPGR	hsa-miR-6760-5p	91.7639	NM_000328
RPGR	hsa-miR-26b-5p	91.4684	NM_000328
RPGR	hsa-miR-26a-5p	91.4684	NM_000328
RPGR	hsa-miR-4677-3p	89.3324	NM_001034853
RPGR	hsa-miR-4465	89.2063	NM_000328
RPGR	hsa-miR-760	89.1224	NM_001034853
RPGR	hsa-miR-5008-5p	88.1677	NM_001034853
RPGR	hsa-miR-8054	86.3357	NM_001034853
RPGR	hsa-miR-548k	86.3357	NM_001034853
RPGR	hsa-miR-548av-5p	86.3357	NM_001034853
RPGR	hsa-miR-4724-5p	85.8897	NM_000328
RPGR	hsa-miR-6829-3p	84.5005	NM_001034853
RPGR	hsa-miR-6791-3p	84.5005	NM_001034853
RPGR	hsa-miR-4777-3p	84.4647	NM_000328
RPGR	hsa-miR-590-3p	84.154	NM_001034853
RPGR	hsa-miR-3163	84.1412	NM_000328
RPGR	hsa-miR-3133	83.0169	NM_001034853
RPGR	hsa-miR-570-3p	82.9827	NM_000328
RPGR	hsa-miR-4538	81.6453	NM_001034853
RPGR	hsa-miR-4453	81.6453	NM_001034853
RPGR	hsa-miR-1264	81.0599	NM_000328
RPGR	hsa-miR-3162-5p	80.8655	NM_000328
RPGR	hsa-miR-3692-3p	80.0212	NM_000328

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Motifs and transcription factors (TFs) regulating RPGR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPGR	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RPGR	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RPGR	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RPGR	transfac_pro__M04826	EP300 (directAnnotation).
RPGR	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RPGR	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RPGR	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
RPGR	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RPGR	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RPGR	hdpi__TP73	TP73 (directAnnotation).
RPGR	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RPGR	cisbp__M02645	ETS1 (directAnnotation).
RPGR	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RPGR	jaspar__MA1708.1	ETV7 (directAnnotation).
RPGR	cisbp__M08198	ELF1 (directAnnotation).
RPGR	hdpi__ELF2	ELF2 (directAnnotation).
RPGR	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RPGR	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
RPGR	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RPGR	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
RPGR	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
RPGR	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
RPGR	jaspar__MA1932.1	HOXB13 (directAnnotation).
RPGR	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RPGR	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
RPGR	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."