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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ROBO2

Summary for ROBO2

Gene information	Gene symbol	ROBO2
	Ensembl ID	ENSG00000185008
	Entrez ID	6092
	Gene name	roundabout guidance receptor 2
	Synonyms	KIAA1568
	Gene type	protein_coding
	UniProtAcc	Q9HCK4

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Dataset with differentially expressed gene: ROBO2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.333433	0.00e+00

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Expression of ROBO2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ROBO2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ROBO2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ROBO2	hsa-miR-9851-3p	98.5899	NM_001128929
ROBO2	hsa-miR-12136	98.3575	NM_001128929
ROBO2	hsa-miR-23c	97.864	NM_001128929
ROBO2	hsa-miR-23b-3p	97.864	NM_001128929
ROBO2	hsa-miR-23a-3p	97.864	NM_001128929
ROBO2	hsa-miR-582-5p	97.8613	NM_001128929
ROBO2	hsa-miR-570-3p	97.6206	NM_001128929
ROBO2	hsa-miR-593-5p	97.4483	NM_001128929
ROBO2	hsa-miR-8066	97.3072	NM_001128929
ROBO2	hsa-miR-134-3p	96.8288	NM_001128929
ROBO2	hsa-miR-5585-3p	96.3252	NM_001128929
ROBO2	hsa-miR-1912-5p	96.2077	NM_001128929
ROBO2	hsa-miR-6853-3p	95.8804	NM_001128929
ROBO2	hsa-miR-4275	94.9113	NM_001128929
ROBO2	hsa-miR-548g-3p	94.7142	NM_001128929
ROBO2	hsa-miR-3163	94.584	NM_001128929
ROBO2	hsa-miR-4801	94.3762	NM_001128929
ROBO2	hsa-miR-633	94.0733	NM_001128929
ROBO2	hsa-miR-4503	93.9218	NM_001128929
ROBO2	hsa-miR-148a-3p	93.8673	NM_001128929
ROBO2	hsa-miR-148b-3p	93.8673	NM_001128929
ROBO2	hsa-miR-152-3p	93.8673	NM_001128929
ROBO2	hsa-miR-19a-3p	93.8523	NM_001128929
ROBO2	hsa-miR-19b-3p	93.8523	NM_001128929
ROBO2	hsa-miR-4317	93.7123	NM_001128929
ROBO2	hsa-miR-3973	93.5229	NM_001128929
ROBO2	hsa-miR-10527-5p	93.174	NM_001128929
ROBO2	hsa-miR-1185-2-3p	93.1543	NM_001128929
ROBO2	hsa-let-7f-2-3p	93.1543	NM_001128929
ROBO2	hsa-miR-1185-1-3p	93.1543	NM_001128929
ROBO2	hsa-miR-92a-3p	92.7449	NM_001128929
ROBO2	hsa-miR-32-5p	92.7449	NM_001128929
ROBO2	hsa-miR-92b-3p	92.7449	NM_001128929
ROBO2	hsa-miR-6875-3p	92.4746	NM_001128929
ROBO2	hsa-miR-363-3p	92.2036	NM_001128929
ROBO2	hsa-miR-367-3p	92.2036	NM_001128929
ROBO2	hsa-miR-4731-3p	92.0396	NM_001128929
ROBO2	hsa-miR-4282	91.8279	NM_001128929
ROBO2	hsa-miR-636	91.6192	NM_001128929
ROBO2	hsa-miR-454-3p	91.3901	NM_001128929
ROBO2	hsa-miR-4659b-3p	91.2878	NM_001128929
ROBO2	hsa-miR-4659a-3p	91.2878	NM_001128929
ROBO2	hsa-miR-579-3p	91.2771	NM_001128929
ROBO2	hsa-miR-664b-3p	91.2771	NM_001128929
ROBO2	hsa-miR-5585-5p	91.2764	NM_001128929
ROBO2	hsa-miR-494-3p	91.2449	NM_001128929
ROBO2	hsa-miR-4287	91.165	NM_001128929
ROBO2	hsa-miR-4685-3p	91.165	NM_001128929
ROBO2	hsa-miR-3529-3p	90.8122	NM_001128929
ROBO2	hsa-miR-627-3p	90.6513	NM_001128929

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Motifs and transcription factors (TFs) regulating ROBO2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ROBO2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ROBO2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ROBO2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ROBO2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ROBO2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ROBO2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ROBO2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ROBO2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ROBO2	metacluster_3.14	WT1; WT1 (directAnnotation).
ROBO2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ROBO2	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."