Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNGTT

Summary for RNGTT

Gene information	Gene symbol	RNGTT
	Ensembl ID	ENSG00000111880
	Entrez ID	8732
	Gene name	RNA guanylyltransferase and 5'-phosphatase
	Synonyms	hCAP\|HCE\|HCE1
	Gene type	protein_coding
	UniProtAcc	O60942

Top

Dataset with differentially expressed gene: RNGTT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.289245	6.02e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.303207	9.48e-04

Top

Expression of RNGTT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to RNGTT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating RNGTT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNGTT	hsa-miR-488-3p	98.6429	NM_001286426
RNGTT	hsa-miR-374a-3p	96.0327	NM_001286426
RNGTT	hsa-miR-4330	95.3975	NM_001286426
RNGTT	hsa-miR-216a-3p	93.6424	NM_001286426
RNGTT	hsa-miR-128-3p	93.6424	NM_001286426
RNGTT	hsa-miR-10527-5p	93.3344	NM_001286426
RNGTT	hsa-miR-586	92.9537	NM_001286426
RNGTT	hsa-miR-6507-5p	92.1038	NM_001286426
RNGTT	hsa-miR-513b-5p	91.9038	NM_001286426
RNGTT	hsa-miR-4799-5p	91.1885	NM_001286426
RNGTT	hsa-miR-548x-3p	91.0922	NM_001286426
RNGTT	hsa-miR-548aj-3p	91.0922	NM_001286426
RNGTT	hsa-miR-194-5p	91.0864	NM_001286426
RNGTT	hsa-miR-3681-3p	91.0173	NM_001286426
RNGTT	hsa-miR-3942-3p	90.8354	NM_001286426
RNGTT	hsa-miR-548e-5p	90.1411	NM_001286426
RNGTT	hsa-miR-936	90.0026	NM_001286426
RNGTT	hsa-miR-3191-5p	89.8905	NM_001286426
RNGTT	hsa-miR-5692a	89.7663	NM_001286426
RNGTT	hsa-miR-4303	89.3918	NM_001286426
RNGTT	hsa-miR-27b-3p	89.3429	NM_001286426
RNGTT	hsa-miR-9985	89.3429	NM_001286426
RNGTT	hsa-miR-27a-3p	89.3429	NM_001286426
RNGTT	hsa-miR-548j-3p	89.2784	NM_001286426
RNGTT	hsa-miR-548ah-3p	89.2784	NM_001286426
RNGTT	hsa-miR-548am-3p	89.2784	NM_001286426
RNGTT	hsa-miR-548aq-3p	89.2784	NM_001286426
RNGTT	hsa-miR-548ae-3p	89.2784	NM_001286426
RNGTT	hsa-miR-205-3p	89.0916	NM_001286426
RNGTT	hsa-miR-451b	88.921	NM_001286426
RNGTT	hsa-miR-8077	88.516	NM_001286426
RNGTT	hsa-miR-137-3p	88.2593	NM_001286426
RNGTT	hsa-miR-3116	88.036	NM_001286426
RNGTT	hsa-miR-1290	86.797	NM_001286426
RNGTT	hsa-miR-3662	86.2142	NM_001286426
RNGTT	hsa-miR-4764-3p	86.0166	NM_001286426
RNGTT	hsa-miR-509-3-5p	85.8757	NM_001286426
RNGTT	hsa-miR-509-5p	85.8757	NM_001286426
RNGTT	hsa-miR-153-3p	84.8862	NM_001286426
RNGTT	hsa-miR-222-5p	84.2575	NM_001286426
RNGTT	hsa-miR-642a-3p	83.6763	NM_001286426
RNGTT	hsa-miR-642b-3p	83.6763	NM_001286426
RNGTT	hsa-miR-7111-3p	83.1387	NM_001286426
RNGTT	hsa-miR-4418	82.8352	NM_001286426
RNGTT	hsa-miR-651-3p	82.6577	NM_001286426
RNGTT	hsa-miR-888-5p	82.4179	NM_001286426
RNGTT	hsa-miR-448	82.0418	NM_001286426
RNGTT	hsa-miR-32-3p	81.764	NM_001286426
RNGTT	hsa-miR-4489	80.8389	NM_001286426

Page: 1

Top

Motifs and transcription factors (TFs) regulating RNGTT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNGTT	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RNGTT	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
RNGTT	transfac_pro__M06615	ZNF597 (directAnnotation).
RNGTT	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."